Scott Soleimanpour

Delighted to share our latest now published in@NatureComms, where we found a new role for mitochondrial programming of SC-β cell fate through PPARα! We're excited for the potential to target mitochondria to improve SC-islets to treat #T1D! nature.com/articles/s4146…

The human alpha cell's competence to secrete glucagon depends on paracrine inhibitory input from beta (serotonin [5-HT], γ-aminobutyric acid [GABA]) and delta (somatostatin [SST]) cells #islets cell.com/cell-reports/f…

High intensity interval training HIIT identified as a potent stimulus for improving muscle oxidative and metabolic health in type 2 #diabetes in part via expanding muscle mitochondrial cristae density link.springer.com/article/10.100…

Excited to share our work at @MitOtalks this Thursday, March 5th! Hope to see you there!!

🚨Dear Twitter friends, we need your help to advance in 2026 STAT Madness, the March Madness of Science tournament! 🏀🧪 Please vote for our Univ of Michigan Caswell Diabetes Institute team in your bracket before Mon March 9. Thank you! 🙏 statnews.com/feature/stat-m…

Taken too soon Prof Ross Laybutt @DiabetologiaJnl @EASDnews link.springer.com/article/10.100…

It's here! It's here! Meet the teams competing in #STATMadness 2026! trib.al/DzdrZpI

NIH is not issuing awards. You may think that it's because they it is coming up with new directions of research...The apposite is true. Here is a graph showing how many fewer new funding opportunities that NIH has posted over time. -91%, a trend that started on Jan 2025.

SEL1L-HRD1 endoplasmic reticulum (ER)-associated degradation (ERAD) is a regulator of PC2 biology and an essential mechanism for maintaining α cell function and glucagon biosynthesis nature.com/articles/s4146…

Thrilled to share our work "Recessive PPTC7 deficiency triggers excessive mitophagy to cause a severe inborn error of metabolism with hypomyelinating leukodystrophy" - a collaborative effort documenting the first cases of PPTC7 mutations in humans. 1/n researchsquare.com/article/rs-881…

Excited to share that my PhD work on ER mito contact sites is finally out at @MolecularCell! Big shout out to @stark2_d to take this across the finish line, and @YatrikShahLab and @LyssiotisLab for their guidance as always!

Should the National Institutes of Health be abolished? Of course not. Never thought I’d ever have to debate that resolution, but I will on March 4, @TheSohoForum.

CDMRP decisions dropped today. They funded 19 grants. Total. For the whole program. 1.9%. Not sure how anyone is supposed to survive this kind of environment.

Introducing the inflammatome, a comprehensive set of 2,000 genes consistently upregulated in various inflammatory diseases vs. healthy controls. cell.com/cell-reports/f…

Exciting new work for the early detection of T1D onset from my colleague Lonnie Shea's lab here at Michigan! Happy to have played a small role. #GoBlue

Leaders and hubs! Join us this Thursday 1/29/26 for @L_F_D_S presentation on beta cell calcium dynamics

In children with stage 1 #T1D, 1 year of high-dose oral insulin did not alter progression to dysglycemia or #diabetes or immune response to insulin diabetesjournals.org/care/article/d…

The authors propose that targeting mitochondrial dNTP transport may offer a therapeutic strategy to mitigate #obesity induced inflammation and its associated diseases science.org/doi/10.1126/sc…

Joel Habener pioneer in molecular biology, mentor, led foundational research that discovered a hormone dubbed GLP-1, which would later become the key ingredient in Ozempic and Mounjaro ⁦@MassGeneralNews⁩ ⁦@TheEndoSociety⁩ ⁦@Harvard⁩ wsj.com/health/pharma/…

February 2025’s top Health Lab story explored how mitochondria - the cell’s power source - may play a key role in diabetes and future treatments. michiganmedicine.org/health-lab/mit… @SoleimanpourLab

So much to celebrate this year! This week, the lab donated boxes full of gifts for 3 young children through the Salvation Army as we gathered for our holiday party. Our hearts (and stomachs) are full! ❤️ We can't wait to make new advances for patients with diabetes in 2026! 🥳