PralleLab

🚨 Second preprint of the week! We uncover the multiscale dynamics of active viscoelastic buckling in epithelia. We harness these mechanical instabilities for synthetic morphogenesis. Led by @onenimesa🙌. Theory by Marino Arroyo and team. biorxiv.org/content/10.110…

NIH grant awards plummeted $2.3 billion under President Trump statnews.com/2025/04/24/tru…

A new optical biosensor can probe the activities of native GPCRs in live cells, and, unlike typical sensors doesn’t interfere with downstream signaling and can be deployed in many cell types with only a single construct. scim.ag/4cno5L1 @scisignal

Sound-sheet microscopy is born! Congratulations to Baptiste Heiles, lab members and collaborators at the Shapiro Lab (Caltech) and Gazzola Lab (NIN/KNAW) for this scientific achievement 🚀.

In our new preprint, we study the physical aging of biochemically active condensates formed by an engineered Tau protein into disease-linked amyloid fibrils — and investigate whether small molecules can counteract this transition. @BanerjeeLab_UB biorxiv.org/content/10.110… 🧵1/3

Excited to share our work out in @CurrentBiology ! We find that SKAP's binding to microtubules *reduces* friction at the kinetochore-microtubule interface and increases attachment stability under force. Congrats to postdoc Miquel @RosasSalvans and all authors! With @Caleb_J_Rux and Moumita Das. sciencedirect.com/science/articl…

I found out this morning that my @NIH @NICHD_NIH F31 fellowship to study the biomechanics of uterine fibroids was CANCELLED.

We are thrilled to share this work linking specific human brain cell types to psychiatric and neurological disorders, out now in @NatureNeuro rdcu.be/d6Tcy See below for an overview and thanks to the amazing Tayden Li, @willgiardino, @deissero, and so many others!

@HillmanLab @PavelTomancak @StJude Exciting news. Huge congratulations!

Beyond excited to share my big @StJude news! We’re going to build an amazing hub for imaging technology development and deployment - driven by St Jude’s mission to transform the way the world understands and treats pediatric catastrophic diseases. Imaging innovators come join us!

@motifneuro @ARIA_research @JacquesCarolan Congrats!

We've been selected by @ARIA_research to develop a network of neural devices designed to monitor and regulate mental and cognitive states without brain surgery. The UK-based program led by @JacquesCarolan is contributing £69M to unlock the full potential of #neurotech.

Excited to share our new preprint! Exceptional work by postdoc @MikeLange identifies the first #LipidDroplet lipid quality control pathway! Droplet-localized FSP1 safeguards stored neutral lipids, blocking their peroxidation & #ferroptosis induction.🤩biorxiv.org/content/10.110…

SNAP-tag2: faster and brighter protein labeling biorxiv.org/content/10.110…

Interesting work by @JorgGrandl shows how Piezo1 shape affects nearby channels directly.

@JorgGrandl @NeuroCellPress Very interesting. Beautiful work. Congratulations to you and your team!

Just posted the most biologically important photopharmacology story we've had in the last few years. Ditched the photoswitch design principles we used for the last 10 years, & started all over again. And now it will work in vivo. doi.org/10.1101/2024.0… 🧵1/n🧵

Today in @ScienceMagazine we report how lipids specialize for life under the crushing pressures of the deep sea and what this means more broadly for the composition of cell membranes (1/n) science.org/doi/10.1126/sc…

Impressively strong magnetic effect on fluorescence of engineered protein Opens up new avenues for magnetogentics

@AndrewGYork Great work. Congratulations

Meet MagLOV: an engineered protein that responds STRONGLY to magnetic fields. This is a fluorescence timelapse of MagLOV in E. coli. We're waving a (small) magnet under the plate. Can you tell where the magnet is? Want some? It's on Addgene now! addgene.org/219957/

We used light to herd cell growth with @toettch lab! Optogenetics is pretty cool. Super fun collab. and exquisite data from @KevinSuhhh* and @RichardHT_*. Video: blue light pattern--> sheet of living tissue rearranges into creepy eye. See @toettch for🧵. biorxiv.org/content/10.110…