Riccardo Percudani 🐳

Over a century after Garrod's pentosuria, we found how L‑xylulose is formed in the pentose pathway via coevolutionary analysis of KEGG networks. A long-standing metabolic gap bridged in @PNASNews. #Bioinformatics #Genomics #Biochemistry #Metabolism pnas.org/doi/10.1073/pn…

Research highlight @Percud: Urate metabolism, in the gut academic.oup.com/lifemeta/artic…

A novel component of the CatSper ion channel (Armh2) uncovered! Great collaboration with @JeanJuChung and @jianpingwu8 nature.com/articles/s4146…

Great new machine learning study from @unipr researchers: Read it here 👉 doi.org/10.1007/s10994…

Michael Galperin @MicroGap is a wizard. How did he know?

Using bioinformatics for identifying and plugging metabolic pathway holes | PNAS pnas.org/doi/10.1073/pn…

Deep-learning-based single-domain and multidomain protein structure prediction with D-I-TASSER go.nature.com/4kwCaIK

Predicting Protein Function in the AI and Big Data Era | Biochemistry pubs.acs.org/doi/10.1021/ac…

EvoWeaver provides as output its 12 predictions for signals of coevolution, and can optionally provide an ensemble prediction using built-in pretrained models. Functional associations often result in correlated gain/loss patterns on a reference phylogenetic tree.

"It's not a goal that is the goal, it's actually the path towards the goal." 2014 chemistry laureate Stefan Hell shares his best career advice for young scientists and researchers. #NobelPrize

Will soon open a position in my group in Padova. Topic is mechanistic enzymology with cool serial X-ray, electron and neutron crystallography work... plenty of opportunities for collaborations with leading groups. Get in touch with me roberto.steiner@unipd.it if interested.

Pierre-Régis Burgel presenting the keynote speech at the 22nd convention of investigators in Cystic Fibrosis.

Mitochondria never cease to amaze

@ditlevbrodersen the diet of your ancestors wasn't so bad after all!

And the #localBLAST is better

Our #bioinformatics course assistants love using ChatGPT visuals in the computer lab exercises. I found this #BLAST visual quite punching!

@stevenstrogatz d6xf4

From a blitz game I played today while walking my dog. What's the best move for Black? (For the rest of the sloppy game, see: #49" target="_blank" rel="nofollow noopener">lichess.org/r07LQOf5/black…)

This year’s medicine laureates Victor Ambros and Gary Ruvkun studied a relatively unassuming 1 mm long roundworm, C. elegans. Despite its small size, C. elegans possesses many specialised cell types such as nerve and muscle cells also found in larger, more complex animals, making it a useful model for investigating how tissues develop and mature in multicellular organisms. Read how the 2024 medicine laureates’ investigations into C. elegans revealed an entirely new dimension to gene regulation: bit.ly/4dlPE6f #NobelPrize

Link: blog.atomsonly.com/p/estimating-t… Also, I previously tweeted about this story, so you may have already heard about it. x.com/NikoMcCarty/st…

High-resolution cryoEM structure of UapA, the original member of the NAT transporter. While UapA transports uric acid, other members of this family transport ascorbate. Linus Pauling proposed an evolutionary connection between uric acid and ascorbate (vitamin C)