Journal of Cell Biology

Articles in our latest collection focus on the roles of ATG9 and LC3 interacting regions, plus mechanisms of selective #autophagy involving Rab GTPases, #mitophagy, and #pexophagy. 👉 hubs.la/Q040Nfh60

Deb Roy, Inoue et al. @JohnsHopkins introduce an #optogenetics tool to rapidly induce #microtubule acetylation in living cells and show that this triggers release of the RhoGEF GEF-H1 from #microtubules, thereby driving persistent directional cell migration. #Cytoskeleton

Agarwal, Zaidel-Bar et al. define the stage-specific gene expression programs of a leader cell that drives collective tissue invasion during organ #development, identifying membrane #trafficking as a central regulator of leader cell behavior. hubs.la/Q047HlNL0 #Migration

Stalder, Pereira, Gershlick et al. @Cambridge_Uni uncover new regulators of #Golgi-to-plasma membrane transport, showing that a PTPN23-dependent #ESCRT pathway is essential for secretion of membrane & soluble cargoes, including hormones & antibodies. hubs.la/Q047kBDt0

Spotlight: Lwin & Yap highlight work from Soffer et al. (hubs.la/Q0476_0_0), which suggests that #spectrin mediates the integration of transitions in cell shape with spatial organization signaling by acting as an organizer of the #actomyosin cortex. hubs.la/Q0476_t_0

Articles in our latest collection focus on the roles of ATG9 and LC3 interacting regions, plus mechanisms of selective #autophagy involving Rab GTPases, #mitophagy, and #pexophagy. 👉 hubs.la/Q046m__Y0 #GRC

@nani_grotjahn Read 📄 "Cytoplasmic ribosomes on mitochondria alter the local membrane environment for protein import" from the Grotjahn lab: hubs.la/Q0442jjR0

“Being highlighted by JCB affirms that this integrative approach is both valued and necessary” — Dr. Danielle Grotjahn (@nani_grotjahn) JCB is where the world meets your research. Learn more 👉 hubs.la/Q045fxDc0

The p97 ATPase and its adaptor UBXD8 maintain #peroxisome pools by preventing #pexophagy. From Iris Montes, Malavika Raman @maliramanlab and colleagues: hubs.la/Q046m-7k0 📕 Part of #Autophagy 2026 👉 hubs.la/Q046m-s40 #GRC

ATG9A facilitates closure of mammalian autophagosomes. From Ruheena Javed, Vojo Deretic @vpderetic and colleagues: hubs.la/Q046m_mK0 📕Part of #Autophagy 2026 👉 hubs.la/Q046mYn10 #GRC

The #mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to #mitochondria. From Yamashita, Arai, Kanki, Waguri and colleagues: hubs.la/Q046n1yc0 📕Part of #Autophagy 2026 👉 hubs.la/Q046m_NY0 #GRC

Trachsel-Moncho, Simonsen et al. identify the endosomal protein SNX10 as a modulator of piecemeal #mitophagy of OXPHOS machinery components and mitochondrial homeostasis. hubs.la/Q046m_df0 📕Part of #Autophagy 2026 👉 hubs.la/Q046mRVN0 #GRC

In this Perspective, North, @shoemaker_lab et al. highlight the rapidly expanding role of LC3-interacting regions in autophagy. hubs.la/Q046n05v0 📕Part of #Autophagy 2026 👉 hubs.la/Q046n1Jn0 #GRC

Wei Zou & Qiming Sun labs uncover Rab #GTPases as evolutionarily conserved signals mediating selective #autophagy, targeting damaged #mitochondria, #LipidDroplets, and #pathogens for degradation hubs.la/Q046n2sY0 📕#Autophagy 2026 👉 hubs.la/Q046mZLL0 #GRC

The #autophagy protein ATG-9 regulates #lysosome function and integrity. From Kangfu Peng, Hong Zhang and colleagues (Institute of Biophysics, CAS): hubs.la/Q046m_kD0 📕 Part of #Autophagy 2026 👉 hubs.la/Q046mYqt0 #GRC

SOD1 is delivered to #lysosomes via #autophagy to maintain lysosomal function and integrity. From Yanzhe Zheng, Ruilin Tian, Yan Zhao and colleagues: hubs.la/Q046mRyh0 📕 Part of #Autophagy 2026 👉 hubs.la/Q046mY150 #GRC

PEX14 acts as a molecular link between optineurin and the autophagic machinery to induce #pexophagy. From Hongli Li, Marc Fransen and colleagues (KU Leuven): hubs.la/Q046mRsv0 📕 Part of #Autophagy 2026 👉 hubs.la/Q046mP8y0 #GRC

A Rab1 interactome illuminates a dual role in #autophagy and membrane #trafficking, say Alexander R. van Vliet, Sean Munro and colleagues hubs.la/Q046MkyB0 📕 Part of #Autophagy 2026 👉 hubs.la/Q046Mdb20 #GRC

Bacterial CipB is an exogenous receptor to drive the #mitophagy-TFEB axis and promote pathogenesis. From Shuai Liu, Shan Li and colleagues (Huazhong Agricultural University): hubs.la/Q046mZGJ0 📕 Part of #Autophagy 2026 👉 hubs.la/Q046mRY90 #GRC

Audra M. Rogers, Martin J. Egan et al. @UArkansas demonstrate that heat stress triggers nucleolar remodeling in filamentous fungi, enabling segregation of damaged material and selective inheritance of a new nucleolar compartment. hubs.la/Q046JV4H0

To accompany the @GordonConf #Autophagy #GRC, explore our recent special collection, incl. the role of ATG 9 in autophagosome formation & the regulation of lysosomal function, and the regulation of selective autophagy, incl. #mitophagy and #pexophagy 👉 hubs.la/Q046mVPG0