Greg Findlay

281 posts

Greg Findlay

@TheGenomeLab

Group Leader of the Genome Function Laboratory @TheCrick From 2025, find me over on the other side: https://t.co/ajOqpCvaUY (he/him)

London Bergabung Temmuz 2011

298 Mengikuti1.2K Pengikut

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Greg Findlay@TheGenomeLab·24 Mar

Great to see this out now in @CellGenomics . A few points about what we learned in revisions over on BlueSky: bsky.app/profile/gregfi…

Greg Findlay@TheGenomeLab

Our latest from @TheCrick, now on @biorxivpreprint: biorxiv.org/content/10.110… Michael Herger (@HergerMichael) and Christina Kajba jointly led development of a new prime editing platform for testing large numbers of human genetic variants.

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Greg Findlay@TheGenomeLab·30 Eyl

@AkramulSourav Dear Akramul, Yes - Crick PhD positions are open to international students! Out of fairness, I don't discuss project opportunities with individual applicants until shortlisting, but please apply using the link above if interested. Best, Greg

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Akramul Hassan@AkramulSourav·27 Eyl

@TheGenomeLab Dear Dr. Greg Findlay, Is this open for international students? This research project perfectly aligns with my research interest. Can I get your email to talk about the possible opportunities? Thank you.

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Greg Findlay@TheGenomeLab·27 Eyl

Crick PhD recruitment for fall 2025 is officially open! Please apply to our lab through the Crick application portal if interested. 👇 crick.ac.uk/careers-study/…

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Greg Findlay me-retweet

David Balchin@balchin_david·27 Eyl

Join us for a PhD! Applications close November 5th. crick.ac.uk/careers-study/…

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David Balchin@balchin_david·13 Ağu

New from our lab @TheCrick , led by @BetkaRoe. A fun side project that tried to understand what happens when a chaperonin encounters a translating ribosome. biorxiv.org/content/10.110…

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Colleen Drapek@ColleenDrapek·15 Tem

Come join us in making agriculture sustainable at @PhytoformLabs! 🌱We are looking for an R&D scientist with a background in Synthetic biology to join our tools & traits team for precision genome editing 🧬. If you think this could be you, please apply! linkedin.com/jobs/view/3972…

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Nicky Whiffin@nickywhiffin·11 Tem

So excited that our paper “De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome” is out today in @Nature nature.com/articles/s4158… 🧵 1/16

Yuyang Chen@quenchentin

(1/4) I’m delighted to announce that our research on RNU4-2 is now out on @Nature . This is an exciting finding that will bring many diagnoses worldwide. We have updated some new results since the preprint: nature.com/articles/s4158…

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The Francis Crick Institute@TheCrick·9 Tem

We are delighted to announce that Professor Edith Heard has been appointed as our new director and chief executive! Edith, who is currently director-general at @EMBL, will succeed Paul Nurse in leading the Crick from the summer of 2025. 🔗 crick.ac.uk/news/2024-07-0…

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Chloé Terwagne@ChloeTerwagne·5 Tem

Want to fully investigate this large dataset beyond classical 2D formats? Go interactively explore the data 👇 vhl-board.onrender.com

Greg Findlay@TheGenomeLab

The VHL data can also be searched, visualised, and explored using this awesome SGE visualisation platform made by @ChloeTerwagne: vhl-board.onrender.com Chloé’s code is all on GitHub if you’re interested in viewing and sharing your own data like this. (3/n)

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Greg Findlay@TheGenomeLab·5 Tem

@JohnDoench @megan_buckley01 @NatureGenet Yes, the van ride! So critical... ;) Thanks, John!

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Greg Findlay@TheGenomeLab·5 Tem

Our work led by @megan_buckley01 on Saturation Genome Editing of VHL is now out in @NatureGenet: nature.com/articles/s4158… Many new experiments and analyses to quickly highlight… (1/n)

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Greg Findlay@TheGenomeLab·5 Tem

@SaraGutierrezEn @megan_buckley01 @NatureGenet Thanks, Sara!

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Sara Gutiérrez-Enríquez@SaraGutierrezEn·5 Tem

@TheGenomeLab @megan_buckley01 @NatureGenet WOW, Greg! What a piece of incredibly useful data for variant classification. This will greatly benefit VHL cancer-related patients, providing better and personalized clinical management for their tumors👏🏽👏🏽

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Greg Findlay@TheGenomeLab·5 Tem

Finally, we’re delighted to see this published back-to-back with a massive SGE analysis of BAP1 led by Andrew Waters, @David_J_Adams and co. @sangerinstitute: nature.com/articles/s4158… So many more variants now readily interpretable, and still more on the way! (9/9)

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Greg Findlay@TheGenomeLab·5 Tem

Of course, we hope you read the paper and use the data. Do feel free to reach out with questions on anything from protocol tips to variant classifications. (8/n)

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Greg Findlay@TheGenomeLab·5 Tem

Massive thanks to all authors, but particularly @ChloeTerwagne, Athina Ganner, @LauraCubitt3, @ReidBrewer3, Dong-Kyu Kim & @Eivakine for key inputs to revisions. And, of course, many thanks to reviewers, @nature_genet, and funders @TheCrick @CRUKresearch (7/n)

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Greg Findlay@TheGenomeLab·5 Tem

Lots more new analyses and validations in the paper, too. For instance, comparing function scores to SpiceAI and FoldX computational predictions – both of which do reasonably well. (6/n)

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Greg Findlay@TheGenomeLab·5 Tem

In new experiments, we also characterise novel mechanisms made apparent by SGE. Specifically, we show that a long C-terminus extension leads to LoF via VHL protein destablization and that stop-codon readthrough can impact the degree of functional impairment. See Fig. 6! (5/n)

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Greg Findlay@TheGenomeLab·5 Tem

Importantly, we now split loss-of-function variants by SGE score into LOF1 (lowest) and LOF2 (depleted, weaker effect). In collaboration w Athina Ganner and Freiburg colleagues, we show how patients with VHL disease can be stratified by ccRCC risk using these categories. (4/n)

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Greg Findlay@TheGenomeLab·5 Tem

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Greg Findlay@TheGenomeLab·5 Tem

Most importantly, all SGE scores and variant classifications are available for download in Supplementary Table 1 and from MAVEdb (mavedb.org/experiments/ur…). Given the data’s high precision, we expect this will lead to a steep reduction in VUS reported clinically. (2/n)

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Jelajahi

@AkramulSourav @TheCrick @BetkaRoe @PhytoformLabs @Nature @embl @megan_buckley01 @NatureGenet