Weatheritt Lab

Excited to share our new review discussing potential of targeting isoforms as a new route to drugs with greater specificity and fewer adverse effects! nature.com/articles/s4157… Published in @NatRevDrugDisc Congrats @kjer_peter @GarvanInstitute @UNSWBABS @EMBLAustralia

Our analysis reveals that 29% of genes have multiple mammalian-conserved alternative transcripts, and >14% of m6A RNA modifications are conserved across mammals at the single nucleotide level. Together this highlights the conservation of RNA processing @UNSWBABS @EMBLAustralia

Here, we present a direct-RNA long read sequencing atlas, using @nanopore's PromethION, spanning over 230 million years of evolution. This atlas enables us to assess the conservation of coordinate splicing, m6A modifications, and transcript diversity.

Excited to share our latest paper biorxiv.org/cgi/content/sh… "The conserved landscape of RNA modifications and transcript diversity across mammalian evolution". Great work by @Gabeechuela and Akanksha in collaboration with @EduEyras Lab and the Shirokikh Lab.

The last part of my PhD research 🤓 is out!! If you are interested in RNA Biology -> Alternative Splicing and Epitranscriptomics + Evolution go have a look! A thread 🧵

I found this review on protein isoforms, derived from alternative splicing, very interesting 👉most genes produce multiple protein isoforms🧬🔄 👉isoforms can be tissue-/disease-specific 👉potential for therapeutic modulation or for biomarker discovery nature.com/articles/s4157…

Protein isoform-centric therapeutics: expanding targets and increasing specificity tinyurl.com/2v5c3us8 Many genes encode multiple protein isoforms. This new review discusses targeting isoforms as a route to drugs with greater specificity and fewer adverse effects

Finally, we discuss future perspectives and challenges relating to protein isoform-centric therapies. Thanks again to @kjer_peter @LabPhan

Lastly, we discuss how they can serve as sources of neoantigens in cancer, as unique molecular targets for directed drug delivery (both to kill cells or to tune their functions), and as diagnostic biomarkers

Excited to share our new review discussing potential of targeting isoforms as a new route to drugs with greater specificity and fewer adverse effects! nature.com/articles/s4157… Published in @NatRevDrugDisc Congrats @kjer_peter @GarvanInstitute @UNSWBABS @EMBLAustralia

Job Alert! Postdoc position is available in the Weatheritt lab in Sydney. An initial 2-year position working on RNA processing in early development. Work is in collaboration with Vi Wickramasinghe's lab at Peter Mac. Email me at r.weatheritt@garvan.org.au if interested.

Together this demonstrates the range of functional diversification created by alternative splicing in the proteome.

Finally, we discuss how the dysregulation of protein isoforms can contribute to and drive disease phenotypes: by the aberrant production of endogenous isoforms, altered activity of endogenous isoforms, or creation of disease-specific isoforms which rewire protein interactomes.

What is the function of alternative splicing in the proteome? What cellular functions does it impact? Our review (rdcu.be/dsryX) just published in @NatureSMB suggests splicing impacts almost every cellular process. Fantastic work by @kjer_peter! A short 🧵 below

Congratulations to Winton and Savannah, both from @UNSWScience, the two winners of our giveaway at the Sine-Dalgarno symposium this week at @JCSMR! Thanks to everyone who stopped by to chat with @SelvaKu55508618 and I this week! @Neuro_RNA

@TheCoxLab and @Coon_Labs scientists succeeded in developing a new method to generate a more detailed #proteome than ever before, providing insights into how #GeneticVariants and #SpliceVariants in humans impact the proteome. Published in @NatureBiotech nature.com/articles/s4158…

@Blencowe_Lab @Miller_MKWu congrats @Miller_MKWu !

Today, @Miller_MKWu successfully defended his PhD thesis after giving an excellent presentation of his work. Congratulations!