Sabine D. Brookman-May

Discussion on patient selection for radioligand therapy in #ProstateCancer. Oliver Sartor, MD @EJHospital and @DanielPetrylak @YaleCancer, join @neerajaiims @huntsmancancer the art and science of selecting patients for PSMA radioligand therapy in #mCRPC. They discuss using PSMA PET SUVmean, genomics, disease sites (strong for nodes/bone, weak for liver), and clinical factors like hemoglobin and renal function—underscoring that lesions with uptake below liver should generally not get RLT and that earlier, individualized treatment yields better outcomes. #WatchNow > bit.ly/3ZAzEJ6

So important to get the right treatments developed for upper tract disease #UTUC Looking forward to seeing more trials in this indication as we need an organ sparing approach here #Dabogratinib might offer a great option to treat these patients given the high rate of #FGFR3 alterations in UTUC + the improved safety profile compared to unselective FGFRinhibitors #UTUC #FGFR3 @oncodaily #SURF303 @TyraBiosciences #UrothelialCarcinoma

Joost Boormans’ Excellent Summary of NMIBC and UTUC Updates from EAU26 - Sabine D. Brookman-May (@brookmans76) oncodaily.com/voices/471121 #Cancer #Oncology #OncoDaily #Health #Medicine #MedX #EAU26

Great project and publication @LawenTarek ➡️ leading to several subsequent questions on the potential causal relationship between low testosterone and GG3 progression in men with #ProstateCancer on #ActiveSurveillance What are the underlying hypothesis? ❓selection of androgen-insensitive/less-dependent clones? ❓association of low T with other causative factors such as metabolic syndrome, obesity, inflammation? ❓no causal relationship but association with reduced #PhysicalActivity, frailty, age, less immune-surveillance? Would be great to see more data on this topic and specific assessments of biomarkers, longitudinal T, molecular status overall, lifestyle factors #ProstateCancer #ActiveSurveillance #Testosterone @oncodaily @JUrology @urotoday

Evaluation of urinary minimal residual disease and outcomes in high-risk #NMIBC surveilled with blue light compared to white light cystoscopy. Presentation by Meghan McNamara, MD @brady_urology. #EAU26 written coverage by @zklaassen_md @GACancerCenter > bit.ly/4bMf0ww @Uroweb

After our session at #EAU26 I met with Jeremy Bellaiche from shuf.ai to integrate the main messages on physical exercise and cognitive performance in a short #podcast. Very nice experience to start with and hope to work together on more topics in the future! Great tool for MDs to generate informative and individualized podcasts @jeremy02766919 shuf.ai #PhysicalExercise #CognitiveFunction #Exercisumab #BrainFertilizer @uroweb 👉shuf.ai/episode-player…

Diagnostics in #UTUC are evolving and we see some practice-relevant signals👇 #EAU26 ☑️PET-CT improves staging of high-risk UTUC → ~18% of patients were upstaged vs CT → ~17% treatment escalation ☑️Urine DNA methylation markers may help replace diagnostic ureteroscopy in selected cases → AUC ≈ 0.97 #UTUC #BladderCancer #Urology @uroweb @oncodaily @urotoday 👉👉urosource.uroweb.org/resource-centr…

Excellent summary on #NMIBC and #UTUC treatment, diagnostics and biomarkers from #EAU26 by Joost Boormans 👉urosource.uroweb.org/resource-centr… Key takeaways on #NMIBC and #utDNA/urine biomarkers 👇 ☑️#Erdafitinib-iDRS shows strong activity as ablative treatment in FGFR-altered IR-NMIBC → 6-month CR rate: 89% + as adjuvant treatment in BCG-treated HR-NMIBC, adjuvant erdafitinib shows → 1-year RFS: 83% ☑️#utDNA highly prognostic → patients #MRD-negative at baseline and week 12 had ~100% 1-yr RFS #THOR2 ☑️For HR-NMIBC, strategies that may shape future care are optimized intravesical therapy (e.g. BCG + MMC) + biomarker-guided surveillance ➡️opens promising perspectives for biomarker-guided follow-up and treatment decisions #NMIBC #BladderCancer #UroOnc @oncodaily @Uroweb @urotoday

