Our review comprehensively examines how different types of inflammatory cell death influence tumor growth and antitumor immunity, highlighting their potential to enhance cancer immunotherapy outcomes.
Our work offers a better understanding of the critical role of innate immune signaling in shaping tumor immunogenicity, highlighting the importance of targeting innate immune pathways for boosting anti-tumor immunity and immunotherapeutic efficacy.nature.com/articles/s4159…
@pouryany@NatImmunol Take a look at our work on early tumor editing and its implications for improving current immunotherapeutic efficacies. Special thanks to Pourya for working side by side with me to make this work possible.
Dr. Ying Zhang and collaborators found that early tumor editing preferentially suppresses innate immune signaling to reduce tumor immunogenicity, which can be reversed by inhibiting DNA methylation. #PKUResearchnature.com/articles/s4159…