Poltorak Lab

#WeekendRead! #NoTimeToDie! Welcome to a new form of cell death: #efferoptosis! Poltorak, Muendlein &co show @SciImmunology that during systemic inflammation TNF reprograms efferocytic macrophages to activate caspase-8 (not NLRP3!) pyrotosis & IL1b release science.org/doi/10.1126/sc…

Activation of macrophages engulfing neutrophils by TNF switches efferocytosis to caspase-8–mediated pyroptosis and IL-1β production @SciImmunology @LabPoltorak science.org/doi/10.1126/sc…

Scientists have found that tumor necrosis factor can switch macrophage #efferocytosis from immunologically silent to pro-inflammatory during #sepsis and systemic inflammation. @LabPoltorak Learn more in Science #Immunology: scim.ag/45Yvj6Y

Excited to have contributed to this paper!!! Read here how STING regulates microglia in aging. Congrats to @kate_sulka and the whole team!!! @CellReports sciencedirect.com/science/articl…

Have you seen our papers on T-cell Myd88 in HF and cancer (links in 🧵) and wondered what the mechanism at the TCR was? We now outline a novel molecular role for MyD88 acting downstream of the TCR and regulating activation / cell death, out in @J_Immunol academic.oup.com/jimmunol/advan…

Thank you to @LabPoltorak @ZoieMagri @PilarAlcaidePhD for making this study possible. Previous papers on T-Myd88 at @CircRes (ahajournals.org/doi/10.1161/CI…) and @AJPathology (sciencedirect.com/science/articl…)

After reporting a role for T cell MyD88 during cardiac adaptation to stress @CircRes & in melanoma @AJPathology, we now decipher a molecular mechanism👇. Thank U @J_Immunol @AbeBayer @LabPoltorak @ZoieMagri @TuftsMedSchool academic.oup.com/jimmunol/advan…

#EveryCellIsAnImmuneCell!💥Thrilled💥for our new paper @CellCellPress with @achillebro! We show that, during #IBD, type III #interferons delay gut repair by inducing #pyroptosis in intestinal epithelial cells via #gasdermin C upon ZBP1 activation! 1/n authors.elsevier.com/a/1k2OAL7PXqSL5

An exciting Halloween week for the Poltorak lab! Two successful PhD defenses in one week! Congrats David Jetton and @ZoieMagri ! Big thank you to outside examiners @MichelleKellih3 and @Lo_Zanzi for fabulous discussions! @TuftsGSBS

It was an exciting August in the Poltorak Lab! #Twisters @TuftsGSBS @ZoieMagri @CellReports

We found CD14 can switch Fas signaling from pro-death to pro-inflammatory! Check out our recent work in @CellReports to learn more. Congrats to first author @ZoieMagri! cell.com/cell-reports/f…

How does RIPK1 drive activation of caspase 8 in Yersinia infection?? Read our latest paper in @CellReports to find out! Congrats to first author David Jetton @TuftsGSBS cell.com/cell-reports/f…

Neurons repurpose death complex components to induce an anti-viral response during Zika virus infection. In her first preLight, @ZoieMagri covers recent work from the lab of @AndrewOberst. #preprint #preLight 👉 prelights.biologists.com/highlights/rip…

A recent preprint from the lab of @AndrewOberst demonstrates that neurons can repurpose death complex components to induce an anti-viral response to Zika! I’ve highlighted their work in my latest preLights post. Check it out! prelights.biologists.com/highlights/rip…

This symposium on #celldeath and survival will discuss exciting developments in this field including inflamed tissues and non-canonical #molecularpathways. Register for #Pathobiology2024 to attend this session! bit.ly/3TndnfK @Penn @TuftsUniversity @NotreDame @YaleMed

Cell death is essential to your health − an immunologist explains when cells decide to die with a bang or take their quiet leave bit.ly/3ZEKoWc

Check out this piece by one of our PhD students @ZoieMagri in the @ConversationUS ! Cell death is essential to your health − an immunologist explains when cells decide to die with a bang or take their quiet leave theconversation.com/cell-death-is-…

➡️Join us at the next BCDI meeting on Monday Oct 2nd at 3PM on the Harvard Med Quad (Goldenson 122) for exciting discussions with @chendi on inducing apoptosis in NSCLC and @nabel on identifying novel therapy targets in thymic epithelial tumors. More info: BostonCellDeath.org

Intriguingly, & consistent with the earlier work of @LabPoltorak (pnas.org/doi/10.1073/pn…), Jenna found that unlike in mouse macrophages, WT Yersinia fails to induce cell death in human IECs & macrophages, indicating that human cells are unable to undergo YopJ-mediated death. 4/n

➡️Join us at the next BCDI meeting on Monday Sept 11th at 3PM on the Harvard Med Quad (Goldenson 122) for exciting discussions led by @TheLeeLab on cell death in response to transcription blockade and @OylerYanivLab on cell death in infections. More info: BostonCellDeath.org