Greg Findlay

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Greg Findlay

Greg Findlay

@TheGenomeLab

Group Leader of the Genome Function Laboratory @TheCrick From 2025, find me over on the other side: https://t.co/ajOqpCvaUY (he/him)

London Katılım Temmuz 2011
298 Takip Edilen1.2K Takipçiler
Greg Findlay
Greg Findlay@TheGenomeLab·
@AkramulSourav Dear Akramul, Yes - Crick PhD positions are open to international students! Out of fairness, I don't discuss project opportunities with individual applicants until shortlisting, but please apply using the link above if interested. Best, Greg
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Akramul Hassan
Akramul Hassan@AkramulSourav·
@TheGenomeLab Dear Dr. Greg Findlay, Is this open for international students? This research project perfectly aligns with my research interest. Can I get your email to talk about the possible opportunities? Thank you.
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Greg Findlay
Greg Findlay@TheGenomeLab·
Crick PhD recruitment for fall 2025 is officially open! Please apply to our lab through the Crick application portal if interested. 👇 crick.ac.uk/careers-study/…
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Colleen Drapek
Colleen Drapek@ColleenDrapek·
Come join us in making agriculture sustainable at @PhytoformLabs! 🌱We are looking for an R&D scientist with a background in Synthetic biology to join our tools & traits team for precision genome editing 🧬. If you think this could be you, please apply! linkedin.com/jobs/view/3972…
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Nicky Whiffin
Nicky Whiffin@nickywhiffin·
So excited that our paper “De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome” is out today in @Nature nature.com/articles/s4158… 🧵 1/16
Yuyang Chen@quenchentin

(1/4) I’m delighted to announce that our research on RNU4-2 is now out on @Nature . This is an exciting finding that will bring many diagnoses worldwide. We have updated some new results since the preprint: nature.com/articles/s4158…

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The Francis Crick Institute
The Francis Crick Institute@TheCrick·
We are delighted to announce that Professor Edith Heard has been appointed as our new director and chief executive! Edith, who is currently director-general at @EMBL, will succeed Paul Nurse in leading the Crick from the summer of 2025. 🔗 crick.ac.uk/news/2024-07-0…
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Chloé Terwagne
Chloé Terwagne@ChloeTerwagne·
Want to fully investigate this large dataset beyond classical 2D formats? Go interactively explore the data 👇 vhl-board.onrender.com
Greg Findlay@TheGenomeLab

The VHL data can also be searched, visualised, and explored using this awesome SGE visualisation platform made by @ChloeTerwagne: vhl-board.onrender.com Chloé’s code is all on GitHub if you’re interested in viewing and sharing your own data like this. (3/n)

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Greg Findlay
Greg Findlay@TheGenomeLab·
Of course, we hope you read the paper and use the data. Do feel free to reach out with questions on anything from protocol tips to variant classifications. (8/n)
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Greg Findlay
Greg Findlay@TheGenomeLab·
Lots more new analyses and validations in the paper, too. For instance, comparing function scores to SpiceAI and FoldX computational predictions – both of which do reasonably well. (6/n)
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Greg Findlay
Greg Findlay@TheGenomeLab·
In new experiments, we also characterise novel mechanisms made apparent by SGE. Specifically, we show that a long C-terminus extension leads to LoF via VHL protein destablization and that stop-codon readthrough can impact the degree of functional impairment. See Fig. 6! (5/n)
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Greg Findlay
Greg Findlay@TheGenomeLab·
Importantly, we now split loss-of-function variants by SGE score into LOF1 (lowest) and LOF2 (depleted, weaker effect). In collaboration w Athina Ganner and Freiburg colleagues, we show how patients with VHL disease can be stratified by ccRCC risk using these categories. (4/n)
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Greg Findlay
Greg Findlay@TheGenomeLab·
The VHL data can also be searched, visualised, and explored using this awesome SGE visualisation platform made by @ChloeTerwagne: vhl-board.onrender.com Chloé’s code is all on GitHub if you’re interested in viewing and sharing your own data like this. (3/n)
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Greg Findlay
Greg Findlay@TheGenomeLab·
Most importantly, all SGE scores and variant classifications are available for download in Supplementary Table 1 and from MAVEdb (mavedb.org/experiments/ur…). Given the data’s high precision, we expect this will lead to a steep reduction in VUS reported clinically. (2/n)
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Keşfet

@AkramulSourav @TheCrick @BetkaRoe @PhytoformLabs @Nature @embl @megan_buckley01 @NatureGenet