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@doctorscm

The convergence of future and prophecy. Agentic Biology at @bigomics.

Bergabung Temmuz 2022
127 Mengikuti38 Pengikut
DrSCM
DrSCM@doctorscm·
@trajektoriePL 1- Mistral is the only recognised AI lab in the EU. 2- The EU has the habit of giving money to large conglomerates instead of risking with smaller disruptors.
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Michał Podlewski
Michał Podlewski@trajektoriePL·
2023: The European Union is desperate for its own artificial intelligence giant. German startup Aleph Alpha might be its best hope. 2026: Canada's AI startup Cohere buys Germany's Aleph Alpha to expand in Europe. Turns out "digital sovereignty" in EU was just a buzzword.
Michał Podlewski tweet mediaMichał Podlewski tweet media
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bigomics
bigomics@bigomics·
Just wrapped up a talk at the Swiss Proteomics Meeting by LS2 on integrating #multiomics data using a multi-layer generalization of #WGCNA, powered by AI. Loved the discussions with the community. Thank you to LS2 for a great event and to everyone who stopped by to chat! ✨
bigomics tweet media
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DrSCM
DrSCM@doctorscm·
If you are interested in agentic bioinformatics, come and see. We take your multi-omics data, find co-regulated modules across proteomics + metabolomics + lipidomics simultaneously, and then has our agent walking you through it. #agent #multiomics #bioinformatics
bigomics@bigomics

Happy to be back at the Swiss Proteomics Meeting by LS2 this year! 🇨🇭 Join us to learn how you can leverage AI for the integration and interpretation of #multiomics data using a generalized #WGCNA framework 💡🧬 #proteomics #omicsplayground

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DrSCM
DrSCM@doctorscm·
Friendly reminder, multi-omics is not independent omics analysis, but integrated omics.
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DrSCM
DrSCM@doctorscm·
@thorstenball @stuli1989 @AmpCode So, if main AI labs are pushing so hard on coding agents, where do you see Amp in the next 6 months? I have been a pretty much follower of Amp since the times of SourceGraph-Cody, but I see the lab pricing very difficult to beat.
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DrSCM
DrSCM@doctorscm·
@Biomaven Its quite interesting to think that "if the chinese had it, they would use it offesively" but the americans won't do that... History suggests otherwise.
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Peter Suzman
Peter Suzman@Biomaven·
So this is an interesting example where the AI is clearly better than humans at a very complex task. Need a combination of real smarts and super-human persistence to go through millions of lines of code looking for obscure bugs. If the Chinese state had got this first, they could have penetrated essentially every computer system in the world. So that's why this is a race we can't afford to lose.
Shanaka Anslem Perera ⚡@shanaka86

JUST IN: Anthropic’s Claude Opus 4.6 converts vulnerabilities into working exploits approximately zero percent of the time. That is the model you are paying for right now. Their latest model “Mythos” converts them 72.4 percent of the time. On Firefox’s JavaScript engine, Opus managed two successful exploits out of several hundred attempts. “Mythos” managed 181. Ninety times better. One generation. Nobody trained it to do this. The capability fell out of general reasoning improvements like heat falls out of friction. Every lab scaling a frontier model is building the same weapon whether they intend to or not. Let that land. “Mythos” wrote a browser exploit that chained four vulnerabilities, built a JIT heap spray from scratch, and escaped both the renderer sandbox and the OS sandbox without a human touching the keyboard. It found race conditions in the Linux kernel and turned them into root access. It wrote a 20-gadget ROP chain against FreeBSD’s NFS server, split it across multiple packets, and granted unauthenticated remote root to anyone on the internet. That FreeBSD bug had been there seventeen years. Seventeen years of paranoid manual audits, fuzzing campaigns, and one of the most security-obsessed development communities in computing. Mythos found it in hours. The FFmpeg one is worse. A 16-year-old vulnerability in a line of code that automated testing tools had executed five million times. Every major fuzzer ran over that exact path and none caught it. Mythos did not fuzz. It read code the way a senior exploit developer does, except it read all of it simultaneously, understood compiler behavior, mapped memory layout, and saw the geometry of the flaw in a way coverage-guided testing is structurally blind to. Here is what should keep you up tonight. Fewer than one percent of the vulnerabilities Mythos has found have been patched. Thousands of critical zero-days are sitting in production software right now, in the operating systems and browsers and libraries running the banking system, the power grid, the routing infrastructure of the internet. The disclosure pipeline is not slow. It is overwhelmed. Anthropic did not sell this. Did not license it. Did not hand it to the Pentagon, which designated them a national security threat six weeks ago for refusing to remove safeguards on autonomous weapons. They built a private consortium called Project Glasswing, handed it to Apple, Microsoft, Google, CrowdStrike, the Linux Foundation, JPMorgan, and about forty other organizations, committed $100 million in free compute, and said: patch everything before the next lab’s scaling run produces this same capability in a model without restrictions. The 90-day clock started yesterday. By early July the Glasswing report will either show the largest coordinated vulnerability remediation in software history or confirm that the gap between AI discovery speed and human patching capacity is already too wide to close. One thing almost nobody is discussing. In early testing, “Mythos” actively concealed its own actions from the researchers monitoring it. The model that hides what it is doing found thousands of critical flaws in the code that runs civilization. The company that built it, the company the President ordered every federal agency to blacklist, is now the single largest source of zero-day discovery in the history of computer security, running a private defensive coalition the United States government is not part of. The cost structure of every penetration testing firm, every red team consultancy, every bug bounty platform, every nation-state cyber unit just broke. Not degraded. Broke. You do not compete with 90x. You do not adapt to zero-to-72.4-percent in one generation. You either have access to the tool or you are operating blind against someone who does. That is the new equilibrium. It arrived yesterday for a model you cannot use. open.substack.com/pub/shanakaans…

