Huge congrats to @JulieSmeyers for being awarded a Springboard Fellowship from Target ALS!
targetals.org/2025/12/08/spr…
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Mordes Lab
56 posts
Mordes Lab
@MordesLab
Integrating neuropathology, stem cells, and multi-omics to study neurodegeneration #ALS #dementia @UCSFPath @INDUCSF 🧠🔬🌻
San Francisco, CA Bergabung Şubat 2022
143 Mengikuti145 Pengikut
Excited to share our @CellReports article! We investigated how the loss of TBK1 function contributes to ALS and dementia using human stem cell-derived neurons and advanced proteomics. Many thanks to all co-authors for their great work and collaboration!
sciencedirect.com/science/articl…
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Regulation of translation elongation and integrated stress response in heat-shocked neurons: Cell Reports cell.com/cell-reports/f…
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Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing: nature.com/articles/s4146…
Philadelphia, PA 🇺🇸 English
In this study, we observed that a C9ORF72-ALS/FTD dipeptide repeat protein perturbs the phosphorylation of RNA binding proteins and STMN2 expression, and found that SRSF7 sustains STMN2 levels in induced neurons. Congrats to @JulieSmeyers and Karen! #ALS
actaneurocomms.biomedcentral.com/articles/10.11…
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Excited to share new study from the lab, work led by @JohnPAndrews_MD and grateful for all the collaborators who made this possible including @ChangLabUcsf @ucscgenomics
UCSF Neurosurgery@NeurosurgUCSF
Today in @NatureNeuro, researchers led by @LabNowakowski, @ChangLabUCSF & Mircea Teodorescu (@ucscgenomics) demonstrate the first use of optogenetics to modulate seizure activity at the network level in human brain tissue: nature.com/articles/s4159… @JohnPAndrews_MD @UCSFstemcell
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Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes
cell.com/neuron/fulltex…
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Had a great time at the Oktoberfest IND collaboration hour! Thanks to everyone who stopped by.
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Out @ScienceMagazine! New tech to activate ALS gene therapies only in the right cells at the right time - Increased safety to have more options for ALS.
We do it by taking advantage of cryptic splicing.
science.org/doi/10.1126/sc…
@UCLIoN @TheCrick @OscarWilkins16 @MaxZYJChien
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Had a lot of fun at lab lunch! Welcome to the lab, Nicole and Lisa!
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Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing medrxiv.org/content/10.110…
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The Target ALS #DataEngine just got bigger!
We’ve expanded datasets across all core collections, added a user manual, and released new demo videos. Now it’s easier than ever to explore and utilize rich data for #ALSResearch.
Explore the updates: bit.ly/3yVk2GF
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Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions: Neuron cell.com/neuron/fulltex…
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Excited to finally share work from a past life! In this small study we dissect neuronal vulnerability, myelin dysfunction and microglia activation in #ALS read our full work on @NatureAging
nature.com/articles/s4358…
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Check out the data that goes along with our new manuscript & conduct an exciting secondary analysis of your own! @RCFNeuro @alzdemjournals
Alzheimer's Disease Data Initiative@AlzData
New data from the @YokoyamaLabUCSF and @UCSFmac is now available on AD Workbench. Researchers can use this dataset to identify novel disease associations, cell-specific impacts, and therapeutic targets for Alzheimer’s. Access data via AD Workbench: bit.ly/45C3zmA
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Excited to share this review on one of my favorite biological problems:
Selective vulnerability in neurodegenerative disease, and how recent technologies are yielding new insights into the underlying mechanisms.
Out in @NatRevNeurosci today!
nature.com/articles/s4158…
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Exciting study from the Gitler Lab: TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes biorxiv.org/content/10.110…
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Really excited about our latest preprint, where we uncovered a neuroprotective role for neuronal polyunsaturated fatty acids in FTD and ALS. Led by @AshlingGiblin and @AlexCammack biorxiv.org/cgi/content/sh… 1/9
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Are you an incoming UCSF grad student interested in doing research in neurodegeneration? If you are, join us at the IND OPEN HOUSE @ Helen Diller on 11/15 to meet our current trainees and faculty and to discuss their research!
Register here: forms.gle/sqTX5GLNoHiGym…
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