Thomas Cardaci

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Thomas Cardaci

Thomas Cardaci

@TomCardaci

Research Fellow, Postdoc | PhD, MS, CSCS*D | Cancer, Muscle Biology, & Exercise | Colorado State University | CU Anschutz SOM | USC SOM, Rutgers & Baylor Alumni

Fort Collins, CO 가입일 Temmuz 2013
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Thomas Cardaci
Thomas Cardaci@TomCardaci·
Decellularized some muscle for SEM analysis of the extracellular matrix. I think it came out pretty sick!! #myotwitter
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South Carolina, USA 🇺🇸 English
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Thomas Cardaci
Thomas Cardaci@TomCardaci·
7️⃣ 🧩 Take-home: Muscle fibrosis is not a consequence of tumor presence but a distinct pathological feature of cancer cachexia. Cachexia promotes a profibrotic microenvironment, where immune cells + FAPs contribute to ECM remodeling and worsen muscle dysfunction beyond atrophy.
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Thomas Cardaci
Thomas Cardaci@TomCardaci·
6️⃣ Gene expression analysis further supports this profibrotic and altered immune microenvironment: ⬆️ TGF-β, HIF-1α, IL-6, Nos2 ⬆️ Collagens (Col1, Col5), Fn1, MMP2 ➡️ Cachectic muscle = active fibrogenic + inflammatory signaling.
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