I recently did a post on it. Yes they enhance GABA, GABA directly modulates dopamine. So if it speeds up GABA, generally you can expect emotional blunting and sexual dysfunction to follow.
I posted a lot of detail in this thread and in a follow up reply to nick. x.com/KevinRo9032145…
It hits most of the major factors regarding what the SSRI does.
SSRI Suppress Phasic Dopamine Bursts
- why you don't get excited, orgasm, enjoy music or a good laugh and alcohol looses it's kick.
A little science then I'll explain what it means and how the the SSRI screwed up your ability to feel.
When you swallow an unhappy pill (SSRI). You jack up the serotonin levels in the synaptic cleft. Studies often put this at 200% to 400% increase in serotonin levels.
This extra serotonin hits receptor 5-HT2C in the Ventral Tegmental Area (VTA) which is a small cluster of neurons located in the midbrain.
This area of the brain is main origin of dopamine neurons. This stuff gets complicated but think of it as the tree trunk. 1 of 2. The other is the Substantia Nigra pars compacta (SNc).
The VTA is the main hub where all the good stuff happens. When you enjoy music, a laugh, orgasm, it requires dopamine spikes to take place. These spikes in dopamine activity are dampened directly leading to sexual dysfunction. The other brain areas are mostly downstream from the (VTA/SNc).
Those pesky 5-HT2C receptors being overloaded on dopamine neurons puts a physical cap on the ability for dopamine to be released and communicate enjoyment. Sure but why doesn't alcohol work? Isn't Alcohol GABA-A? Your right.
GABA neurons also have 5-HT2C receptors and they are being stimulated by the SSRI also. This enhances GABA activity. Alcohol also enhances GABA activity.
Given GABA activity is already greatly enhanced by the SSRI, Alcohol looses it's effectiveness it's already maxed out and dopamine release is already capped by the SSRI. The pleasant alcohol effects simply can't take place. This can lead to over consumption of alcohol as it takes more than usual to have an effect.
There is a lot more detail as to what's happening, but I can't realistically put it all into a Twitter post. Know this SSRI activate 5-HT2C which suppresses dopamine and takes out the ability to enjoy life.
That's why you can't feel on a SSRI and drugs that produce pleasure loose their effectiveness!
@grok How many Americans take SSRIs in the United States?
Some studies suggest 35% of people taking SSRIs develop Akathisia, is that true? If so, how many Americans would be affected with Akathisia?
Listen, I'm bad at math, didn't look at all the studies to come to a complete conclusion because I'm still struggling with my health, but know some publications stTe roughly 30%+ people that take SSRIs will develop Akathisia.
If Gemini is right about this Akathisia data...
Then we Americans are indeed looking at a national emergency.
I'm going to ask Grok next in the comments below 👇.
I just got an email from my vet's office for an "important health alert" regarding leptospirosis. Recommending 2 initial doses of the vaccine and a booster every year after....NOPE! Not gonna happen.
@KevinRo90321458 From my research, SSRIs can inhibit dopamine, correct? (Like 5-HTP as a supplement can as well?) Hence, so many people report lack of energy and motivation, emotional blunting, apathy, sexual dysfunction, etc. after long-term use of SSRI’s?