Jay larssen
7 posts
@jay51289 @A_May_MD I think it's more a function of the more severe/more refractory patients in general in this trial. Absolute PBO rates can be influenced by patient severity, as it's less likely that a patient with intractable disease has a spontaneously better response than newly diagnosed.
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Absolutely KEY $ABVX point attached here that I have so far seen absolutely NOBODY mention.
Opportunity abounds.
Adam May@A_May_MD
Yes, small sample size but he’s also making the fallacy of equating equal sample sizes (patient number) to equal AE capture. Sure, the number of patients in the placebo arm was roughly equal to the 50mg arm, but 66% of the placebo arm patients dropped out of the study before completion, versus only 18% of the 50mg arm!!! This means the PATIENT YEAR sample from the placebo arm is likely ~half that of the $ABVX 50mg arm’s patient year sample. So, the placebo arm should naturally be EXPECTED to have a lower rate of cancers, even with the same starting “sample size”, and even with A DRUG THAT DOES NOT HAVE CANCER.
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@A_May_MD And what is the typical/expected placebo remission rate from other trials?
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@A_May_MD from the abvx press release: “The trial also recorded a 10.4% placebo clinical remission rate, the lowest reported to date in a Phase 3 UC maintenance responder re-randomization trial.” Does this mean the delta is artificially a bit higher due to a random placebo result?
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@AndrewRangeley @A_May_MD And what is the typical/expected placebo remission rate from other trials?
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@AndrewRangeley @A_May_MD from the abvx press release:
“The trial also recorded a 10.4% placebo clinical remission rate, the lowest reported to date in a Phase 3 UC maintenance responder re-randomization trial.”
Does this mean the delta is artificially a bit higher due to a random placebo result?
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Excited to have @A_May_MD back on the pod Monday. It's been a crazy week; we'll be talking all about what adjustments the Spurs can make to try to steal one from the Knicks at MSG.
Just kidding; we'll be talking $ABVX readout + $NKTR + all things bio.
Any questions for Adam?
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@matthewherper @ElvisCostello I said I’m so happy I could die. She said “drop dead” and left with another guy
cant top that
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My favorite @ElvisCostello lines:
“You make him sound like frozen food: his love will last forever.”
“She said that she was working for the ABC News. It was as much of the alphabet as she knew how to use.”
Yes, this is what I’m thinking about on my way to ASCO. I hope you’re happy now.
Stay tuned for more brilliant mistakes.
GIF
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@angie_rasmussen @NIHDirector_Jay But the illustrious scholar rob schneider is a must see
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I’d like to inquire whether the resolutely apolitical @NIHDirector_Jay still plans on speaking at TPUSA AmericaFest 2025 in December, given his fellow keynote speaker’s violent assassination while disseminating extremist right-wing political rhetoric
open.substack.com/pub/rasmussenr…
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