John L.

#Stones turn #water into #music. ​#石 は #水 を #音楽 に変えます。

The importance of deep reading and critical thinking as our brains adapt to digital distractions and AI shortcuts is the subject of this year’s Princeton Pre-read book for the Class of 2030, “Reader, Come Home: The Reading Brain in a Digital World” by Maryanne Wolf: bit.ly/47OpXeP

Joost Boormans’ Excellent Summary of NMIBC and UTUC Updates from EAU26 - Sabine D. Brookman-May (@brookmans76) oncodaily.com/voices/471121 #Cancer #Oncology #OncoDaily #Health #Medicine #MedX #EAU26

Use of tranexamic acid reduced the risk of major bleeding in patients undergoing urologic surgery, results from the randomized POISE-3 trial showed. #EAU26 medpagetoday.com/meetingcoverag…

Time-of-day administration of ICI matters in metastatic #kidneycancer just presented at #EAU26 thanks to @YujiMiura5 @DrDanielHeng and other collaborators Results from an ongoing prospective trial are eagerly anticipated @BCCancer_Agency @Uroweb @OncoAlert urosource.uroweb.org/267359/abstract

Proud moment and HUGE news from #EAU26: #PRIMARY2 shows PSMA PET/CT can safely halve prostate biopsies in men with equivocal MRI, avoiding biopsy in 49% without missing cancer. uroweb.org/news/scan-that…

💶Cost ⏳Time 🏟️Social norms ❌Misinformation These are some of the factors that stand in the way of people living healthier lives & reducing their risk of #cancer. Learn more in a 🆕 #IARCpaper on the @cancercode, barriers, & facilitators #ECAC5. iarc.who.int/news-events/ne…

Great to be back from Nepal! In this week's first Substack article, we discuss a recent paper written with Chris Kempes on the role of energy in health and disease. The key difference between life and death is not the physical stuff of life. It's the flow of energy. We propose that thinking about health and disease processes energetically can unlock a meaningful transition to the next stage of evolution for biomedicine.

Paper from myself, Dr. Braunwald and others on the use of AI to guide shared decision making. We conduct trials and draw inferences from / about populations. We treat individual patients, however, who have innumerable combinations of subgroups with second and higher order interactions (which can be modeled with ML/AI). We see patients in clinic and iteratively reassess their risk moving forward based upon the presence or absence of events (including multiple events) & their tolerability of a drug / device (eg a patient who has not bled is at a lower risk of bleeding moving forward) We should also take into account individual patient preferences (not population preferences) with respect to ischemic / bleeding outcomes and side effects. We incorporate all of this into a new AI model. jacc.org/doi/10.1016/j.…

New paper: What determines AIs’ self-conception? theartificialself.ai Because AIs can be copied, rewound, and edited, they have different options for selfhood than humans. We show this is still malleable, and influences important behaviors such as self-preservation. 🧵

Millions live with chronic pain & little relief. #HannaGray Fellow @shanmeltzer & team's new map of the spinal cord — built cell-by-cell — provides insights into how pain-signals travel, & will be made openly available to help speed new pain treatments: hhmi.news/4u1eIsJ.

Convocation 2026: #UofT to confer honorary degrees on nine inspiring individuals #UofTGrad26 📜 uoft.me/hd26

"To understand the future, you can’t make prophecies—you have to understand the past," argues Frank Diana. time.com/article/2026/0…

"You have to focus on what you can do." Life advice from 2023 medicine laureate Katalin Karikó who is encouraging us all to focus on things that are within our control and pay less attention to what we can't control. For more life advice and to hear her life story, watch our full interview with her: youtu.be/X-jLB2cbdB8

Exciting new research reveals that phosphoenolpyruvate (PEP), a natural metabolite produced during glycolysis, acts as a key defender against chronic #inflammation during aging. Scientists discovered that PEP levels rise in the body during early #aging as a protective response, directly inhibiting the cGAS-STING pathway - a central driver of age-related inflammation and disease. This "self-protective" mechanism is evolutionarily conserved in both mice and humans, but as advanced aging progresses, PEP levels decline, leading to exacerbated inflammation and functional decline. The findings offer promising therapeutic potential: supplementing PEP in aged mice successfully reduced inflammation, improved cognitive function, extended healthspan, and even alleviated #Alzheimer's disease pathology. In humans, higher PEP levels in older adults strongly correlated with better kidney and liver function and lower inflammatory markers. This positions PEP as a compelling candidate for interventions aimed at promoting healthy aging and combating age-related diseases. nature.com/articles/s4358…

A guide to remembering everything you read: bit.ly/4rxUHIr v/@CuriousMindsHub

Health is where AI faces its hardest test: layers of regulation, life-or-death stakes, complex biology, and a deeply human, compassionate core that most people would assume is the last thing a machine could replicate, William Warr writes for TIME. time.com/7382493/ai-hea…

New research published in Nature Communications uncovers DNA “tagging” changes in the brains of people with #Alzheimers — many linked to the tau protein. The findings may help explain why the disease progresses differently from person to person. Learn more: mayocl.in/4b3pqqb

Injectable “satellite livers” built from hepatocytes and hydrogel microspheres restored liver functions for at least 8 weeks in mice, hinting at a future alternative to liver transplantation. doi.org/hbrbbz medicalxpress.com/news/2026-03-s…

FDA authorizes resumption of Intellia’s heart‑disease gene therapy trial after a safety pause. Last year, the FDA paused Intellia's two trials of the ​gene-editing treatment after a patient in the heart disease study was ​hospitalized with severe liver complications and later died. Monday's decision allows for resumption for the trial in cardiomyopathy patients. reuters.com/business/healt…

🚨: These Hydrogen atom shapes reveal where electrons are most likely found through their quantum wave functions! BREATHTAKING!