Joe Springer

Humans are extraordinarily sensitive to the smell of rain, known as petrichor, primarily due to the compound geosmin. We can detect geosmin at parts-per-trillion levels, whereas sharks typically detect blood in water at parts-per-million or parts-per-billion concentrations. This means humans are roughly 200,000 times more sensitive to the scent of rain than sharks are to blood. Such heightened sensitivity likely evolved because smelling rain helped early humans locate fresh water and fertile environments. What seems like a pleasant aroma today was once a crucial survival signal.

@ShiningScience Let's do it!!

All 8 billion of humans could fit inside a single 1-kilometer cube. 🧍‍♂️🧍‍♀️ It might sound unbelievable, but every person on Earth could physically fit inside a cube just 1 kilometer high, wide, and deep. That’s because the combined volume of all humans is less than half the volume of a cube measuring 1 km on each side. For context, the volume of all humans is 4.7×10^8 meters. While the volume of a cube that high is about 1×10^9 meters. Of course, this tightly packed cube wouldn’t be livable or humane, but it offers a powerful visual to grasp how small our physical footprint is compared to the size of the planet. Humanity, despite its massive impact on Earth’s ecosystems, takes up surprisingly little space in terms of sheer volume. While our presence shapes climate, landscapes, and biodiversity, our actual physical volume could fit comfortably within a city block-sized cube. It’s a humbling reminder of the scale of Earth—and how our influence is outsized not by body mass, but by choices and systems.

The Arc gene (Activity-regulated cytoskeleton-associated protein) and memory engram cell are both central to the neuroscience of learning and memory, and they are functionally linked. Arc isn’t just a plasticity gene—it forms virus-like capsids that transfer mRNA between engram cells, helps tag active synapses, and enables memory updating. Precise Arc levels are essential: too much or too little disrupts memory. Dysregulation is linked to Alzheimer’s, but targeted rescue shows promise. (Ashley, 2023; Chen, 2024; Kim, 2024)

Six Strong Trends For This Unknown Stock open.substack.com/pub/multibagge…

My notes: "Strategy explains how a company achieves sustainable value creation...Sustainable value creation is distinct from sustainable competitive advantage...Multiple companies in the same industry can achieve sustainable value creation...We place special emphasis on two of the forces: threat of new entrants and rivalry among existing firms....At a high level, barriers to entry are either structural or strategic. Structural advantages come from scale benefits that lead to lower costs, access to scarce resources, or regulation. Strategic barriers are the result of actions incumbents take to fend off or discourage entrance....The weapons of rivalry include pricing, service offerings, capacity changes, new products, advertising, and promotional spending....Cooperation tends to emerge when companies frequently interact with one another and therefore learn how to send and receive signals....Assets that companies cannot deploy elsewhere create a barrier to exit...Strategic positioning is about difference, and defines how a firm’s activities differ from those of the competition...The decomposition of financial results shows that while industry and management are relevant, strategy is the most important determinant of long-term value creation."

This Resource Is The Next Gold multibaggersvip.substack.com/p/this-resourc…

You'll be OK

@MattNachtrab Perspective couldn't figure this out for themselves? Why would you say such a thing?

@JoeSpringer Haha. No sir. Bought all before. But… these funds are investing other peoples money. They are not likely to buy into non-consensus MOA that has been accused of fraud prior to a pending p3 readout.

@MattNachtrab LOL Wait until the stock is 20X higher? Is that what you did?

How credible is this money manager friend? To me it makes sense for some to buy 25% position now and buy 75% on data. I am refining my expectations for mild, moderate and total ADL and Adas-cog12 so I can quickly assess the quality of the results. We have some recent phase 3 trial data from Lilly and Biib that I’m deep diving now.

@JoeSpringer “Hits” meaning good news

@swingtrader So sorry to hear There is an encouraging new drug with data reading out by the end of the year Drug is a major threat to the big players so the attacks on this little company are relentless Terrific stories coming out of the trial $SAVA x.com/mattnachtrab/s…

@jani_kiviniemi Martina.

@jani_kiviniemi That's her.

@GabrielDirienzo Put it on Mars?

@JoeSpringer Joe is there anyway we can get Musk to look at Sava

Targeting integrins is gaining traction in Alzheimer's and dementia Filamin A is a major gatekeeper to integrins In its native conformation, filamin A's integrin binding site is auto-inhibited Fix the conformation back to the native form --> stop integrin-induced Alzheimer's pathology $SAVA

More than two decades ago migfilin showed that binding filamin A in the same general place as simufilam is possible, and modulates cell shape $SAVA

Funny, you don't hear about the actin cytoskeleton hallmarks of Alzheimer's like cofilin and Hirano bodies I wonder if it is because BP has no treatments related to the actin cytoskeleton? Anyway, it seems properly shaped filamin A phosphorylates cofilin, deactivating it and preventing tauopathy $SAVA

$SAVA It's done!!

@JoshTradeOption Next up -- sleepier stocks!! Make sure we keep our winnings.

@JoeSpringer That’s great. I’m certainly ready to go. I appreciate all you do here. Who we got after SAVA?

Thank you again, Yale! Hot of the presses! Yale team already demonstrated simufilam's MOA and efficacy in mouse seizures. Now they show same MOA restores cortical synaptic connectivity. Ya know, like in Alzheimer's disease. $SAVA pubmed.ncbi.nlm.nih.gov/39164108/