Reuben Philip

Previous submissions to @NikonSmallWorld. Dividing with too many centrosomes! #FluorescenceFriday #Centrosome

1/3 Lab #Preprint alert…A cool study led by @MullickSan22454 in collab with @ms_chirps lab showing how tubulin glycylation regulates ciliary motors and MAPs in vitro. @biorxiv_biochem. #glycylation #tubulinPTMs #cilia #Intraflagellartransport. Read more biorxiv.org/content/10.648…

In a study by Gori and colleagues, gene editing with a prime editor was used to treat two persons with chronic granulomatous disease caused by a small deletion in the gene NCF1. Full study results: nejm.org/doi/full/10.10… Editorial: Genetic Medicine — Primed and Ready nejm.org/doi/full/10.10… #Hematology

池尾聡さんと谷佑太さんの「“呼吸する”肺オルガノイド!?」がBiomaterials誌に掲載されました！ヒトiPS細胞由来の肺腺房様オルガノイドを初めて作製し、内部から膨らませ力学的な刺激を与え、その特性を計測できます。 sciencedirect.com/science/articl… プレス：iis.u-tokyo.ac.jp/ja/news/5038/ #Organoid #PAcinOs

PFA ependymoma is among the deadliest childhood brain tumors. And for years, one of the most striking mysteries was this: boys get it more often, and do worse. Nobody knew why. Now we do. Thrilled to share our new paper in @Nature : Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma Using scRNA-seq from 26 primary PFA tumors, we found that male tumors are shifted toward a more stem-like, less differentiated state — with a striking enrichment of gliogenic progenitor-like cells. In other words: male PFA tumors appear developmentally “younger,” stalled earlier along the glial differentiation trajectory. Then came the key mechanistic result. Using the four-core genotype mouse model — which cleanly separates sex chromosome effects from gonadal hormone effects. The answer was not chromosomes. It was androgen signaling. Androgens in the embryonic hindbrain delay glial differentiation, keeping progenitor cells immature for longer. That widens the developmental window for malignant transformation, offering a mechanistic explanation for both the male incidence bias and the worse outcomes. Even more exciting: this biology is actionable. The androgen receptor antagonist enzalutamide, already used in the clinic , and the AR degrader MTX-23 both suppressed PFA clonogenicity and growth. Other brain tumor subtypes were far less affected, suggesting this vulnerability may be unusually specific to PFA. A deadly pediatric brain tumor. A long-standing clinical mystery. And now, a developmental and hormonal mechanism that points toward therapy. Huge congratulations to co-first authors Jiao Zhang, Winnie Ong, and Alexandra Rasnitsyn, and to the entire international team from @BCMHouston @TexasChildrens @McGillU @UPitt and many collaborators worldwide. And a very special shoutout to Dr. Michael Taylor for leading this extraordinary project. Truly one of the best brain tumor researchers I know. Paper: nature.com/articles/s4158…

Chromosomes stuck behind the spindle are ticking time bombs for aneuploidy. We uncovered a mechanical rescue mechanism where microtubule pivoting repositions these high-risk chromosomes! Out last week in @NatureComms, here's a thread 🧵 shorturl.at/OD89x

(1/6): How can we better test therapeutics without using animals or risking lives? Lab-grown human mini-organs, called “organoids”, provide an answer! Despite their progress, organoids and related methods lack realistic flow through blood vessels, the “plumbing” of our bodies.

AI is cool and all... but a new paper in @ScienceMagazine kind of figured out the origin of life? The paper reports the discovery of a simple 45-nucleotide RNA molecule that can perfectly copy itself.

@JEFworks Incredible work

Inspired by some gesture-based point cloud controllers I've seen on here, I vibe coded a similar web app to explore the relationship between spatial, UMAP, and PCA embeddings for spatial transcriptomics data. Next level interactivity via🖐️ Try it out: jef.works/GestureGraph/

Introducing mScarlet3-S2: a highly photostable and bright red fluorescent protein. @Pingyong_Xu nature.com/articles/s4159…

Today in @Nature we report a new prime editing strategy that can rescue a common cause of many genetic diseases in a disease-agnostic manner. This approach converts a redundant endogenous tRNA into an optimized suppressor tRNA, enabling a single prime edit to rescue premature stop codons across different diseases. (1/15) drive.google.com/file/d/1bSvkJW…

an absolute shame. @harvard cutting PhD admissions "The Organismic and Evolutionary Biology department will shrink its class size by roughly 75 percent to three new Ph.D. students [...] Molecular and Cellular Biology will reduce its figure to four new students, and Chemistry and Chemical Biology will go down to four or five admits" thecrimson.com/article/2025/1…

My entry for today’s #FluorescenceFriday: a pupal #Drosophila testis with muscles expressing 🔵 Lifeact & 🔴 RFP-nls Honored & grateful to receive an honorable mention at @NikonInst Nikon Small World 🌍🔬✨ 🔗 nikonsmallworld.com/galleries/2025… #NikonSmallWorld #Microscopy #ScienceArt

Excited to share that my PhD thesis work is out in @ScienceMagazine today. We demonstrate robust rearrangement of the human genome using bridge recombinases, performing programmable insertions, excisions, and inversions at megabase-scale.

When the PI hasn't worked in at the bench in years but needs to do something in the lab for a photoshoot

Automated optogenetic control of hundreds of cells in parallel. Each cell is individually steered, collectively acting as a "tissue printer". Preprint & code out!

The brain is the master regulator of food intake and energy balance. A brilliant new @CellCellPress review, including the mechanism of GLP-1 drugs, by @ClemmensenC and colleagues, open-access cell.com/cell/fulltext/…

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by @US_FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe, rapidly progressing genetic disease... all in an astounding 7 months. Best of all, the infant patient shows apparent benefit. Congratulations to @kiranmusunuru, Rebecca Ahrens-Nicklas, and other team members for this heroic and inspiring effort, which has implications for the hundreds of millions of patients that suffer from thousands of genetic diseases. drive.google.com/file/d/1Jfku5j…

63 biliary cancer cell lines!! An unbelievable resource from the Bardeesy Lab @MGHCancerCenter