Jamie Chu

Excited to share the 3rd first-author paper from my PhD! This was a collaborative effort from @JimJohnsonSci @nictitate @WyWyWa labs. A big thank you to everyone who participate and to CIHR and Breakthrough T1D Centre of Excellence at UBC for funding! biorxiv.org/content/10.110…

🚨The @SoleimanpourLab is hiring!!! 🚨 If you or someone you know is looking for a post-doctoral position and interested in studying mitochondria and diabetes, please get in touch (or RT)!

Dr. Johnson's (@JimJohnsonSci) lab identified the two Ins2 gene activity states in intact isolated islets and showed that cells in the same state were more likely to be nearer to each other. 🧫 @iScience_CP | bit.ly/413zWsn

@Ella_Maru @JimJohnsonSci @nictitate @WyWyWa Thanks for the question Ella! Unfortunately, we don’t know the answer to that, as we did not run experiments with primary beta cells. But it would most certainly be an interesting area to explore!

@CMJamieChu @JimJohnsonSci @nictitate @WyWyWa Congratulations Jamie! Is insulin gene activity in SC-β cells more stress-sensitive than in primary β cells?

Excited to share the 3rd first-author paper from my PhD! This was a collaborative effort from @JimJohnsonSci @nictitate @WyWyWa labs. A big thank you to everyone who participate and to CIHR and Breakthrough T1D Centre of Excellence at UBC for funding! biorxiv.org/content/10.110…

New from @JimJohnsonSci & colleagues. Novel insights into the proteomic profiles and regulation of β cell states through analysis of cells varying in Ins gene activity #islets #diabetes @cp-iscience.bsky.social cell.com/iscience/fullt…

Congrats Jamie and all the collaborators on another fun project. We are learning lots about pancreatic beta cell states that are marked by low vs high insulin production.

7/ Overall, this study utilizes a novel method for prioritizing screening targets using omics datasets from SC-beta cells and human islets. We reveal new ways to protect SC-beta cells for type 1 diabetes cell therapy.

6/ We then compared each ligand across multiple doses, and found that the protective effects of FGFs were dose dependent. Of the FGFs, FGF4 the strongest effects across all concentrations tested.

4/ We found that cytokine induction reduced EGFP fluorescence (INS gene activity), and that this effect was also rescued by the FGFs.

3/ We found that of ~150 ligands screened, members of the fibroblast growth factor family had strong protective effects against cytokine-induced SC-beta cell death, in particular FGF4, FGF5, FGF8F, FGF19, and FGF21.

We are looking for an imaging master to run a very cool shared microscope that will be unique to Canada - Raman label-free, 2-photon, FLIM, high-res, fast capture, thick live tissue, organoids, high-content screening. We are a dynamic and supportive and fun environment.

@LickertHeiko @JohannaSiehler @BilekovaSara Congratulations Heiko!!

Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”. doi.org/10.1038/s42255… A tremendous collaborative effort led by @JohannaSiehler, @BilekovaSara and other members of the @LickertHeiko lab.