MariaLafaille Lab

Extreme budget cuts for science in Argentina can put in peril generations of scientists. nature.com/articles/d4158…

Congratulations Hernandez!

@hernandezmsilva Congratulations Hernandez!

Dear Dusan and Dusanites colleagues: we will miss you big time!!! Best wishes as you move to the other side of town. @BogunovicLab

It’s been 10y since we opened our lab at @IcahnMountSinai. What an exciting ride and supportive environment it has been. We are now moving to @Columbia @ColumbiaPeds. Thrilled at the future and discoveries in genetics and immunology to come.

New work from the Victora lab (@victora_lab) explains why in secondary immunizations, new germinal centers form from naïve cells that bind poorly to the antigen. It’s all about pre-existing antibodies! nature.com/articles/s4157… biorxiv.org/content/10.110…

Results of the first stage of the NIAID funded CoFAR OUtMATCH trial, involving 10 sites including Mount Sinai (Scott Sicherer, PI) were just reported nejm.org/doi/pdf/10.105…

Important news for pediatric food allergy!! The FDA approved anti-IgE (Omalizumab) treatment to reduce reactions to accidental exposures to allergenic foods. More in nih.gov/news-events/ne….

Original Article: Omalizumab for the Treatment of Multiple Food Allergies nej.md/4bLW7aS Editorial: Options for Multiple Food Allergies — Food Avoidance or Pharmacologic Treatment? nej.md/3IaTeD7

Terrific editorial work at @ScienceTM. A great journal to send your work to!

Super cool cover for the @ScienceTM Feb 7 24 issue by Claud Spadafora and Joshua Koenig.

@ScienceTM Super cool cover for the @ScienceTM Feb 7 24 issue by Claud Spadafora and Joshua Koenig.

This week's new issue of #ScienceTranslationalMedicine has arrived! Researchers uncover stealthy immune saboteurs that drive allergic memory in humans, a new analysis in mice reveals how the brain recovers after stroke, and more. scim.ag/5N7

Therefore, the findings described in our new @ScienceTM manuscript link these Type 2 IgG memory B cells to the production of peanut allergy-causing IgE antibodies, an important discovery for understanding and treating #FoodAllergy. 5/n

When we isolated the cells that directly bind the main peanut allergen Ara h 2, we found that they belong to the Type 2 IgG memory cells, they contain clones that are similar between different individuals, and they produce antibodies that bind Ara h 2 with high affinity. 4/n

Check out our paper in @ScienceTM with insight into how B cell memory for allergen-specific IgE antibodies is stored in CD23+IgG1+ memory B cells in kids with peanut allergies. Similar findings in pollen allergy reported in the same issue by @jfekoenig 1/n science.org/doi/10.1126/sc…

B cells rule

Our new manuscript on by Miyo Ota, Ken Hoehn and collaborators reveals the importance of type2-marked IgG memory cells in food allergy persistence. @SinaiImmunol @hoehnousk @skeinstein biorxiv.org/content/10.110…