AinSC
142 posts


A new shot literally regrows knee cartilage.
Researchers at Stanford Medicine have identified a novel strategy to regenerate articular cartilage in knees and potentially prevent or treat osteoarthritis (OA).
The method targets 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an age-related enzyme—or "gerozyme"—that accumulates in aging tissues and drives degeneration.
In aged mice, small-molecule inhibitors of 15-PGDH, delivered systemically or via intra-articular injection, promoted cartilage thickening and regeneration of functional hyaline articular cartilage.
This occurred without recruiting stem or progenitor cells; instead, existing chondrocytes underwent transcriptional reprogramming to a youthful state, with reduced populations of inflammatory and hypertrophic/degradative cells and expanded matrix-producing articular chondrocytes.
The inhibitors also reversed natural age-related cartilage thinning, improved joint function, and—when administered after simulated ACL injuries—strongly mitigated post-traumatic OA progression and associated pain.
Human OA cartilage explants from total knee replacements responded similarly in vitro, showing decreased degradation markers and evidence of new articular cartilage formation.
Given that an oral 15-PGDH inhibitor has already completed Phase 1 safety trials for age-related muscle atrophy, the findings open a path toward disease-modifying, regenerative therapies that could delay or obviate the need for joint replacement surgery.
[Agarwal, P., Su, S., Ancel, S., et al. (2025). Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration. Science. DOI: 10.1126/science.adx6649]

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Sunburn rates before 1900: minimal, despite people working outdoors 12 hours a day in fields, on boats, on roofs.
Sunburn rates after 1900: epidemic, despite air conditioning and office cubicles and SPF 50.
What changed? The fat in the food.
Your skin is built from the fats you eat. Saturated fat is stable under UV light. Polyunsaturated fat oxidises rapidly the moment the sun hits it.
Eat seed oils → PUFA gets built into skin cell membranes → UV light strikes unstable fat → oxidation → sunburn.
Eat saturated fat → stable membranes → UV tolerance climbs → natural sun protection from the inside out.
Your great-grandfather worked in fields all day on butter, lard, and dripping. He didn't burn. He didn't reapply anything. He didn't own a hat with a UPF rating.
You eat sunflower oil for 50 weeks of the year, then go to Spain for one and come back looking like a boiled lobster.
The sun hasn't changed. The sun is the same sun.
What changed is your cell membranes. They're now made from industrial fat that combusts under UV exposure like cooking oil left in a hot pan.
Carnivores consistently report dramatically improved sun tolerance. Not because meat contains SPF. Because saturated fat builds UV-resistant skin.
You've been blaming the sun for damage caused by what you ate 18 months ago.

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@Marion436842126 @grok is this true and what are the safer alternatives
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@SamaHoole @grok. is this accurate and can you recommend any brands that are pure?
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Italian olive oil is one of the most adulterated products in the global food supply. Estimates suggest 70 to 80% of "extra virgin olive oil" sold worldwide is either mislabelled lower-grade oil or cut with cheaper seed oils.
The fraud is run by organised crime. The 'Ndrangheta operates olive oil adulteration rings that generate more profit than cocaine trafficking. They import cheap oil from Tunisia, Morocco, and Turkey, relabel it as Italian, and export it at premium prices to people who think they're buying authenticity.
Or they cut extra virgin with refined olive oil, lampante (lamp oil grade, unfit for human consumption), or seed oils like sunflower and soybean, then sell the mixture as pure extra virgin to supermarkets and restaurants.
The Italian government knows. The EU knows. Occasional busts happen, the headlines run for a week, the fraud continues. The margins are enormous. The penalties are a rounding error.
Even the legitimate stuff has problems. Intensive olive cultivation in Spain has eroded hillsides, drained aquifers, and contaminated groundwater with pesticide runoff. Traditional groves are being torn out and replaced with high-density intensive plantations that demand irrigation in arid climates, heavy spraying, and mechanical harvesting that wrecks the soil.
The waste water is highly polluting. Every litre of olive oil produces 1 to 1.5 litres of effluent loaded with organic compounds, phenols, and residual oil. It gets dumped in evaporation ponds or discharged with token treatment.
Your £12 bottle of "Italian extra virgin" is probably mislabelled Tunisian oil cut with sunflower, possibly sold by organised crime, definitely draining a Mediterranean aquifer, and generating toxic waste at the press.
But it's from plants. So it's definitely healthier than butter from a British dairy cow grazing on rain-fed grass three miles down the road.

