Xyro

@rawsalerts Dead Internet Theory

🚨#BREAKING: According to Tech Sciencest they report that AI bot traffic is projected to surpass human internet traffic by 2027

Pancreatic cancer ranks among the most lethal cancers, with tumors often developing rapid resistance to therapies, contributing to dismal long-term outcomes. In a major preclinical advance, scientists at Spain’s National Cancer Research Centre (CNIO), led by Mariano Barbacid, have shown that a triple-drug combination can completely eliminate pancreatic tumors in mouse models while preventing resistance from emerging. The treatment targets the KRAS signaling pathway—mutated in about 90% of pancreatic ductal adenocarcinomas—at three separate points, effectively blocking the cancer's ability to adapt and survive. The regimen combines daraxonrasib (an experimental KRAS inhibitor, also known as RMC-6236), afatinib (an approved EGFR/HER2 inhibitor used in certain lung cancers), and SD36 (a selective STAT3 protein degrader). This multi-pronged attack shuts down key downstream, upstream, and parallel pathways that KRAS relies on for tumor growth and evasion of single-agent therapies. Tested across multiple orthotopic mouse models of pancreatic ductal adenocarcinoma (including those with KRAS/TP53 mutations), the combination induced complete and durable tumor regression, with no detectable cancer recurrence even months after treatment ended and no major toxicities observed. In some cases, tumors vanished entirely, leaving no trace. While single KRAS inhibitors show promise, resistance typically develops quickly as tumors activate bypass mechanisms. By hitting three independent nodes simultaneously, this strategy overcomes that hurdle in animals, offering a blueprint for more effective targeted therapies. Pancreatic cancer's five-year survival rate remains under 10%, underscoring the urgency of such innovations. Although human trials are not yet feasible and further optimization is needed to translate these results to patients, the study represents a landmark step toward making one of the deadliest cancers potentially controllable. [Liaki, V., Barrambana, S., Guerra, C., Barbacid, M., et al. (2025). A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance. Proceedings of the National Academy of Sciences, 122(49), e2523039122. DOI: 10.1073/pnas.2523039122]

@MyNintendoNews Water is wet

Nintendo Switch 2 handheld boost mode is great but it does impact battery life mynintendonews.com/2026/03/19/nin…

@Independent Cultists always support the cult leader. Not shocked at all

MAGA gives Trump 100% approval rating in new poll, leaving CNN analyst stunned independent.co.uk/news/world/ame…

@KirPinkFury Did you get your tickets already?

2 weeks until the Nintendo universe unfolds right before our very eyes.

@KirPinkFury It’s just faster downloading (in general) and helps with giving metrics to the devs.

I'll never understand pre-ordering a digital game.

@theblaze Water is wet

CNN: “The MAGA GOP view of Trump is 100%. Zero percent say that they disapprove. The MAGA base within the GOP is not shrinking.”

@Stealth40k No DuskBloods for 2026?

Nintendo released a new ad highlighting Switch 2's game lineup: - Fire Emblem Fortunes Weave - Donkey Kong Bananza - Pragmata - Resident Evil Requiem - FF VII Remake Intergrade - Monster Hunter Stories 3 - Elden Ring - Xenoblade Chronicles X + More

@DiscussingFilm Who?

First look at Trammell Tillman in ‘SPIDER-MAN: BRAND NEW DAY’.

@MCU_Direct That’s good to know.

Sony has now confirmed that SPIDER-MAN: BRAND NEW DAY is set 4 years after the events of SPIDER-MAN: NO WAY HOME!

@DEADLINE Which Sony Xperia is that?

Here’s your first trailer for #SpiderManBrandNewDay, which launches in cinemas from July 31 and stars Tom Holland, Zendaya, Mark Ruffalo, Sadie Sink, John Bernthal and more See more details here: deadline.com/2026/03/spider… (Video: Sony, Marvel)

@PlayStation Which Sony Xperia is that?

A Brand New Day starts now. Watch the official trailer for #SpiderManBrandNewDay, exclusively in theatres July 31. Play Marvel’s Spider-Man 2, available now in the PlayStation Plus Game Catalog.

@Kotaku Everything about that trailer was awesome except for The Hand. So sick of them. Despite that, I’m going 100% day 1

Spider-Man: Brand New Day Trailer Shows Spidey's New Powers kotaku.com/spider-man-bra… kotaku.com/spider-man-bra…

@jordnjnes @MarvelStudios @SpiderManMovie Which Sony Xperia is that?

#SpiderManBrandNewDay SPIDEY'S BAAACK!!!

@Luiz_Fernando_J Which Sony Xperia is that?

It’s hereeee!!! 5 years after #SpiderMan: #NoWayHome shattered CBM records Post-Covid, #TomHolland & #Zendaya are back as #Sony drops long anticipated first teaser trailer of #SpiderManBrandNewDay. #BrandNewDay debuts on JUL 31, peak SUMMER!

@Sony @SpiderManMovie Which Sony Xperia is that?

A Brand New Day starts now. Watch the official trailer for #SpiderManBrandNewDay - exclusively in theatres July 31.

@Trialsoftribute @Bosslogic 100%

@Bosslogic Prison wallet

Real talk tho, and it's important Where did he put his phone?

@Bosslogic Which Sony Xperia is that?

@GameXplain It doesn’t connect to Pokemon home. Zero reason to play it.

Pokemon XD Gale of Darkness is out RIGHT NOW on Switch 2 NSO. WATCH: youtu.be/RXDl2LzRZ6I

@NinEverything No pokemon Home support. No need to play this game.

Pokemon XD: Gale of Darkness just released on Nintendo Switch 2 via Switch Online nintendoeverything.com/pokemon-xd-gal…