Constantine Tzouanas

Out today in @CellCellPress! We studied how environmental stresses like high-fat diets today can prime tumorigenesis months to years in the future (1/n)

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The new issue is out! 👉cell.com/cell/current On the cover, Tzouanas et al. show how environmental stressors like high-fat diets challenge the social contract unifying cellular citizens, pushing some cells to prioritize their own survival over collective community goals.

And link to the paper itself cell.com/cell/fulltext/…

Link to X-planation summary of the paper x.com/constantine_sc…

Incredible to see our work on @CellCellPress cover! Environmental stresses like high-fat diets➡️cellular communities whose past histories & present neighbors shape future disease progression & cancer outcomes (with Akira-inspired Easter eggs too!). Appreciation to @TeamSciStories

Now online! Hepatic adaptation to chronic metabolic stress primes tumorigenesis dlvr.it/TPynWf

@dpolychr2 @dpolychr2 our paper just was published today and MATCHA is on Github at github.com/ctzouanas/MATC… - hope it's useful in your work!

@dpolychr2 Thanks for the nice words! Not quite yet - had some ducks to get in a row over holidays + while waiting for reviews, but I’ll send you an email/DM once it is!

New preprint! In chronic stress, cells must balance their own survival with tissue-level roles. Prior work has emphasized stress-induced drivers of cell death, but what happens to surviving cells? How do they adapt, and how do their changes connect to long-term dysfunction? (1/n)

@Bomin_Ku @Bomin_Ku it's been a long time coming, but our paper is finally published and MATCHA is on Github at github.com/ctzouanas/MATC… - hope it's useful in your work!

@Bomin_Ku Appreciate the kind words, and will do!

That’s all for now, folks – see here for a link to the paper itself! (fin/n) cell.com/cell/fulltext/…

Much appreciation & acknowledgement to all involved - co-first authors @drjessicashay @LiverQuant and co-senior authors @WGoessling @ohyilmaz @shaleklab, and many more who enabled this work @MIT_IMES @broadinstitute @kochinstitute @ragoninstitute @harvardmed @BrighamWomens (13/n)

Out today in @CellCellPress! We studied how environmental stresses like high-fat diets today can prime tumorigenesis months to years in the future (1/n)