David Bishop (🦋 also bluespotscience.bsky.social)

Our latest work in @natureComms, led by @javi_iup: Sprint exercise disrupts mitochondrial ultrastructure, driving a unique mito stress response & remodelling in men go.nature.com/48yZIbJ supports targeted exercise prescriptions to achieve specific mito adaptations. Thread 🧵👇🏽

Acute exercise rewires the proteomic landscape of human immune cells in peripheral blood mononuclear cells (PBMCs): go.nature.com/40HG5uI

Great discussion with our research group on our upcoming projects investigating changes in mitochondria with ageing.

These findings highlight the importance of context-dependent , individualised training prescription to target specific physiological adaptations while accounting for individual and programme-level variables.

Adaptations were also influenced by how training was prescribed. Key moderating factors included: • exercise modality • HIIT interval duration • work-to-rest structure • total training volume In other words, “HIIT” is not a single stimulus.

Further to this, we conducted moderator analysis to examine whether the effects of HIIT vs. MVICT on all outcomes were consistent based on training status, age, sex, interval type, interval training intensity, and exercise modality.

However, we found no clear differences between HIIT and MVICT for: • metabolic thresholds • exercise economy • peak anaerobic power • overall physical performance Ie. On a group level, both training approaches produced comparable adaptations.

How does high-intensity interval training (HIIT) compare with moderate-to-vigorous continuous training (MVICT)? Our new meta-analysis synthesises 115 RCTs (n = 3196) across populations from sedentary adults to elite athletes. DOI: bit.ly/4rJXGgt Key findings below 🧵

Across the literature, on a whole group level, HIIT produced greater improvements in VO₂max than MVICT. HIIT also produced larger improvements in: • maximal aerobic power/speed • mean anaerobic power

We examined how HIIT vs MVICT affects: • VO₂max / VO₂peak • maximal aerobic power or speed • mean and peak anaerobic power • first and second metabolic thresholds • exercise economy • physical performance

HIIT has become one of the most widely promoted training strategies in both health & sports performance. This study provides the most comprehensive synthesis to date examining how HIIT vs MVICT influences multiple indicators of cardiorespiratory fitness.

Happy Italian Father's Day to all the dads out there. Thanks to the best kids in the world for the special afternoon together (and the cake!)

Great to see our statement “Physical Activity & Exercise Intensity Terminology” bit.ly/3NG2N3c & bit.ly/4nT7Pq5 generating some discussion (that was the goal!): bit.ly/4bxSNkH bit.ly/4bxSNkH bit.ly/3N9Fvmj bit.ly/4cU4PqQ

Exercise Intensity Terminology is a bit of a mess! I'll give a webinar the end of this week (free to ACSM members): bit.ly/4uta9Ys on our expert statement - “Physical Activity & Exercise Intensity Terminology” published bit.ly/3NG2N3c & bit.ly/4nT7Pq5

New paper in Science bit.ly/40xEtUg shows that daily movement & sleep patterns before "mid-life" in killifish can predict lifespan. Longer-lived fish moved more vigorously during the day & kept sleep tightly confined to nighttime hours.

Stoked to already have > 12 submissions to our Special Collection: Physical Activity & Mental Health: From Mechanisms to Global Implementation go.nature.com/4p5o3wD Thanks to our amazing team of guest editors - @BrendonStubbs23 @KMachaczek @simon_rosenbaum & Dr.P.S.Indu

Great to hang out with our research group and plan some "Big Ideas" for the year ahead.

A reminder to submit to our Special Collection: Physical Activity and Mental Health: From Mechanisms to Global Implementation go.nature.com/4p5o3wD An amazing team of guest editors - @BrendonStubbs23 @KMachaczek @simon_rosenbaum & Dr.P.S.Indu & many great submissions already

#footballresearch 4/2026 footballscience.net/2026/02/18/lat… @seamusmccaff @Peter_Edholm @BlueSpotScience @rggonzalo @IrineuLoturco @DrAnthonyWeldon @OliverFaude @SigridOlthof @lemonwatcher @AlexMEhlert @CiDeely @jcissik @hadi_nobari @Marco_Cardinale @MovTcoach @Van_Bassios @adeburca11 @sis

Sponsor highlight! Who is that hot new journal on the block? Its Nature Exercise Medicine and Health! Present your work at #IBEC2026 and then publish it!! Editors: @BlueSpotScience @2ajm @mackinprof @simon_rosenbaum @ZhenYanLab nature.com/npjexercisemed/