PostX #UniteToFight2024

Analyse eines Betroffenen: ME/CFS und die Erfahrungen mit Ärzten und Gesundheitssystem - Erkrankungen & Therapie derstandard.at/story/30000003…

@AnilvanderZee @einfachkaffee @NinurtaDoc 14 subjects completed exercise training, they were older (53.5 y ± 11.6), primarily male (57%), obese (BMI 32.5 ± 8.4). Primary symptoms: brain fog (100%), fatigue (86%), post exertional malaise (57%)… I wonder how they screened for PEM… @sunsopeningband

@NinurtaDoc @einfachkaffee We see post‑exertional worsening of symptoms in different diseases, that doesn’t automatically make it PEM. I’m afraid that these researchers also didn’t have a clear understanding of PEM. At least, the study didn’t specify it, which is not a good sign. nature.com/articles/s4159…

I highly doubt they actually correctly classified PEM. Or its severity. I think no one doubts that as long as you don’t trigger PEM, any exertion can be beneficial. Thing is, for all but the mildest of cases, „normal levels of activity“ will trigger PEM.

@DavidJoffe64 @JudyandHuahua „Psychological stress“ „Retrospective“ „Mouse Modell“ I don’t think so. Let’s treat patients not psychopathologize them. The latter could also be „stressful“.

This is really interesting 🙏🏻🙏🏻 MCAS may also need to be considered 🧐

@therealRYC And if we compare side effects? Long term risks?

🚨 THE BIGGEST NEGATIVE RESULT IN PSYCHIATRY Psychedelics look like miracle cures for depression when compared to placebos. But a new meta-analysis asks: what if we compare them to open-label antidepressants? The massive psychedelic advantage vanishes 🧵

@Yash25571056 „Psychological stress“

"Psychological stress is a well-established exacerbating factor for atopic dermatitis (AD).. we conducted a retrospective analysis of AD patients and studied stress-challenged murine AD models.. Our analysis revealed a specific association between stress-induced eosinophilia and skin inflammation severity in AD patients.. In mice, genetic ablation of eosinophils conferred protection against stress-exacerbated dermatitis.. peripheral sympathetic nerves, rather than the hypothalamus-pituitary-adrenal axis, mediates the stress-induced worsening of skin inflammation.. skin-innervating Pdyn+ sympathetic neurons, but not their Npy+ counterparts, were both necessary and sufficient for driving stress-induced dermatitis and eosinophilia. [In conclusion,] psychological stress exacerbates AD(atopic dermatitis)-like inflammation through a specialized subset of skin-innervating Pdyn+ noradrenergic sympathetic neurons.." Relax for your skin. 'A sympathetic-eosinophil axis orchestrates psychological stress to exacerbate skin inflammation’ science.org/doi/10.1126/sc…

@BMG_Bund @ninawarken @ChariteBerlin @CarrollJennifer Die neue Leitlinie Endometriose baut das BPSM so stark ein, dass jede Frau von Beginn an eine F-Diagnose bekommt & von dort an psychopathologisiert wird. Risikofaktor für Schmerzchronifizierung u.a. Rentenbegehren.

„Endometriose wird in Deutschland inzwischen mehr als doppelt so häufig diagnostiziert wie noch vor zwanzig Jahren. Das ist eine gute Nachricht“, so @ninawarken bei ihrem Besuch des Endometriosezentrums der @ChariteBerlin mit ihrer irischen Amtskollegin @CarrollJennifer.

Gene set enrichment analyses indicated activation of circadian and translational programs and suppression of olfactory receptor, neurotransmitter receptor, and GABA-gated ion-channel pathways. Functional assays validated reduced NK-cell inflammatory capacity in LTCS participants.

This study provides in vivo evidence of white matter neuroinflammation in ME/CFS, characterised by cerebral edema, cellular infiltration and axonal reorganisation. This suggests NII-derived indices may serve as sensitive biomarkers for neuroinflammation in ME/CFS.

Neuroinflammation der weißen Substanz bei ME/CFS Diese neue Studie liefert mithilfe moderner Diffusionsbildgebung (Neuroinflammation Imaging, NII) die bislang wohl klarsten bildgebenden Belege dafür, dass ME/CFS mit entzündlichen Veränderungen der weißen Hirnsubstanz einhergeht.

