polyousmath
1K posts

polyousmath
@polyousmath
building neuroplasters (link in bio) to learn stuff and exploring pharmacogenomics AI research as a hobby @PGAIR_Org.

in the last 24 hrs we have confirmed more speakers i never imagined possible batch 2 is going to be...quite insane






‘uncertainty tolerance’ is the greatest indicator of someone’s success


Mentally healthy people are often delusionally optimistic.







NEW EPISODE of HARD DRUGS! AlphaFold, ProteinMPNN and other AI tools are transforming biology and drug design. But how do they work? What can’t they do (yet)? And can we use them to make a vaccine against Strep A for the very first time? In this episode, Jacob and I talk about hacking proteins with AI. 03:21 What makes proteins cool 05:29 Can we make a vaccine against Strep A? 10:12 Proteins in nature aren’t enough, and we can improve them with AI 21:12 ProteinMPNN and AlphaFold are transforming drug design 29:52 A short history of protein structure prediction from physical models to deep learning 34:48 Using AI to design a Strep A vaccine 39:27 Validating an AI-designed Strep A vaccine 43:09 Recent AI protein breakthroughs 49:30 Why we don’t already have a Strep A vaccine and the future of optimizing protein drugs










