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New manuscript from the lab on @cddpress " H263A and SCAN1/H493R mutant TDP1 block TOP1-induced Double-Strand Break Repair during gene transcription in quiescent cells and promote cell death". rdcu.be/eSxtG @ibis_sevilla @InvestigaUS
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Fernando Gomez-Herreros Lab
717 posts
Fernando Gomez-Herreros Lab
@FGH_Lab
DNA repair and Gene Expression in human disease. Andalusian research group. Find us at @IBiS_Sevilla
Seville, Spain 가입일 Mayıs 2016
681 팔로잉647 팔로워
Muy contentos y agradecidos de que el último trabajo del laboratorio haya sido seleccionado como artículo del mes por la @SEBBM_es !!🎉🎉 @ibis_sevilla @InvestigaUS
SEBBM@SEBBM_es
#ArtículodelMes H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death Por @Diana_Rubio_ et al. f.mtr.cool/cybufwyhmj
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Fernando Gomez-Herreros Lab 리트윗함
Our Science paper is out! 😀 Enjoy if you like SPRTN, DPCs, Innate immunity and Aging.
science.org/doi/10.1126/sc…
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Fernando Gomez-Herreros Lab 리트윗함
Excited to see our research published!! 🎉
Amazing project in @FGH_Lab at @ibis_sevilla, @unisevilla
"H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death"
nature.com/articles/s4141…
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A terrific work of @diana_rubio and @hidalgogarciaD with the support of all the lab. @josefra1975 @E__GranadoCalle
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These results support the potential role of TOP1-induced DSBs as a main contributor to certain hereditary neurological syndromes.
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New manuscript from the lab on @cddpress " H263A and SCAN1/H493R mutant TDP1 block TOP1-induced Double-Strand Break Repair during gene transcription in quiescent cells and promote cell death". rdcu.be/eSxtG @ibis_sevilla @InvestigaUS
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Fernando Gomez-Herreros Lab 리트윗함
Un estudio del Instituto de Biomedicina de Sevilla desvela un nuevo mecanismo de sensibilidad del sarcoma de Ewing a la quimioterapia #Sevilla #SevillaHoy ddsevilla.info/rbr9b1
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Grateful to all collaborators who made this work possible!
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👉EWS::FLI1 modulates R-loop metabolism via DHX9, driving increased vulnerability to TOP1-targeting agents.
👉Targeting TOP1 in EWS cells destabilizes the genome and provokes strong replication stress and cell death in EwS cells and tumors
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Our latest study is now online at @oncogenejournal pubmed.ncbi.nlm.nih.gov/40721661/ A great collaboration between the @FGH_Lab and @LabHuvr labs, driven by the outstanding work of @olmedo_pelayoJ at @ibis_sevilla Check it out!
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Fernando Gomez-Herreros Lab 리트윗함
Proud to announce that last Thursday I successfully defended my PhD thesis, “Understanding genome instability in Ewing sarcoma: from molecular mechanisms to novel therapeutic approaches”, at the @ibis_sevilla.
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Fernando Gomez-Herreros Lab 리트윗함
📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP
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Fernando Gomez-Herreros Lab 리트윗함
Thrilled to share our latest work. Great collab with Costanzo, Masson, Freire and Reyes' labs.
HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances science.org/doi/10.1126/sc…
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Fernando Gomez-Herreros Lab 리트윗함
Se ha filtrado el borrador de ley de universidades que está preparando la CAM. Si se aprueba, será la muerte de la universidad pública madrileña. Es escandaloso. No exagero. Se vienen tiempos oscuros como no espabilemos. Explico algunos puntos críticos. Va hilo. 👇
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Fernando Gomez-Herreros Lab 리트윗함
¡¡Premio Nacional de Juventud en Ciencia y Tecnología!! Gracias @InjuveSpain y @JuventudInfGob por dar visibilidad y reconocer la labor de los jóvenes investigadores en España. @ibis_sevilla @FISEVI_sevilla @FGH_Lab @InvestigaUS
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Happy to be awarded with a Consolidación investigadora grant to continue exploring ssDNA gap biology at @unisevilla and @cabimer. A postdoc position will be advertised soon. Stay tuned!
Agencia Estatal de Investigación@AgEInves
ℹ️ La @AgEInves publica la propuesta de resolución provisional de la convocatoria 2024 de ayudas para incentivar la consolidación investigadora. 🔗 aei.gob.es/sites/default/… 💰 41,9 M€ para consolidar la carrera de 221 investigadores/as en España.
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Fernando Gomez-Herreros Lab 리트윗함
Have a look at our review in @MolecularCell . We explore how histone modifications serve as integrators of genome activity, mediating communication between distinct DNA procesess. authors.elsevier.com/a/1kS2f3vVUPRn…
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Fernando Gomez-Herreros Lab 리트윗함
