David Bishop (🦋 also bluespotscience.bsky.social)

Our latest work in @natureComms, led by @javi_iup: Sprint exercise disrupts mitochondrial ultrastructure, driving a unique mito stress response & remodelling in men go.nature.com/48yZIbJ supports targeted exercise prescriptions to achieve specific mito adaptations. Thread 🧵👇🏽

Resistance-only and concurrent exercise induce similar myofibrillar protein synthesis rates and associated molecular responses in moderately active men before and after training bit.ly/3QWDye8

Single‐Nucleus RNA Sequencing Reveals Muscle Fiber Cell Heterogeneity During Human Skeletal Muscle Aging bit.ly/4cXx5Iu

#footballresearch 13/26 footballscience.net/2026/04/22/lat… @acea_ngel @BlueSpotScience @seamusmccaff @at_performance7 @OliverFaude @PeterKrustrup @JDoradopf @IrineuLoturco @Peter_Edholm @coach_roche_ @rggonzalo @CiDeely @joseromeropf @andresace260695 @DrAnthonyWeldon @michaelm_1978 @sis

Cardiopulmonary and skeletal muscle strategies underlying exhaustive exercise in adults with glycogen storage disease type III bit.ly/4tNEaRv

One night of sleep deprivation in FLIES increases the expression of genes that encode proteins with roles in mitochondrial respiration & ATP synthesis, along with mitochondrial fragmentation & enhanced mitophagy go.nature.com/41EB4Ua

Lots of interest in this study showing that Rapamycin fails to boost muscle gains from exercise in older adults: bit.ly/4tOdGiK

#footballresearch 12/26 footballscience.net/2026/04/16/lat… @IrineuLoturco @andresace260695 @at_performance7 @michaelm_1978 @BlueSpotScience @DrAnthonyWeldon @CiDeely @Peter_Edholm @fitsoccerqueen @PeterKrustrup @efthimis400 @jaron_michal @Van_Bassios @Fabio_belkacem @sis @MattAllenSpSci

Review by @JamesRBroatch on the Influence of Post-Exercise Cold-Water Immersion on Adaptive Responses to Exercise: bit.ly/4ttx9WB

#footballresearch 11/2026 footballscience.net/2026/04/13/lat… @IrineuLoturco @OliverFaude @joseromeropf @SergioMinuto90 @LConnorCoaching @hadi_nobari @michaelm_1978 @GleesonEileen @B_V_Goncalves @GarrisonDraper @BlueSpotScience @Peter_Edholm @ajbeardo @CiDeely @DrAnthonyWeldon @west_jules

Submissions now open for our Special Collection "Exercise and Healthy Ageing" go.nature.com/4tFFqWL Amazing team of guest editors: @mikelizquierdo_ @MVFranchi @csbd7 & Luis Penailillo

Nice summary of how mitochondria sense and control metabolites, and respond to metabolic stresses: bit.ly/4elgzTI

New study suggests that exercise induces sex-specific assembly of mitochondrial supercomplexes bit.ly/4txIpRk It would be cool to see if this still occurs in ♂ & ♀ matched for training volume.

@doctorinigo @D_Morales_Alamo Lactate is not shown in the one figure I included in the tweet, but is mentioned by the authors in numerous places throughout their review.

Nice review that reflects a traditional, pathway-based view of metabolism, but misses the molecule that actually integrates the system. Lactate is a primary oxidative fuel, a regulator of redox balance, coordinator of metabolic flux and the main regulator of intermediary metabolism. The continued omission of lactate in mainstream bioenergetics papers is not a minor detail, it is a conceptual gap. In 2026, discussing cellular metabolism without mentioning lactate is equivalent to discussing diabetes without mentioning insulin.

Nice summary of how skeletal muscle mitochondrial fuel utilisation is regulated during exercise bit.ly/419A7CU

Exercise training induces mitochondrial biogenesis, while high-fat diet increases the ability of mitochondria to use long and short-chain fatty acids bit.ly/4seYBFR

I’m thrilled to share one of the studies from my PhD, which has just been published in @PNASNews 🤗 “Mitochondrial remodeling in skeletal muscle underlies exercise-induced reversal of age-associated functional decline in mice and humans” 🔗👇🏼 pnas.org/doi/10.1073/pn…

Submissions open for our Special Collection "Nutritional strategies to optimise the health outcomes of physical activity and exercise interventions": go.nature.com/4sxUXId which explores how nutritional strategies can complement the benefits of exercise. @LDeldicque

Markers of mitochondrial function and oxidative metabolism in skeletal muscle do not display intrinsic circadian regulation in female mice bit.ly/3PJCJ8f

Serum metabolomic signatures for high-, moderate-, and low-intensity exercise. bit.ly/4cchdR8