Noble Kumar

@UCPPNDept @UCincyMedicine @GradCollegeUC Congratulations Georgios

Congratulations to PhD student Georgios Siokatas! He won a travel award for his work "Inhibition of a cardioprotective miR family by cardiomyocyte KLF5 via 3 circular RNAs" at the 2025 American Heart Association Scientific Sessions. @UCincyMedicine @GradCollegeUC

As I’ve said multiple times , postdoc is the worst job you can have with a PhD in these times. I try hard to soften this blow for anyone in my lab and it barely scratches the surface..

@cohenlaboratory @ChihHsuanHsu1 @UNC_SOM Congratulations

It was great to finish off #UNCResearchWeek by seeing Sherry @ChihHsuanHsu1’s beautiful image on display in Bondurant Hall! @UNC_SOM 🔬🔬🔬

@OlzmannLab @ASBMB Congratulations James Olzmann.

Humbled and honored to receive the 2026 Avanti Award in Lipids from @ASBMB! Grateful to my exceptional lab, mentors, and collaborators for their support and inspiration. Excited to keep pushing the boundaries of lipid biology and therapeutics! asbmb.org/asbmb-today/pe…

Excited to share equal first author paper published in @JMCCardiology Full article link: jmcc-online.com/article/S0022-… Huge thanks to @KarthicK_PhD , @MattamUsho14047 and @kdrosato

6/ Huge thanks to the amazing team @nobletalari, @MattamUsho14047, Afra, Brook & collaborators! @UCPPNDept @UCincyMedicine @UCResearch @UCCOM_undergrad Read the full story: nature.com/articles/s4200… #OpenAccess #ScienceTwitter #MASH #LiverResearch

5/ Why this matters: Understanding these mitochondrial dynamics offers new insights into how hepatic energy metabolism adapts (or maladapts) in MASH. Could this open doors to novel therapeutic strategies?

4/ Morphological changes: Early MASH: PDMs became larger & more elongated. Advanced MASH: CMs became smaller & fragmented. 👉 This compartmentalization hints at mitochondrial specialization during metabolic stress.

3/ Key findings: PDMs = bioenergetic powerhouses, with higher pyruvate oxidation, TCA flux & oxidative phosphorylation protein complexes. CMs = shifted towards fatty acid oxidation, reflecting metabolic adaptation. Distinct mitochondrial functions drive MASH progression!

2/ What did we investigate? We examined cytoplasmic mitochondria (CM) and peridroplet mitochondria (PDM) in a diet-induced MASH mouse model. As MASH progressed, we observed an inverse relationship between these two mitochondrial populations!

1/ New paper alert! Excited to share our latest work on hepatic mitochondrial subpopulations and their distinct roles in MASH progression! 👉 Read here: nature.com/articles/s4200… #LiverResearch #Mitochondria #Metabolism #MASH #MASLD

we characterized the importance of hepatic PDM and CM, found that their content, dynamics, and bioenergetic capacities differentially altered from steatosis to fibrosis progression. Huge thanks to @MattamUsho14047, our PI @KarthicK_PhD  and the entire K lab team

Excited to see my another first author publication on hepatic mitochondrial subpopulations (Peridroplet mitochondria (PDM) and Cytoplasmic mitochondria (CM) @commBio. rdcu.be/eaoRj

@Mottillo_Lab Congratulations Emilio Mottillo

Had a great time in Munich at the Helmholtz Diabetes conference. It was an honor to be nominated for the HeIDi Young Investigator award and present our work. Wonderful meeting all the new people and connecting again with colleagues! t1p.de/4qbhh

The K lab had an amazing time at the 38th Annual Meeting of the Ohio Physiological Society (OPS)! 🎉 We presented posters and delivered oral talks. Huge congrats to @nobletalari for securing one of the top 5 Blitz Talk awards! 🏆

One of the most important issues of our time - particularly critical in the US

So excited to announce the publication of our research in @iScience_CP. Kudos to our postdocs, Noble Kumar Talari and Ushodaya Mattam, and our undergrads, Irene Sotomayor-Rodriguez and Afra Rahman. @UCPharmSysPhys @UCincyMedicine @MedSciMenon cell.com/iscience/fullt…

It is out! Here we describe a new method to isolate peridroplet mitochondria (PDM) from white adipose tissue (WAT), revealing unique functional characteristics in WAT PDM determined by lipid droplet size. life-science-alliance.org/content/7/2/e2…

@KarthicK_PhD @nih_nhlbi @UCPharmSysPhys @UCincyMedicine @UCResearch Congratulations Karthick…

Excited to share my journey! Submitted my first @nih_nhlbi R01 application and landed in the 10th percentile! Grateful for incredible mentors who guided me throughout. After overcoming personal challenges, this news is a sweet victory! @UCPharmSysPhys @UCincyMedicine @UCResearch

Happy to share our paper out in @NatureComms, in which we developed a method to isolate lipid droplet associated mitochondria from liver and showed it is bioenergetically different from cytosolic mitochondria population nature.com/articles/s4146…