Cenik Lab

Ribo-ITP enables ribosome occupancy measurements from single cells. Our first application revealed insights into allele-specific ribosome engagement in early development (nature.com/articles/s4158…). #RiboITP #singlecell

@arjunrajlab Earlier this summer I came across this and recommended to a new student in the lab: courses.ibiology.org/catalog/PYSJ/S…

In our new preprint, we integrated three multiplexed assays of variant effect to profile several layers of gene expression for thousands of variants in COMT! biorxiv.org/content/10.110…

@hagentilgner Thanks Hagen, Hope all is well!

This looks so amazing. I have to rearrange my Monday to read it! Congrats @CenikLab !

@DrJoshBlack Thanks Josh!

Congrats @CenikLab on the publication! Excited to see it in print!

Intrigued by the potential of Ribo-ITP in uncovering the intricacies of cellular translation? We're seeking motivated postdocs to join our team, we'd love to connect with you!

Through collaborations, we're applying Ribo-ITP to diverse areas like early mouse limb development, brain organoids, immune cells, and rare cancer cells. If you are interested in adopting Ribo-ITP, here is our step-by-step protocol with video instructions: ceniklab.github.io/ribo_itp/

Ribo-ITP enables ribosome occupancy measurements from single cells. Our first application revealed insights into allele-specific ribosome engagement in early development (nature.com/articles/s4158…). #RiboITP #singlecell

@johnprensner Thank you! If you would like to try Ribo-ITP with your favorite system, we would be happy to help!

@_taktas_ @MatthewKraushar thanks! Let me know if we can participate in the journal club via zoom :)

@CenikLab @MatthewKraushar Congratulations Can 🎉 It looks very interesting, we should do a journal club on this.

super cool work from @CenikLab with single-cell Ribo-seq (RIBOsome profiling via ITP; Ribo-ITP) applied to early mouse development full of clever maneuvers (allele/parental SNPs) & striking observations for gene expression (RNA:RPF:protein eg. Fig S8) nature.com/articles/s4158…

@bulutkarslioglu @MatthewKraushar Thank you!

@CenikLab @MatthewKraushar Congrats Can! Awesome work 🎊

@wu_xuebing Not sure about the timeline for availability as a kit or service. However, several labs have successfully adopted it. If you are interested, we would be happy to help you get started!

@CenikLab Congrats Can! Any comment on when Ribo-ITP will be available to labs like mine? either as a kit or as a service

ribosome profiling in 30min, and single cells! amazing work from @CenikLab nature.com/articles/s4158…

We are happy to unveil our latest published work where we describe how the metabolic enzyme, Pyruvate Kinase (PKM), regulates global mRNA translation in human cells. Here's a short 🧵... academic.oup.com/nar/advance-ar…

Our study showing that Hedgehog signaling is essential for maintaining the early foregut and larynx by preventing EMT was published: doi.org/10.7554/eLife.… @eLife. This was led by recent @UTexasILS graduate Janani Ramachandran with help from Hongkai Ji @jihk99 and @ZornLab.

Congratulations to the 2022 @UT_iGEM team for winning the the Best Foundational Advance award at the iGEM Grand Jamboree! They were also a top 10 overall undergraduate team, finalists for Best Presentation and Best Part Collection, and awarded a Gold Medal. @ut_mbs @TexasScience

Our 1st effort into dissecting the crosstalk between #autophagy & other vacuolar trafficking pathways, now out in @JCellBiol Thx to everyone involved!

Hypodermal ribosome synthesis inhibition induces a nutrition-uncoupled organism-wide growth quiescence in C. elegans biorxiv.org/content/10.110… @SarinayElif

🌮BioTACOS tomorrow, Mon Oct 17, 2022 9:30 am- 🌮 "RiboBase: A comprehensive databse of ribosome profiling data" by Hakan Ozadam in @CenikLab Please join in!