Sandro Bottaro

Proud to share our latest work led by X-less Oliver Dutton! We've demonstrated that inverse folding models can be substantially improved at protein stability prediction without additional training or data. 1/4

New preprint with @inve_michele, @SSadnro, @KamilTamiola, and @LindorffLarsen on atomistic simulations of disordered proteins, using enhanced sampling to uncover some order within disorder. biorxiv.org/content/10.648…

Sampling IDPs is tough, but can be worth the effort! OPES multithermal made it a little easier for us, hopefully you'll find it useful as well @PeptoneLtd

Transient tertiary structure in intrinsically disordered proteins revealed by multithermal enhanced sampling biorxiv.org/content/10.648… #biorxiv_biophys

Walking around Naples in a Juventus shirt…. With Maradona on the back 😂

@valeriolundini Ho sentito che vi siete sciolti e hai formato i vanzazzaroni

Ciao! Mi piacerebbe ricordarvi che la simpatica band musicale dei VazzaNikki suonerà DOMENICA 13 LUGLIO a ROMA (Testaccio Estate, ore 21), il 16 LUGLIO a BOLLATE - MILANO (Villa Arconati, ore 21) e il 20 LUGLIO ad ANDRIA (Festival della Disperazione). Commentate se non ci sarete!

@emastokholma Sono cefalopodi molto intelligenti. Mi hanno sempre sorpreso quasi quanto i ciclisti in volata

Il mondo dei polpi

@Ryanair_IT @vonderleyen Ciao @Ryanair_IT potresti ascoltare anche me? ho bisogno di supporto per mio padre disabile e dializzato, in attesa da due mesi di un vostro riscontro

Francia in sciopero, voli a terra, vacanze rovinate. L’UE? Ancora in modalità “aereo” ✈️📴 @vonderleyen è ora di farci ascoltare

@hkanji Octopuses are incredible youtube.com/watch?v=mFP_Aj…

A comprehensive review by the London School of Economics concluded that octopuses are capable of experiencing pleasure and pain sustainability-times.com/impact/this-sh…

@Ryanair @Ryanair_IT Still no word from @Ryanair_IT @Ryanair but at least the scammers are showing real interest in my case. Nice to know someone cares

Hey @Ryanair @Ryanair_IT two months trying to get assistance for my dad disabled & on dialysis. Radio silence. We’re not asking for VIP perks, just basic human support.

@Ryanair is this account legit?

Maybe @Google or @GoogleDeepMind should fund CASP, given their ample resources and how much they've benefited from the efforts of John Moult, Krzysztof Fidelis, Andriy Kryshtafovych, Nick Grishin, and many others. science.org/content/articl…

@BonomiMax @HamidR_Ghafouri @SchnapkaV @biorxivpreprint @ERC_Research Great work - congrats @SchnapkaV !

🚀 Super excited to share our new work, led by @SchnapkaV 🚀 bAIes, a Bayesian framework for generating accurate atomic-resolution ensembles of disordered & multi-domain proteins using #AlphaFold info! Now on @biorxivpreprint @ERC_Research biorxiv.org/content/10.110…

Please RT! I have 2 postdoctoral positions in my lab @BRFAA_IIBEAA to work on MD sims for protein allostery, cryptic pocket identification, CADD/FEP. Knowledge in coarse-grained MD is a plus. More info: linkedin.com/hiring/jobs/42…. Send me an email with your CV if interested!

Un caro ringraziamento a @SEA_Press per averci abbandonato sulla pista di Malpensa alle due di mattino

🚨 Program Update: CADD GRS 2025! We're excited to welcome @wpwalters as our keynote: "AI in Drug Discovery – Revolution, Evolution, or Complete Nonsense?" A perfect kickoff for an inspiring weekend in Portland! 🔗 grc.org/computer-aided… #CADDGRS2025 #compchem #DrugDesign

Just published in @NatureComms our new paper integrating #MD and #cryoEM data to construct structural ensembles of complex #RNA macromolecules 🎉✨🥳nature.com/articles/s4146…. Excellent work by @ElisaPos with @BussiGio @BonomiMax @PJanosJr N. Toor, D. Haack

Il barolo ce lo terremo per noi youtu.be/aaZZxHiidNk?fe…

@ComuneSDM purtroppo il parco del laghetto è pieno di vetri e sporcizia. È possibile mandare qualcuno a pulire?

🚀 New preprint alert! 🚀 Introducing Loxodynamics, a simple yet powerful deep learning method for exploring chemistry and catalysis by biasing skewed distributions. Check it out! 🔬⚡ #MachineLearning #Catalysis #Chemistry chemrxiv.org/engage/chemrxi…