Intestinal Cell News

From #organoids to intestinal cancers, #IntestinalCell News is dedicated to covering it all. Subscribe to the free newsletter and never miss another update! 📰 🔗 bit.ly/4kkWMEu

ADAT2-driven tRNA A-to-I modification promotes colorectal cancer tumorigenesis and chemoresistance via HDAC7-WNT/β-catenin axis. 🔗 bit.ly/40KMSUj

Multitasking is one of the most counter-productive habits you can have. @STEMCELLTech bit.ly/43LkEtH

Researchers at @ugent alongside Dr. Olivier De Wever show that targeting PI3K/mTOR or MAPK/ERK pathways reshapes CAF states in colorectal cancer. Read more here: 🔖 bit.ly/475oD6X

Researchers show that high protein S-palmitoylation in gastric cancer marks aggressive tumors with poorer survival, reveals immunosuppressive niches, and highlights an 87-gene risk signature and HSP90–PI3K/MAPK vulnerabilities. go.nature.com/4sL5tf1

Multitrait analysis of GWAS reveals a novel pleiotropic locus at 12q22 that is shared between gastric cancer and cardiovascular traits. Read more here: 📝 go.nature.com/4sRLmvG

Researchers integrated single-cell RNA sequencing (119,931 cells from 25 gastric tumors) with spatial transcriptomics and bulk cohorts to delineate palmitoylation-linked states across malignant, immune, and stromal compartments. 📕 go.nature.com/4sL5tf1

🔬 Researchers dissect the differentiation origins of intestinal metaplasia and early intestinal-type gastric cancer in gastric antrum by single-cell RNA profiling. go.nature.com/4cKiTDk

Researchers elucidate the mechanism by which ALYREF regulates the long non-coding RNA cancer susceptibility 19 through m5C modification and its impact on colorectal cancer malignancy. 🔎 bit.ly/3NrgxyK

Scientists find that L1TD1 promotes colorectal mucinous adenocarcinoma progression by enhancing ABCC3 mRNA stability. @oncogenejournal Discover more here: go.nature.com/3OT42MZ

Researchers identified phosphomannomutase 2 (PMM2) as a key oncogenic driver in colorectal cancer (CRC). They found that PMM2 was significantly upregulated in CRC tissues and cell lines. 🔗 go.nature.com/3OZbDtl

💡 Reshaping the colorectal cancer immune microenvironment! Scientists synthesize single-cell RNA sequencing and spatial transcriptomic studies of colorectal cancer to characterize cellular heterogeneity. 🔗 bit.ly/3OTnedp

🚨Become an expert on using #organoids in drug discovery with @STEMCELLTech! Stay up-to-date with current applications, new products, insights from key opinion leaders, and more: bit.ly/3QSfIwU

Researchers from the Yatrik Shah Lab demonstrate that glucose metabolism sustains aberrant STAT3 signaling in colorectal cancer. @UMich 📕 @scisignal 📝 bit.ly/3ONHGfO

Researchers find that TAAR1 inhibition alleviates colitis severity, intestinal inflammation, and barrier dysfunction. Discover more in this study: 🔎 bit.ly/4ubtJII

p53 and fatty acids collaborate to trigger ferroptosis! Researchers' findings reveal that p53 induces ferroptosis in the presence of abundant polyunsaturated fatty acids. 📝 bit.ly/3NaiOOI

A team of scientists at @PennMedicine alongside Dr. Klaus Kaestner highlight that the villification of the intestinal epithelium is driven by Foxl1 through activation of PDGFRα and BMPs. 🔎 go.nature.com/40tyxeK

In this study, researchers investigated the role of Claudin18.2 in gastric cancer progression and its potential clinical significance. @SciReports Learn more here: 🔗 go.nature.com/3OEKXOe

Scientists provide a comprehensive platform for understanding how genetic and epigenetic variants disrupt transcriptional programs in colorectal cancer. 📕 @ScienceAdvances 🔖 bit.ly/46XI7tX

Researchers find that a nuclear isoform of hydroxyacyl-COA dehydrogenase inhibits tumor progression in colorectal cancer. 📘 @iScience_CP 🔖 bit.ly/4rytpSl

Scientists summarize the current understanding of antigen transport across the intestinal epithelium in steady state and food-allergic conditions. Learn more here: 📖 bit.ly/4cJRelI