Ryan Smith

Join us! We're hiring a Research Scientist to support projects on mosquito immunity and mosquito‑borne disease transmission. Ideal for a post‑bac or recent M.S. looking to gain experience in cutting-edge research in vector biology. isu.wd1.myworkdayjobs.com/IowaStateJobs/…

👀There will be a Keystone Symposium with a focus on Vector-Pathogen Interactions to be held in Geneva, Switzerland in February 2027. It should be a great meeting and hope to see you there! keystonesymposia.org/conferences/co…

Make sure you keep this in mind and start early if you are going to be submitting to the February NIH deadlines!

As a heads up, it is now required that your NIH biosketch be created using Sciencv. This can be tricky since ORCID must be linked to your MyNCBI account, and for many, including myself, multiple accounts may have to be merged by NIH support staff. grants.nih.gov/grants/guide/n…

I'd like to thank the colossal efforts of @samantsidis and Hyeogsun Kwon, as well as the help from the UMITF in providing transgenic An. gambiae.

Our latest work developing genetic markers for mosquito hemocytes and their characterization using spectral imaging flow cytometry. The result is an advanced characterization of mosquito immune cells and the foundation for building genetic tools. nature.com/articles/s41...

I'd also like to acknowledge the huge contributions from @EnzoMameli and @samantsidis in this monumental and collaborative study

Pleased to share our recent work in collaboration with the @PerrimonLab in which we perform the first genome-wide CRISPR knockout screen in Anopheles to examine essential fitness genes and genes associated with clodronate liposome function rdcu.be/eRxmT

🦟 We've just published the world's first head-to-toe single-cell atlas of the Aedes aegypti mosquito in @CellCellPress! The #MosquitoCellAtlas maps 69 cell types across 19 tissues, revealing surprising biology: mosquitoes taste with their legs (more than we thought), glial cells (not neurons!) dramatically rewire after blood meal & males/females are nearly identical at the cellular level—with intriguing exceptions. Read it here: cell.com/cell/fulltext/…

@AdegokeDVM_PhD @NIH Who are you working with?

Just concluded my first week as a postdoc at @NIH in the Laboratory of Malaria and Vector Research (LMVR). Excited to advance research on vector–host–pathogen interactions. Grateful for the journey so far and thankful to mentors and colleagues for their support.

@VandyBugs @VanderbiltU @IowaStateU Thanks again Julian! I had a great time and it was nice to catch up!

Biological Sciences seminar series ⁦@VanderbiltU⁩ kicked off for the year with Dr. Ryan Smith ⁦⁦@Vectorimmunlab⁩ from ⁦@IowaStateU⁩ presenting on his new discoveries on mosquito hemocytes. Great talk!

Drs David Hall & @Vectorimmunlab highlight @merkling_lab & colleagues’ @CellGenomics article on #mosquito cellular responses in #midgut & #fatbody after #bloodfeeding. #Aedes #aegypti #scRNAseq #Metabolomics @IowaStateU @institutpasteur @univ_paris_cite authors.elsevier.com/a/1lbEr5Eb1xN6…

Celebrating the holiday weekend with another bang! Our work describing roles of TNF signaling on mosquito immune cell function and in limiting malaria parasite infection is now published. Big shout out to @samantsidis and others for their contributions! journals.plos.org/plospathogens/…

@TheBaiLab My understanding is that STING signaling isn’t present in mosquitoes, although there could be some other type of suppression. We have a lot of work to do still!

@Vectorimmunlab Could these virus find a specific way to escape the host immune surveillance in mosquito hemocyte, via a suppression of mosquito cGAS/STING signaling?

Excited to share our latest collaborative work with looking at the role of mosquito immune cells in virus infection. It turns out that these cells actually help disseminate an infection, increasing the potential for virus transmission rdcu.be/euiZt

I am thrilled to present the Mosquito Cell Atlas! We analyzed 367K nuclei from 19 tissues in male & female mosquitoes, creating a comprehensive resource for vector biology & infectious disease research. Plus we made some surprising discoveries! 🦟🧵 biorxiv.org/content/10.110… 1/n

BIG NEWS! The Mosquito Cell Atlas preprint is live! 🦟🧬 My first senior author paper! Massive and accessible snRNA-seq dataset and a lot of cool mosquito biology. A true collaborative achievement! #MCA biorxiv.org/content/10.110… See @oliwiagoldman thread ⬇️

@anyajoneal @JohnsHopkinsMMI @JohnsHopkinsSPH Wonderful news! Congrats!

With all the chaos going on, I’m excited to share a bit of good news: this September I will be starting as an Assistant Professor in the Lyme & Tickborne Diseases Research and Education Institute at @JohnsHopkinsMMI @JohnsHopkinsSPH! 🥹

I am super excited to share our latest review about the effects of blood-feeding and infection on arthropod (mosquitoes and ticks) hemocytes. Huge thanks to @theticklab and my mentor, @Vectorimmunlab, for their efforts in putting this together.. sciencedirect.com/science/articl…

🚨Interested in mosquito immunity and genetics? 🚨 We are recruiting for two post-doc positions: 1) Development of genetic tools to study mosquito immune cells isu.wd1.myworkdayjobs.com/IowaStateJobs/… 2) Role of mosquito immune cells in immune recognition and priming isu.wd1.myworkdayjobs.com/IowaStateJobs/…