Scott Soleimanpour

Delighted to share our latest now published in@NatureComms, where we found a new role for mitochondrial programming of SC-β cell fate through PPARα! We're excited for the potential to target mitochondria to improve SC-islets to treat #T1D! nature.com/articles/s4146…

@RPC_3312 Congrats Ram and team! Phenomenal new work!!!

Very happy to share our new paper. Together with our wonderful collaborators, we found that L-2-HG, a metabolite often viewed as “toxic,” also has an essential physiological function in mice. nature.com/articles/s4158…

Congratulations to Chandel lab for demonstrating that a metabolite once considered purely “toxic” may actually be a key signaling molecule in cells and organisms. This study demonstrates that l-2-HG functions in signaling by regulating epigenetic state via KDM4/H3K9me3 demethylase and linking redox state to transcriptional repression. The study provides initial words in “Metabolic Language” of transcription. nature.com/articles/s4158… @NU_BMG_SQE @NUFeinbergMed @Nature @CellPressNews @ScienceMagazine @MolecularCell @theNASciences @theNAMedicine @NorthwesternU @NatMetabolism

We are once again recruiting at all levels! See links for postdoc tinyurl.com/36bttteu and technician tinyurl.com/3ycemtdt position ads. Read more about our research in our latest preprint biorxiv.org/content/10.648… and on our website worthamlab.org.

The fascinating biology of targeting nuclear receptor ligands to GLP-1 receptor + cells continues, with the latest chapter studying GLP-1 E2 in NOD mice, with or without low dose aCD3 @DiabetologiaJnl #Sec" target="_blank" rel="nofollow noopener">link.springer.com/article/10.100…

@DarioFDeJesus @UMIntMed @adina_turcu @the_asci Thank you so much, Dario!!!

@UMIntMed @SoleimanpourLab @adina_turcu @the_asci Many congratulations!

Congratulations to Drs. @SoleimanpourLab and @adina_turcu, who were recently inducted into The @the_asci! Learn more about the society and their research at beta.the-asci.org.

@ErickaHuds44202 Thank you so much!

Congratulations @SoleimanpourLab!!

The Crewe lab is looking for a postdoc to study adipose extracellular vesicle signaling in cardiovascular disease. Send me an email if you are interested!

Join us May 12 for the 2026 Saltiel Life Sciences Syposium: Decoding GLP-1s! This full-day event will explore the fundamental cellular mechanisms behind the new generation of hashtag#GLP1 therapeutics, as well as ongoing efforts to improve them. Speakers include @AmberAlhadeff, @DanielJDrucker, @TimoMueller_IDO, Martin Myers, @tunepers , @seeleyrj and @thewilliamslab

We mourn the passing of Gordon Weir, a towering figure in the field of diabetes, and valued colleague and friend of countless members of the @JoslinDiabetes and @Harvard diabetes communities. legacy.com/us/obituaries/…

At this link, you can watch the brilliant lecture by Helen Hobbs today on the topic: Genetic Disorders of Dietary Excess: Getting to the Heart of the Matter. An exquisite example of the power of medical research by a great physician-scientist. vimeo.com/1181585757

Congratulations to Dr. @DanielJDrucker, a 2026 Governor General's Innovation Award laureate! 🏅 This award celebrates Canadians who improve lives through innovation & Dr. Drucker's GLP-1 & GLP-2 discoveries have done exactly that. Learn more ➡️ bit.ly/4sZZ53N

GLP-1 medicines and #pancreatitis After 21 years, lots of smoke, no fire. Here a look at Tirzepatide sciencedirect.com/science/articl…

I’m a lipid biochemist by training and for 20 years I have been saying: The lower the LDL-C the better for you. nejm.org/doi/full/10.10…

Once weekly basal #insulin icodec approved for adults with type 2 #diabetes @US_FDA novonordisk.com/content/nncorp…

What a fun surprise to find that our work has been featured in a @JCellBiol spotlight!! Many thanks to Carlotta Peselj and Nora Vögtle for the great write up!

New website alert! We are transitioning to our dedicated site isletrss.org for weekly seminar announcements and communications. Thank you for your support as we retire this Twitter/X account. See you there!

The human alpha cell's competence to secrete glucagon depends on paracrine inhibitory input from beta (serotonin [5-HT], γ-aminobutyric acid [GABA]) and delta (somatostatin [SST]) cells #islets cell.com/cell-reports/f…

High intensity interval training HIIT identified as a potent stimulus for improving muscle oxidative and metabolic health in type 2 #diabetes in part via expanding muscle mitochondrial cristae density link.springer.com/article/10.100…

Excited to share our work at @MitOtalks this Thursday, March 5th! Hope to see you there!!