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Best gray hair reversal article on the Internet
get your pens and papers out, take notes, and reread it until it sticks.
Dont forget to enjoy
Moosa@questmoosa
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My doctor put me on a statin after my heart attack at 52.
I trusted him. I took the pill. I never asked a question.
Then I found this study. 60 clinical trials. 323,950 people. Every cholesterol lowering drug ever made. Statins. PCSK9 inhibitors. Ezetimibe.
They measured how much each drug lowered LDL cholesterol. Then they measured whether people lived or died.
The line is flat.
It did not matter if they lowered LDL by 10% or by 70%. The death rate did not change. In some trials people died more.
323,950 people. Near zero benefit. Published in the Journal of Cardiovascular Pharmacology. 2023.
Nobody showed me this chart. Not my cardiologist. Not my pharmacist. Not the drug rep who visited my doctors office every month.
I had to find it myself. After the heart attack.

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@FarmGirlCarrie @grok. Is this true and what evidence exists to comfirm this perspective
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Ambassador Stevens was sent to Benghazi to secretly retrieve US made Stinger Missiles that the State Dept had supplied to Ansar al Sharia in Libya WITHOUT Congressional oversight or permission.
Sec State Hillary Clinton had brokered the Libya deal through Ambassador Stevens and a Private Arms Dealer named Marc Turi, but some of the shoulder fired Stinger Missiles ended up in Afghanistan where they were used against our own military.
On July 25th, 2012, a US Chinook helicopter was downed by one of them. Not destroyed only because the idiot Taliban didn't arm the missile. The helicopter didn't explode, but it had to land and an ordnance team recovered the missile’s serial number which led back to a cache of Stinger Missiles kept in
Qatar by the CIA.
Obama and Hillary were in full panic mode, so Ambassador Stevens was sent to Benghazi to retrieve the rest of the Stinger Missiles. This was a "do-or-die" mission, which explains the Stand Down Orders given to multiple rescue teams during the siege of the US Embassy.
It was the State Dept, NOT the CIA, that supplied the Stinger Missiles to our sworn enemies because Gen. Petraeus at CIA would not approve supplying the deadly missiles due to their potential use against commercial aircraft.
So then, Obama threw Gen. Petraeus under the bus when he refused to testify in support of Obama’s phony claim of a “spontaneous uprising caused by a YouTube video that insulted Muslims.”
Obama and Hillary committed TREASON!
THIS is what the investigation is all about, WHY she had a Private Server, (in order to delete the digital evidence), and WHY Obama, two weeks after the attack, told the UN that the attack was the result of the YouTube video, even though everyone KNEW it was not.
Furthermore, the Taliban knew that the administration had aided and abetted the enemy WITHOUT Congressional oversight or permission, so they began pressuring (blackmailing) the Obama Administration to release five Taliban generals being held at Guantanamo.
Bowe Bergdahl was just a useful pawn used to cover the release of the Taliban generals. Everyone knew Bergdahl was a traitor but Obama used Bergdahl’s exchange for the five Taliban generals to cover that Obama was being coerced by the Taliban about the unauthorized Stinger Missile deal.
So we have a traitor as POTUS that is not only corrupt, but compromised, as well and a Sec of State that is a serial liar, who perjured herself multiple times at the Congressional Hearings on Benghazi.
Perhaps this is why no military aircraft were called upon for help in Benghazi: because the administration knew that our enemies had Stinger Missiles that, if used to down those planes, would likely be traced back to the CIA cache in Qatar and then to the State Dept’s illegitimate arms deal in Libya.

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When you cook a kilo of ground beef in the pan, and the fat renders out and pools around the meat in a shining golden puddle.
Stir it back in.
Do not drain it. Do not tip it into the sink. Do not blot it with a piece of kitchen roll as though you have caught the meat doing something shameful.
That puddle is the nutrition.
"But it's greasy."
Yes. That is the point. That is the bit your body has been asking for all afternoon. The fat carries the fat-soluble vitamins, A, D, E, and K2, out of the animal and into you. It carries the calories that keep you full until tomorrow. It carries the satiety signal that stops you opening the cupboard at nine o'clock looking for something to finish the evening.
Drain it, and you are left with lean protein, which is an incomplete food. It is the half of the animal the spreadsheet approves of. It is not the half that feeds you.
The modern instinct is to drain, because we have been taught for sixty years that fat is the enemy. The ancestral instinct is to preserve every last drop of the stuff, because fat was survival, and any woman who threw rendered beef fat down the sink in 1920 would have been talked about in the village for a week.
Your great-grandmother cooked in the fat, served in the fat, and poured the leftover drippings into a bowl on the cold shelf to fry tomorrow's eggs in.
You are pouring it down the sink and wondering why you are hungry again at three.
Stir it back in. She was right the first time.

