CarlssonLab

Sign up for the GPCR workshop at AstraZeneca (Gothenburg), 26th of May 2026! scilifelab.se/event/challeng…

"AlphaFold3 fails to model receptor-ligand complexes for understudied targets" nature.com/articles/s4146…

Ultra-large virtual screening discovers agonists of the orphan receptor GPR139, a target for schizophrenia. AlphaFold3 fails to model receptor-ligand complexes for understudied targets! New paper: nature.com/articles/s4146… @NatureComms @UU_University @Scilifelab

Ultra-large virtual screening unveils potent agonists of the neuromodulatory orphan receptor GPR139 nature.com/articles/s4146…

@CarlssonLab proves it: GPCR modeling only works with real collaboration—chemists, pharmacologists, modelers in sync. 🎧 Hear how it’s done: ecosystem.drgpcr.com/dr-gpcr-podcas… #DrGPCR #GPCR #TeamScience #DrugDesign

“Explain” is outdated. Can your model predict a GPCR response? @CarlssonLab at Uppsala builds models with the goal to guide real experiments. 🎧 ecosystem.drgpcr.com/dr-gpcr-podcas… #DrGPCR #GPCR #MolecularModeling #DrugDiscovery

Control duration, penetration & PK/PD separation. Plus: Jens Carlsson on predictive modeling + this week’s Premium sneak peek. Read & share ➤ bit.ly/3KVlL4m #DrGPCR #GPCR

@CarlssonLab failed at the bench and found his calling in modeling. Now his lab predicts GPCR-ligand outcomes before they’re tested. 🎧 Hear his story: ecosystem.drgpcr.com/dr-gpcr-podcas… #DrGPCR #GPCR #CareerInScience #ComputationalBiology

Carlsson lab kick off!

Our recent work was highlighted in @NatRevDrugDisc ! Read more at: nature.com/articles/d4157…

Just published in PNAS: Our structure-based virtual screening approach to identify allosteric modulators of G protein-coupled receptors (GPCRs): pnas.org/doi/10.1073/pn…. Great collaboration between @MonashUni and @uppsalauni.

Biased adrenergic agonists – a novel treatment for diabetes! Amazing paper in Cell from a project led by @ProfBengtsson (Stockholm Uni) and Shane Wright (Karolinska Inst): cell.com/cell/fulltext/… Great work by my student Nour Kahlous, who performed simulations of the compounds.

Cool cover designed by Damian Bartuzi in my group. Read the paper too! (pubs.acs.org/doi/10.1021/ac…). Great collaboration with Rob Lane's lab.

@pwk2013 For dessert!

@CarlssonLab No rotted herring?

Lab BBQ, including chicken feet and Bánh mì.

Article: Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D2 Receptor #research supported by Knut and Alice Wallenberg Foundation #KAW100 #Parkinsons #Dopamine @CarlssonLab @ACSPublications tinyurl.com/ycxdkcum

Allosteric modulators of D2 - we're coming for you! Read our latest paper on where allosteric modulators of the D2 dopamine receptors bind - new strategy for treating Parkinson's disease? pubs.acs.org/doi/10.1021/ac…

AI meets rapid antiviral design. We used EvoBind to design a cyclic peptide HIV-1 inhibitor in a single shot to a novel interface, directly from sequence. Low micromolar activity, no toxicity, no structural data needed. biorxiv.org/content/10.110…