Science Translational Medicine

Studies of uterus transplant recipients reveal how immune cells shape pregnancy outcomes, an amino acid cocktail enhances nanoparticle delivery of therapeutic mRNAs in mice, and more this week in #ScienceTranslationalMedicine. scim.ag/3NgmFcX

Traumatic head injuries from collision and combat sports disrupt the #BloodBrainBarrier and trigger inflammation for years after retirement, shows an MRI and transcriptomic analysis of retired athletes. @mattcampbelltcd @gastaut @Fro_Greene @tcdgenmicro scim.ag/4bx1iwh

Head trauma from sports can disrupt the blood-brain barrier for years in retired athletes, a highly toxic mutant protein could offer a more effective target in Huntington's disease, and more this week in #ScienceTranslationalMedicine. scim.ag/4lAsui7

Researchers present one of the largest analyses of dual-positive #CTCs in patients, tracing how these cells correlate with outcomes in advanced #BreastCancer and how they seed metastasis in mice. @CtcLaboratory @ReduzziCarol @WeillCornell scim.ag/4sbdKsL

Amino acid supplementation enhances the uptake of lipid nanoparticles carrying #mRNA therapies in vitro and in mice, suggesting this simple approach could overcome delivery efficacy roadblocks in mRNA #GeneTherapy. @biohub @ShanaOKelley @KelleyLabs scim.ag/46UbBch

A team presents vaccines for H5 clade #influenza based on a stabilized H5 hemagglutinin stem, which improves the breadth and depth of antibody responses and protects against #H5N1 challenge in immunized mice. @KingLabIPD @anniedosey @UWBiochemistry scim.ag/4reeKei

New research reveals that uterine-resident #NaturalKillerCells decline in the endometrium of recipients of uterus transplant due to NFAT inhibition after tacrolimus, and links these disruptions to pregnancy complications such as preeclampsia. @UABHeersink scim.ag/4rriIAo

Thrilled to share our new study in Science Translational Medicine: a simple amino acid “cocktail” dramatically boosts LNP delivery efficacy in a liver inflammation model. 🧪📈 Built in the @biohub ecosystem and directly advancing our grand challenge to decode inflammation. 🔥

How does the uterine immune system recover after transplant? A team studies uterine transplant and #HSCT recipients and shows that all immune cell lineages reconstitute despite a drop in #NFAT signaling. @nkbjorkstrom @BenediktStrunz @karolinskainst scim.ag/46TohA9

A noninvasive test can detect liver #cirrhosis and other non-cancerous disorders in multiple cohorts by searching for cell-free DNA markers in the #fragmentome, laying the road for a flexible, multidisease #LiquidBiopsy. @av_annapragada @KimmelCancerCtr scim.ag/40b6eBK

An isoform-switching therapy for #RettSyndrome uses alternative splicing to bias the production of the e1 isoform of MECP2, leading to partial correction of disease phenotypes in patient-derived neurons and boosting MECP2 production in mice. @bcmgenetics scim.ag/4aPtCuI

Leveraging systems #immunology, researchers characterize the distinct immunological profiles produced by #RSV and #SARSCoV2 infections in infants, providing data that explain clinical divergences and could inform future therapeutics. @jacksonlab scim.ag/4kS7ras

A team presents new vaccines for H5 clade #influenza based on a stabilized H5 hemagglutinin stem, which improves the breadth and depth of antibody responses and protects against #H5N1 challenge in immunized mice. @KingLabIPD @anniedosey @UWBiochemistry scim.ag/4reeKei

We've used a blood test—cell free DNA—for detecting cancer or prenatal fetal abnormalities. It turns out it can be used to detect liver diseases and all-cause mortality from other conditions @ScienceTM science.org/doi/10.1126/sc…

A noninvasive test can detect liver #cirrhosis and other non-cancerous disorders in multiple cohorts by searching for cell-free DNA markers in the #fragmentome, laying the road for a flexible, multidisease #LiquidBiopsy. @av_annapragada @KimmelCancerCtr scim.ag/40b6eBK

A noninvasive "fragmentome" test expands liquid biopsy to liver cirrhosis and other conditions, stabilized flu immunogens could improve vaccine efficacy for H5 influenza, and more this week in #ScienceTranslationalMedicine. scim.ag/4r3Jxdx

Leveraging systems #immunology, researchers characterize the distinct immunological profiles produced by #RSV and #SARSCoV2 infections in infants, providing data that explain clinical divergences and could inform future therapeutics. @jacksonlab scim.ag/4kS7ras

Researchers in this issue uncover a new epigenetic vulnerability in #AML, showing that inhibiting KDM4 histone demethylases can indirectly reactivate the tumor suppressor gene ZBTB7A and suppress AML in patient-derived models. @jacksonlab scim.ag/4aAUU80

By isolating immune cells from pediatricians, researchers employ rational design to engineer cocktails of monoclonal antibodies that neutralize #RSV and #metapneumovirus in rodents without generating resistance. @CQMU1956 scim.ag/4tFCwlO

New work deciphers how disruptions to #lymphatic drainage drive fibrosis in transplanted lungs and hearts through the accumulation of hyaluronan—and identifies potential therapeutic targets to prevent lung fibrosis in mice. @haileymshepherd @WashUSurgery scim.ag/4r2nrsb