Prof. Hao Wu

Ever wondered why only inflammasomes that use ASC, but not those that do not use ASC, can mature IL-1β? ASC helps to recruit pro-IL-1β to ASC for caspase-1 processing! See: "Inflammasome adaptor protein ASC is a mechanistic checkpoint in IL-1β maturation" pnas.org/doi/10.1073/pn…

I’m so excited and proud that my student Jennifer Wang @Jennnwww has received so many kudos for her Master’s thesis talk in Immunology @harvardmed! @ShivPillai4 Congratulations, Jennifer! @Luochen_Liu1 @jf033 @ZhoupingH @AhmetBugraTufa2 @PiXiong_3 @L_Heals

Excited to share our paper on the NLRP3 inflammasome condensate at the MTOC by "precise!" cryo-electron tomography (cryo-ET), in collaboration with Jue (phyllis) Wang@Phyllis23382012in the labs of Grant Jensen (BYU) and Pete Dahlberg (Stanford)! science.org/doi/10.1126/sc…

Excited to share an amazing video on the NLRP3 inflammasome pathway generated by talented Ann from the Iwasa lab @janetiwasa @Ann_HuiLiu. It shows the real cryo-EM structures of the pathway from #NLRP3, #ASC, #caspase-1, #GSDMD, #IL-1b, to #NINJ1. #cryoem @LeXiao17 Enjoy

Weight makes a difference ᵃᶦ

Excited to share an atlas and paper by summer interns depicting filament-forming proteins @ank_kan_95! They contain the most prevalent domains (e.g. DD, CARD, PYD) in innate immunity. #inflammasome #StructuralBiology #AlphaFold deathdomain.org pnas.org/doi/10.1073/pn…

What an exciting news and a huge honor! Our 2014 paper on ASC-PYD inflammasome filaments (Lu et al., Cell) has been recognized as a landmark in Cell’s "2014–2024 Timeline"! 🔥🔥🔥 #Inflammasome #PYD #StructuralBiology 🔗 cell.com/action/showPdf…

🎉🎉🎉 Professor Jia-huai Wang's new book, Proteins: A Structural Biology Perspective, is now out from Academic Press! 📖 Dive into the evolution of structural determination and AlphaFold! #StructuralBiology #Proteins #AlphaFold amazon.com/Proteins-Struc…

From bold resolutions, to big breakthroughs, CRI scientists including CRI Tech Impact Award Grantee Dr. Rik G.H. Lindeboom @NKI_nl are aiming to advance cancer research in many ways throughout 2025. Discover more New Year's resolutions in our newest blog: bit.ly/42ddE9V

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Tweetorial (1/13)👇with movies! Link: rdcu.be/d2mjm

BREAKING: President Biden will become the first President in American history to register job growth in every single month during his Presidency. This is huge.

I voted by mail today! Everyone should exercise their duty - there is no excuse that is big enough to justify not to vote.

@SjorsScheres I have exactly the same! But my baseline is 59 or 60 rather than 40s like you!

What’s better than going to a local symposium with only talks by students and postdocs? 9th SoCal cryo-EM symposium yesterday: dornsife.usc.edu/bridge-institu… amongst @CorneliusGati, Juli Feigon @FeigonLab, Hong Zhou, Dillon Cogan and Angie Walker. So fun to interact with trainees!

BREAKING: In a stunning moment at an event focused on fighting antisemitism, Donald Trump just announced that Jewish Americans need to have their head examined. Retweet so all Americans see this and know how vile Trump is.

BREAKING: Teamsters from Nevada and Michigan have just announced they are endorsing Kamala Harris. This is huge.

BREAKING: In a stunning leak, Donald Trump gave the keynote address at the Heritage Foundation where he announced the work the foundation did (Project 2025) would be crucial to his policy goals. Retweet so all Americans know Trump will enact Project 2025.

BREAKING: In a stunning admission, one of the most conservative Senators, Senator James Lankford, admits that it was Donald Trump who sabotaged the toughest border security legislation proposed in decades. Retweet to make sure every American sees this.

We’ve just finalized the program for our EMBO Inflammasome Workshop. 🙌 Next to many amazing short talks, we have an incredible lineup of poster presentations featuring lots of unpublished work. Check out the full agenda on our website—there’s still time to register! 👇

BREAKING: Mike Pence has just announced that he cannot in good conscience vote for Donald Trump. Retweet to make sure every American sees this clip.