First-in-human Nectin4-targeted fluorescence imaging for TURBT #EAU26 @urotoday • Diagnostic accuracy: 96% vs 85.6% with WLC • Tumor margin detection: 91.1% vs 72.2% • Ex vivo biopsy accuracy: 96.3% • Preclinical models doubled complete resection rates Probe demonstrated a favorable safety profile

Young urologists are not just the future of our field—they are shaping it today. The Young Academics of Urology works to strengthen the scientific foundation, research skills, and international collaboration of the next generation of urologists. #Urology #YAU #EAU26

Finishing #EAU26 with a great @uroweb Friendship Dinner #Urology @spsutkaMD @carme_mir1 @NNHarke @Yasminabugh

Congratulations to superstar @shilpaonc on receiving the ‘Medical Oncologist Ambassador Award’ for all her work in supporting bladder cancer efforts at @EUplatinum @EurUrolOncol 🥇⭐️👏 #EAU26 @IBCG_BladderCA @ClevelandClinic

@brookmans76 Wonderfully fun/insightful session Insights from amazing colleagues on sustainability of a surgical career - understand & honor CORE VALUES, create structure in life - make time for physical/mental health (sleep well) - understand that ADVERSE EVENTS will affect you, be prepared

Monique Roobol #eau26 wonderful update on PRAISE-U; RCT vs real world implementation of #prostatecancer screening across the EU @Uroweb

After a short exercise session this morning, I was very honored to join a great panel on the topic of physician‘s wellbeing and sustainable performance at #EAU26 and talk about the significant positive impact of physical exercise on #cognitive function and resilience - beyond all well known impact on life span, health span, cancer and chronic diseases #PhysicalExercise #BrainFertilizer #Exercisumab @Uroweb @UroDoco @drphil_urology @carme_mir1 @JLVasquez82 #JasonHowlett @urotoday

Great to be @EUplatinum Platinum Circle Reviewer 🥂@Uroweb #EAU26

Advancing Precision in Muscle-Invasive Bladder Cancer: The Critical Role of Histologic Subtyping #ASCODailyNews @ASCO #OncSurgery @UTMDAnderson @SagarRPatelMD @TarynAEllis @JosephBBlack dailynews.ascopubs.org/do/advancing-p… #EAU26

@SimonMDLord @alison_tree @TylerSbrt @scserendipity1 @aadel_chaudhuri @cwspeers @andreasroder1 @ResearchWyatt @shiv_smith @RenuEapen @AlisonBirtle @mrsprostate @MariamAboian @sophia_kamran @lauren_henke @HimanshuNagarMD @JuanMiguelPechL @swoo_rad @Prof_Nick_James @dr_coops @mleapman @mwschoen @matthew_hobbs @AdamSharpMedOnc @DrRanaMcKay @ASCO No water here right now, but great cycling weather ☀️🚴‍♂️

@alison_tree @TylerSbrt @scserendipity1 @aadel_chaudhuri @cwspeers @andreasroder1 @brookmans76 @ResearchWyatt @shiv_smith @RenuEapen @AlisonBirtle @mrsprostate @MariamAboian @sophia_kamran @lauren_henke @HimanshuNagarMD @JuanMiguelPechL @swoo_rad @Prof_Nick_James @dr_coops @mleapman @mwschoen @matthew_hobbs @AdamSharpMedOnc @DrRanaMcKay @ASCO Water in Malta last week. Now back to the grindstone.

🏃🏼 by 💧 Any recent 🚶🏻‍♀️🏃🏽‍♀️🚴🏼 photos from my oncology friends around the 🌍 ? @VedangMurthy @aadel_chaudhuri @cwspeers @andreasroder1 @HenningWillers @brookmans76 @_ShankarSiva @ResearchWyatt @ProfAJChalmers @shiv_smith @scserendipity1 @SimonMDLord @RenuEapen @AlisonBirtle