@MetroUK Surgical masks won’t do the job

Woman from London ‘potentially developing symptoms’ after Kent meningitis outbreak trib.al/jlxA9BQ

LMU Munich, 83 children and teens, Long COVID was linked to fewer tiny blood vessels and stiffer arteries. Kids with shortness of breath showed the clearest vessel loss, suggesting symptoms may partly stem from impaired circulation. link.springer.com/article/10.100…

Das Kantonale Laboratorium Basel-Stadt hat bei einer Untersuchung gefangener Tigermücken erstmals das Dengue-Virus nachgewiesen. Dies stellt den ersten publizierten Nachweis dieses Virus in Stechmücken nördlich der Alpen dar, wie das Kantonslabor mitteilt. srf.ch/news/schweiz/u…

Advanced brain imaging shows widespread white-matter neuroinflammation in ME/CFS, with tissue swelling, immune cell infiltration & nerve fiber reorganization across key brain pathways correlated with greater disability, even when standard MRIs look normal. onlinelibrary.wiley.com/doi/full/10.10…

@ChrZacharias @martinruecker Wir denken alle an ihn 💙

@martinruecker Christian ist gerührt von dem Beistand, den er überall erfährt!

Wünsche @ChrZacharias, den ich zwar nicht persönlich, aber seit Jahren durch den Austausch auf Twitter/X kenne, von 💙 das Allerbeste - dass Sie die kompetente Hilfe erhalten, die Sie benötigen, und schnell eine maßgebliche Besserung erfahren!

@martinruecker @ChrZacharias Das hoffen wir alle. Sehr erschütternd und bedrückend.

Two young people have died and 11 others are seriously ill in hospital after an outbreak of invasive meningococcal meningitis in Kent, England. The two who died have been confirmed as a student at the University of Kent and a sixth form pupil bmj.com/content/392/bm…

New data from Wick et al. in Sci Rep: Post-COVID patients with EBV reactivation who received valaciclovir + anti-thrombotics saw nearly DOUBLE the functional improvement (Bell Score +43 vs +23) and 2x the self-reported recovery vs anti-thrombotics alone pubmed.ncbi.nlm.nih.gov/41796205/

Rio de Janeiro 75 patients with long COVID showed early signs of kidney tubule injury even when standard kidney function looked normal, suggesting urine biomarkers may catch hidden damage months before clearer decline appears. mdpi.com/1422-0067/27/5…

The association between hair cortisol levels, Epstein-Barr virus infections and chronic fatigue in adolescents tandfonline.com/doi/abs/10.108… A biopsychosocial theory turns out not to be true Screenshot from Science for ME weekly update #MEcfs #CFS

🚨 Older fathers are passing on far more harmful genetic mutations than we thought. It significantly raises the risks of autism and cancer in offspring, new research shows. New research shows that older men are far more likely to pass on disease-causing mutations to their children, due to a phenomenon known as “selfish” sperm. A large-scale study using cutting-edge genome sequencing revealed that while around 1 in 50 sperm from men in their early 30s carries a harmful mutation, that figure climbs to nearly 1 in 20 by age 70. These mutations arise not just from aging but from specific mutations that give sperm-producing stem cells a growth advantage—causing them to multiply faster and dominate sperm production over time. These “selfish” mutations disproportionately affect critical genes involved in neurodevelopment and cancer risk, and their exponential increase means that the danger grows more steeply with age. Researchers identified over 40 genes that can cause this effect, including those linked to autism and severe developmental disorders. Interestingly, while unhealthy habits like smoking and drinking did increase mutation loads in blood, sperm cells seemed largely protected from these environmental factors. This groundbreaking study reshapes how we understand paternal age and genetic risk—emphasizing that a father’s age is just as crucial as a mother’s in determining the long-term health of future children.

Today is #LongCovidAwarenessDay. I have been ill with #LongCovid for 6 years now. My life is unrecognisable from what it was. Still no treatments, hardly any research and very little support. We will never shut up about this until that changes.