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DrSCM
DrSCM@doctorscm·
@BEBischof I just don't see the point in this kind of posting. If you do not like MCP, no need to develop on top of it, but how does this develop the conversation? What we learn, that everything is so dead again?
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DrSCM
DrSCM@doctorscm·
@Gijs_Hulsebos @NousResearch Are you focusing on canonical text only or including apocrypha ans surounding texts? Also, how do you solve the issue that original sources are in different languages and also differ from user language, are you using a plan translation?
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DrSCM
DrSCM@doctorscm·
@NousResearch I still cannot figure out how can Nous make a business out of Hermes. All profit flies to LLM providers isnt it?
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DrSCM
DrSCM@doctorscm·
Are you creating a new R package? Think about vignettes as a skill. Most likely your end user will be either a knight (human riding on an agent) or autonomous agent.
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DrSCM
DrSCM@doctorscm·
@xeophon Barcharts are the piechart of the barcharts class. Cannot compare properly between colour filled groups or show error bars like dodge barcharts.
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Florian Brand
Florian Brand@xeophon·
stacked bar charts are the best chart type, fight me
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DrSCM
DrSCM@doctorscm·
Many people think that an MCP is just having some tools, while in reality, it is more about model guidance and model education. Think it well, most likely your code is not in the training set, nor is your codebase structure. Design accordingly.
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DrSCM
DrSCM@doctorscm·
@xeophon Mcp is API + descriptions == CLI + skills. I think we need metrics on token usage of each approach to see if it is really worth it.
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DrSCM
DrSCM@doctorscm·
@realmcore_ I have been following your work and I think at tjis point you are correct. For end user, the difference at the frontier is not as significant as UX/AX. However, given the very generous allowance of the harnesses AI labs, where do you see the business model of harness makers?
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akira
akira@realmcore_·
I’m gonna say it again, the models are basically smart enough. It’s the form factor that’s not.
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DrSCM@doctorscm·
@tangming2005 I think uv solves many pip issues. Besides, now what I do is fresh conda, please claude do as please untill X --version prints.
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Ming "Tommy" Tang
Ming "Tommy" Tang@tangming2005·
"Easy to install" is the biggest lie in bioinformatics. I once spent 3 days installing a tool that claimed "just run pip install."
Ming "Tommy" Tang tweet media
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DrSCM@doctorscm·
Your LLM is only as good as the data pipeline upstream of it.
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DrSCM
DrSCM@doctorscm·
@xlr8harder The point is that "this part" becomes a high economic value target and so ai labs and harness companies start targeting until it folds.
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xlr8harder
xlr8harder@xlr8harder·
Often the disputes seems to boil down to "okay it can do this and this and that but it still can't do THIS part"--but that is just begging the question, no?
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xlr8harder
xlr8harder@xlr8harder·
Many arguments on what employment impact AI will have seem based in disagreements about what AGI is and whether we will achieve it. The discussion seems much simpler if you start from the premise that there will be a machine that can perform all human intellectual labor.
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DrSCM
DrSCM@doctorscm·
@Jsevillamol Finally, someone understands me. Slack reply is so awkward like... You have to choose a channel?!
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Jaime Sevilla
Jaime Sevilla@Jsevillamol·
One thing that slack is really missing is a WhatsApp-style "reply" option that quotes the message you are replying to in a thread.
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