Sandy Richardson

🐭🧬Our paper on locus-specific mouse L1 activity and regulation, led by the indomitable @Patricia_Grds is out @genomeresearch!🧬🐭 This study evolved from a simple question: what defines the mutagenic potential of a new L1 copy in vivo? genome.cshlp.org/cgi/content/lo… A thread: 1/n

Renee will represent @materresearch, @UQmedicine, and #mobileDNA enthusiasts everywhere at the University final later this year! #scicomm #3MT

Congratulations to multi-talented PhD student Renee Chu, who won the overall competition AND People’s Choice at the @UQmedicine 3MT final, using a thoughtful analogy to describe her research on jumping genes in early development 🧬🧫

The impact of LINE-1 retrotransposons on neurobiology is not fully understood. Our new research in @NatureNeuro sheds light on LINE-1 activity in PV interneurons, sparking fresh perspectives on its role in neurobiology. #neuronaldiversity #neurogenetics nature.com/articles/s4159…

The Andalusian Government (south Spain) has opened a call for 3-year postdoctoral positions. If you would like to join my lab at the @ipbln_csic in Granada to investigate the regulation and impact of human mobile DNA, please contact me with an EOI. See more details below.

@StephWorkman3 and I had the privilege of writing a Preview article highlighting recent work by @retrogenomics and @sophie_lanciano on locus-resolution human L1 epigenetic analysis in @CellGenomics. Congrats to Gael, Sophie, and the whole team on their excellent study.

@retrogenomics @CellGenomics Thank you Gael! It was an honour to write about your beautiful work.

@CellGenomics This nicely written preview on our work by @RichardsonL1Lab and Stephanie Workman is also worth reading ! cell.com/cell-genomics/… @CellGenomics #transposon #LINE1 #epigenetics #TE #MobileDNA

Locus-level L1 DNA methylation profiling reveals the epigenetic and transcriptional interplay between L1s and their integration sites dlvr.it/T2nkWJ

Interested in L1 retrotransposon regulation in development? Check out AEpiA member @RichardsonL1Lab's recent paper in @genomeresearch "Locus-resolution analysis of L1 regulation and retrotransposition potential in mouse embryonic development" genome.cshlp.org/content/early/…

Illuminating talk by @RichardsonL1Lab Transcriptional regulation of Heritable activity of L1 activity in preimplantation embryonic development Work of @Patricia_Grds from @Faulkner_Lab group #EMBOMobileGenome

This study represents a huge amount of work by @Patricia_Grds, @Faulkner_Lab, and the most wonderful group of co-authors you could ask for: @Dory_genome, @MischaLundberg, @FranciscoJSL2, @gabriela_bodea, @_adamewing. 💗 and gratitude to all involved! 20/20

Together, our results suggest an interplay between L1 transcription initiation and de novo DNA methylation during differentiation in the early embryo, potentially involving YY1 or its binding sites within the L1 5’UTR. Excited to gain mechanistic insight into this process! 19/n

🐭🧬Our paper on locus-specific mouse L1 activity and regulation, led by the indomitable @Patricia_Grds is out @genomeresearch!🧬🐭 This study evolved from a simple question: what defines the mutagenic potential of a new L1 copy in vivo? genome.cshlp.org/cgi/content/lo… A thread: 1/n