Linus Butt

Projekt-Manager für ein großes klinisches Studienprojekt (im Bereich Nephrologie) gesucht, multizentrische IIT (AMG). Lust in einem engagierten Studienteam mitzuarbeiten? Eine internationale Studie zu koordinieren? Dann sehr gerne direkt bei mir melden.

One of the most pressing questions in the era of caplacizumab is if iTTP can be managed without plasma exchange! Check out our paper addressing this question: Management of Immune Thrombotic Thrombocytopenic Purpura without Therapeutic Plasma Exchange ashpublications.org/blood/article-…

We perform a fully unsupervised analysis of the filtration barrier in kidney and show that it allows to group images in a way that reflects their morphometry: frontiersin.org/articles/10.33… Great collaboration with the NephroLab @unnersjo @LinusButt !

We have a freshly funded consortium in eye medicine in Cologne with plenty of challenging image analysis tasks ahead. We're looking for a postdoc, please spread/apply! euraxess.ec.europa.eu/jobs/183995

Advanced optical imaging reveals preferred spatial orientation of #podocyte processes along the axis of glomerular capillaries. doi.org/10.1016/j.kint… #glomerulus #ultrafiltration

Deep learning–based segmentation and quantification of #podocyte foot process morphology suggests differential patterns of foot process effacement across #kidney pathologies doi.org/10.1016/j.kint… #ArtificialIntelligence #pathology @KTHuniversity @UniCologne

Our study on deep learning-based segmentation and multi-parameter morphology analysis of foot processes is online! Thanks for a great collaboration @LinusButt @bozeklab @HoehneMartin @BernhardScherm1 kidney-international.org/article/S0085-…

New preprint out. Using 3D high-resolution imaging, we found that the orientation of podocyte processes is likely governed by the mechanical forces acting on them. Thanks to all co-authors! @amer_rc @LinusButt @HoehneMartin @BernhardScherm1 biorxiv.org/content/10.110…

Caloric restriction protects from #kidney injury in rodents. But translation to humans requires unravelling the molecular mechanisms. A spotlight on NAD de novo biosynthesis and acetylation of metabolic enzymes. @UniCologne @CECAD_ @UKKoeln see 🧵below journals.lww.com/jasn/Abstract/…

Our meeting report on the 13th International Podocyte Conference 2021 is out. Thanks to the fabulous Rachel Lennon @RLWczyk and her team and all other authors. @syb_k @fab_braun @LinusButt @F_Lausecker @MarylineFresqu1 pubmed.ncbi.nlm.nih.gov/35964799/

Finally heading for our nephrolab retreat! 🏝🏝🏝

19) Thank you for coming back! You are learning from @hjanders_hans all about #CKD + #T2D while you earn 🆓CE/#CME! Hello to @kdjhaveri @KuppeChristoph @Tiff_Caza @AstridWeins @suz_allison @LinusButt @Renalpathsoc @JeanHouMD @ChristophWanne4 @mvaduganathan @KidneyPath

Which longevity-associated dietary intervention protects best from ischemia-reperfusion injury? Check out Felix Koehler's recent work bit.ly/35l38Sq to find the answer and some insights into a convergent metabolic response. #diet #kidney #longevity

Mice carrying a common mutation in the gene encoding podicin show signs of podocyte injury as they age and after injection with a nephrotoxin—suggesting that the mutation confers a genetic predisposition to glomerular disease bit.ly/j202006085 @HoehneMartin

📣 🆕 𝗜𝗦𝗡 𝗩𝗜𝗗𝗘𝗢 𝗔𝗕𝗦𝗧𝗥𝗔𝗖𝗧 𝗦𝗘𝗥𝗜𝗘𝗦: A mathematical estimation of the physical forces driving podocyte detachment. 2021 from @kidney_Int kidney-international.org/article/S0085-… @LinusButt @unnersjo @HoehneMartin @BernhardScherm1

Great to see our recent review on the current knowledge of #RNA-binding proteins in #kidney disease and potential therapeutic implications published online by @NatRevNeph. Wonderful work, @SisaLeufert and the great team @CECAD_ @UniCologne @UKKoeln nature.com/articles/s4158…

New preprint for all you paraffin embedding-lovers out there, with @amer_rc @LinusButt @HoehneMartin @BernhardScherm1 and others.

A fantastic start to #podocyte2021 - the pre-meeting organised the amazing early career team ⁦@F_Lausecker⁩ ⁦@RW_Naylor⁩ ⁦@MarylineFresqu1⁩ ⁦@PinyuanTian⁩ ⁦@syb_k⁩ & ⁦@LinusButt⁩ - congrats! You have set the bar high!! ⁦@podocyte2021⁩

The glomerular filtration barrier: a structural target for novel kidney therapies go.nature.com/36Eh6fH - find out about the potential for a new generation of drugs for kidney diseases in this new review by @ilse_daehn @ISMMSKidney @DOMSinaiNYC and Jeremy Duffield @DuffieldLab

Check out AMAP, our fully automated algorithm for segmentation and quantification of foot process morphology. Great collaborative effort with ⁦@unnersjo⁩ ⁦@bozeklab⁩ ⁦@HoehneMartin⁩ ⁦@BernhardScherm1⁩ and more biorxiv.org/content/10.110…