Maier Lab

Congratulations to Yuping Li for being awarded a prestigious #SNSFStartingGrant to study the interaction between bacteria and jumbo phages. Looking forward to great science! @biozentrum @NCCR_AntiResist @Unibasel_en @snsf_ch biozentrum.unibas.ch/news/detail/sn…

The first of a series of new #SerialEM tutorial videos is online - Autocontouring of Grid Squares. Let us know what you think and what topics you would like to see covered in the future! vimeo.com/1009837716

Congrats to our new SNSF #Ambizione Fellows, Janani Durairaj and Fengjie Wu! @janani_hex will explore variations in viral proteomes & virus evolution. Wu will investigate the dynamics of an important family of cell receptors #GPCR. @UniBasel_en @snsf_ch biozentrum.unibas.ch/news/detail/tw…

Thrilled to announce that Prof. Michael N. Hall @biozentrum @UniBasel_en has been awarded the 2024 @BalzanPrize for Biological Mechanisms of Ageing. Congratulations to Michael Hall and the three other prize winners! biozentrum.unibas.ch/news/detail/ba…

Beautiful!

How can memories persist in the brain when their properties and supporting biological substrates change over time and experiences? Our latest work newly published in @ScienceMagazine proposes that a balance between memory dynamics and persistence is achieved through the divergent recruitment of multiple memory traces established in parallel upon memory encoding. science.org/doi/10.1126/sc… Welcome to the Multiverse of Memory! A thread. 1/7

@moritzhunkeler Welcome back to Switzerland !

Goodbye Boston 👋🥲

Our c-di-GMP sensor story is finally out in @NatureComms: rdcu.be/dHsEh. Including new data demonstrating cdGreen2 as a convenient tool to study DGC and PDE activity in vitro. Great collaboration with @simon_vanvliet and @MaierLab!

Join our great BioEM lab team to shape how we use state-of-the-art electron microscopy equipment to study macromolecular assemblies and cell architecture.

Nature research paper: mRNA reading frame maintenance during eukaryotic ribosome translocation go.nature.com/3N4WX7X

Excited to share our in situ #CryoET story on the effect of a top antimalarial drug candidate on the translational landscape in #CryoFIB-milled malaria parasites! So proud of this massive team effort with @leonie_anton @_wenjing_cheng_ @mehsehret @davwcbb🥰#officially #teamtomo

@mimi1inh @leonie_anton @mehsehret @davwcbb Impressive tour de force to analyze the impact of treatment conditions on translation in the malaria parasite with a multi-method approach from omics to cryo-ET - Congrats to everyone involved.

How do only 2 non-visual arrestin isoforms regulate ~800 GPCRs? Our research on CCR5 phosphorylation uncovered a key pXpp phosphomotif crucial for robust arrestin2 recruitment, illuminating intricate details of GPCR desensitization. Now in @MolecularCell doi.org/10.1016/j.molc…

A team effort with @petrovic_iv and outstanding collaboration with @MaierLab and @arshukla

This was a spectacular collaboration with @BJ_Greber, and @simakali1. Initially, we thought we would need months of microscope time. @AdrianKoh8 & @cushing_v got all data and first structures within 2 weeks! To make this happen we designed a fast #SBDD workflow with @AdrianKoh8👇

Interesting to see myself age so much in one click of a slide 😅. Thanks a lot @ribo_rob for dropping by the @biozentrum to share your beautiful mitoribosome research and to tell us about your new company @cryocloud_io. Providing cloud processing for #CryoEM & #TeamTomo!❄️🔬☁️💻

Here we defined the interactions between the novel enzymatic components responsible for the so far unparalleled introduction of a vinyl chloride moiety to a 21-carbon chain during polyketide elongation! Congrats to the team: @MraDll, Max, Roy, Cedric, Groll lab, and @piel_lab!

Congratulations to @Yves80289860 for completing his PhD in our lab @biozentrum 🥳🥳. Yves’ research provided a big leap forward in understanding the architecture of giant biosynthetic assembly lines known as modular polyketide synthases 👉bit.ly/3Lelpnp. 🎉

@Grininger_Lab Great review, @Grininger_Lab put a lot of dedication and effort into providing a comprehensive overview on the structural biology of modular polyketide synthases. Must-read for anyone interested in this fascinating family of biosynthetic assembly lines.

Congrats Polina, and all the best for your future research @psich_en.