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Decellularized some muscle for SEM analysis of the extracellular matrix.
I think it came out pretty sick!!
#myotwitter
South Carolina, USA 🇺🇸 English
Thomas Cardaci
739 posts
Thomas Cardaci
@TomCardaci
Research Fellow, Postdoc | PhD, MS, CSCS*D | Cancer, Muscle Biology, & Exercise | Colorado State University | CU Anschutz SOM | USC SOM, Rutgers & Baylor Alumni
Fort Collins, CO Katılım Temmuz 2013
753 Takip Edilen579 Takipçiler
7️⃣
🧩 Take-home:
Muscle fibrosis is not a consequence of tumor presence but a distinct pathological feature of cancer cachexia.
Cachexia promotes a profibrotic microenvironment, where immune cells + FAPs contribute to ECM remodeling and worsen muscle dysfunction beyond atrophy.
English
6️⃣
Gene expression analysis further supports this profibrotic and altered immune microenvironment:
⬆️ TGF-β, HIF-1α, IL-6, Nos2
⬆️ Collagens (Col1, Col5), Fn1, MMP2
➡️ Cachectic muscle = active fibrogenic + inflammatory signaling.
Català
Excited to share our recent paper “Pro-Fibrotic Immune Cells & FAPs Contribute to Skeletal Muscle ECM Remodeling and Fibrosis in Cancer Cachexia”
🧵 Summary of our findings below.
👇
journals.physiology.org/doi/prev/20250…
@b_veen17 @UofSCSOMC @UofSC @AJPCellPhys @USCResearch #myotwitter
English
Thomas Cardaci retweetledi
There's new #fibrosis info in this #ArticleinPress, Pro-Fibrotic Immune Cells and Fibro-Adipogenic Progenitors Contribute to Skeletal Muscle Extracellular Matrix Remodeling and Fibrosis in Cancer Cachexia (Thomas D. Cardaci et al. @UofSCSOMC):
ow.ly/Ku2N50X72JL
English
Thomas Cardaci retweetledi
From talented teams at @UofU3i and @UofUPT comes today's impressive #ArticleinPress. #Macrophage Immunometabolism - Emerging Targets for Regrowth in #Aging #Muscle (Zachary Fennel et al.):
ow.ly/R2iv50UPCew
English
Thomas Cardaci retweetledi
New graphical review now published! 🚨 Mechanistic Insight into Physical Activity Pleiotropy in Cancer Prevention
Read it here: brnw.ch/21wNIRV
#Exercise #Sport #Movement #ACSM #ExerciseOncology #PhysicalActivity #CancerPrevention
English
Thomas Cardaci retweetledi
New Article Alert! ✨
Multisymptom Burden in Cancer Survivors: Benefits of Physical Activity
Find it here: brnw.ch/21wNNp2
#Exercise #Sport #Movement #ACSM #ExerciseOncology #PhysicalActivity #Cancer
English
Thomas Cardaci retweetledi
The wide-ranging benefits of #PhysicalActivity and structured exercise offer a strong case for their role in reducing the negative effects of cancer and its treatments.
Learn more: brnw.ch/21wP6fW
#Exercise #Sport #Movement #ExerciseOncology #Cancer
English
Thomas Cardaci retweetledi
#PhysicalActivity #exercise can reduce #cancer risk
✅Control weight
✅Improve immune & inflammatory profile
✅Enhance colonic environment
✅Regulate sex hormone levels
👉🏽journals.lww.com/acsm-esm/fullt…
via @ESM_ACSM
English
Thomas Cardaci retweetledi
🚨🚨I’ll be speaking at the ISSN Tactical Summit on November 2, 2024 organized by @FireRescueWell and Drew Gonzalez
There is a fantastic line up of speakers, to include @drmyohead, @AJagim, @BM_Roberts_SkM, @DrJayDawes, @DrBobLockie, @DrCreatine, @FittoEnforcecom
English
Thomas Cardaci retweetledi
Today's #ArticleinPress is an APS Select article! Decreased skeletal muscle intramyocellular #lipid droplet-mitochondrial contact contributes to myosteatosis in #cancer cachexia (Thomas Cardaci et al. @UofSC):
ow.ly/TzJC50Toqb7
Română
Thomas Cardaci retweetledi
Congratulations! Thank you @TomCardaci for publishing with #AJPCell!
APS Publications@APSPublications
Congrats to Thomas D. Cardaci et al. for the #APSselect paper "Decreased skeletal muscle intramyocellular lipid droplet-mitochondrial contact contributes to myosteatosis in cancer cachexia" in @ajpcellphys @TomCardaci @UofSCSOMC ow.ly/6pEq50ThzMG
English
@TomCardaci I enjoyed your work much. Congratulations to @TomCardaci et al.
English
What a great way to end the week! Thanks for selecting our paper as an #APSselect paper!
APS Publications@APSPublications
Congrats to Thomas D. Cardaci et al. for the #APSselect paper "Decreased skeletal muscle intramyocellular lipid droplet-mitochondrial contact contributes to myosteatosis in cancer cachexia" in @ajpcellphys @TomCardaci @UofSCSOMC ow.ly/6pEq50ThzMG
South Carolina, USA 🇺🇸 English
