Rima Pathak MD
1K posts

Rima Pathak MD
@RimaPathak1
My passion for art, enthusiasm for travel and love for medicine that fulfills and satisfies my soul keeps me going!


Immune competence is partially encoded in the microbiome ➡️In a phase II trial in @Nature, a single oral FMT before immunotherapy led to high response rates (NSCLC ORR 80% with PD1 blockade; melanoma ORR 75% with PD1/CTLA-4). ➡️Benefit was not driven by donor engraftment, but by depletion of immunosuppressive taxa (Enterocloster, Clostridium innocuum) modulating tryptophan metabolism & CD8 T cell activity. Reintroduction of these taxa reversed the ICI benefit in vivo, supporting the microbiome as a modifiable therapeutic axis. 🤔We all know the microbiome matters, the real challenge is generalization. A European or Asian, etc microbiome is not the same & even within the same region, diet and lifestyle vary widely. The biology is convincing, translating it into broadly applicable cancer therapy is the hard part. doi.org/10.1038/s41591… @OncoAlert ➡️











