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This literally blew my mind
There is a healthcare law called ‘The Medical Loss Ratio Rule’
This law says any money you pay in healthcare premiums, the insurance company must spent 80% on your healthcare
If they don’t, they’re supposed to refund you
Yes, this is real
Insurance companies found a loophole. They bought the doctors, the pharmacy benefits managers, the pharmacies and the clinics
Now, they skyrocket prices on everything from doctors visits, tests and prescriptions so that your 80% is spent
But it’s not really spent, they’re just paying themselves inflated prices so it actually doesn’t cost them anything. They just pocket all the money and never have to refund premiums
This provision is written in the Affordable Care Act, called the 80/20 rule
80% must be spent on care or refunded, 20% can be profit for the insurance company
We are being robbed blind
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🔻 THE OBAMA FILES ARE WORSE THAN WE THOUGHT.
His lawyers didn’t show up to negotiate.
They showed up to BEG.
Here’s what Bondi’s team found inside the Tehran servers under Obama’s codename — RENEGADE:
— 14 wire transfers to a Swiss account linked to Hezbollah between 2014-2016. Total: $1.7 billion. The same $1.7 billion he told Congress was “frozen Iranian assets.”
— A signed directive authorizing the CIA to stand down during the Benghazi attack. Not typed. HANDWRITTEN.
— Communications with Epstein’s handler, dated March 2015, discussing “the island arrangement” and “the Chicago package.”
— A backchannel to Tehran through Valerie Jarrett, active from 2012 to 2024. Yes. 2024. Two years AFTER he left office.
He didn’t just betray America.
He was running a shadow government from his basement in D.C. while pretending to be retired.
His lawyers are now offering FULL COOPERATION in exchange for immunity.
Trump said no.
No deals. No mercy. No escape.
The man who divided America for 8 years is about to face the America he tried to destroy.
And she’s awake.
FOLLOW ME, THE NEXT DROP WILL BE SHOCKING
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@ctlyle1 @AmericanAir We have the same experience. American offered us a chance to keep our executive Platinum status for almost $3000 and probably over the course of two years and more than 40 flights who might’ve had one upgrade.
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I have platinum status on @AmericanAir. The first year, I got upgraded fairly often…maybe once out of every 4/5 flights.
The last few years of retained status, I’ve been upgraded 1-2x, flying fairly frequently and mostly American hubs. Wonder what changed…
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@AmericanAir The hundred stands for the percent of unsatisfied customers
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One hundred years. Countless memories. One incredible ride. ✈️ Our centennial is built on every journey, every moment and every story that has shaped who we are today. Here's to the next chapter of what's to come. #American100 #ForeverForward
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🚨BREAKING:🚨The Maricopa County Board of Elections has come forward to issue an apology to President Trump, stating that elections officials in the county have now brought forth evidence alleging that then Secretary of State (now Governor) Katie Hobbs and then Speaker of the Arizona House of Representatives Rusty Bowers PERSONALLY ORDERED THEM TO DESTROY TENS OF THOUSANDS OF MAIL-IN BALLOTS FOR PRESIDENT TRUMP and to count the TENS OF THOUSANDS OF BALLOTS THAT WERE CAST BY ILLEGAL ALIENS FOR JOE BIDEN in Arizona's largest county in the 2020 election. This was "outcome-determinative fraud" by the very individuals who were entrusted to conduct, oversee and certify the election and Hobbs and Bowers are both alleged to have been on the payroll of at least 3 hostile foreign governments, The George Soros Open Society Foundation and The DNC in exchange for RIGGING the 2020 election in Arizona. Put simply, there is now IRREFUTABLE AND INDISPUTABLE PROOF that President Trump WON the state of Arizona in that STOLEN election out of the mouths of the very people who counted the votes. LOCK THESE TREASONOUS CROOKS UP NOW! 💪🏻🔥🇺🇸


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🚨BREAKING:🚨FEDERAL AUTHORITIES HAVE REPORTEDLY QUIETLY SEARCHED THE HOME OF DISGRACED FORMER PRESIDENT BARACK OBAMA persuant to a warrant related to their MASSIVE GRAND JURY RUSSIAGATE INVESTIGATION in the southern district of Florida. Obama's lawyers were reportedly alerted to and present at the time of the search, along with the former President and his husband Michelle. It is FINALLY HAPPENING... THE HAMMER OF JUSTICE IS ABOUT TO COME CRASHING DOWN ON THE MOST CORRUPT PRESIDENT IN THE HISTORY OF OUR COUNTRY. It's a great day in America!!! 💪🏻🔥🇺🇸


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