Christopher Smillie

Excited to share the Smillie Lab's first paper! We discovered distinct lineages of the gut microbiota that are exquisitely adapted to inflammatory disease. This was a monumental effort led by Adarsh Kumbhari @mgh_ri @harvardmed @broadinstitute More: doi.org/10.1016/j.chom…

@Nature @heidiledford Our recent work: Discovery of disease-adapted bacterial lineages in inflammatory bowel diseases cell.com/cell-host-micr…

Excited to see our recent paper profiled by @Nature! Thanks to @heidiledford for the fantastic article. Congratulations to the Lee and Doffinger labs on their recent discoveries. Exciting times for IBD research! nature.com/articles/d4158…

@Nature @heidiledford The two other publications covered in the article: A disease-associated gene desert directs macrophage inflammation through ETS2 nature.com/articles/s4158… Autoantibodies against Interleukin-10 in Inflammatory Bowel Disease nejm.org/doi/10.1056/NE…

Many thanks to @adarsh_k1, @thomasnhcheng, @AshwinMDIBD, @bkocharmd, and @TheXavierLab on this team effort!

Excited to share the Smillie Lab's first paper! We discovered distinct lineages of the gut microbiota that are exquisitely adapted to inflammatory disease. This was a monumental effort led by Adarsh Kumbhari @mgh_ri @harvardmed @broadinstitute More: doi.org/10.1016/j.chom…

PhD opportunities to join our lab! IMPRS is a great graduate school. Check it out! Deadline for applications: May 15th - contact us if interested 😉

Congrats Itzhak Khait, @Ohad_LE, and @HadanyL for their brilliant use of #ML to study plant communication by sound! Ohad is a new postdoc in our lab who is studying how the #microbiome controls its human host - excited to see what he comes up with next! cell.com/cell/fulltext/…

Also congrats to Shivam Gandhi on his stellar contributions to this paper! He will make an amazing graduate student this fall.

Congrats to our collaborators Peijun Ma and Deb Hung on publication of BacDrop, a new method for bacterial #singlecell RNA-seq. Highly scalable methods will be essential for studying the transcriptional heterogeneity of pathogens and the #microbiome. cell.com/cell/fulltext/…

Very excited to share our work that defines how dopamine and acetylcholine interact in the brain during decision making! biorxiv.org/content/10.110…

Great lab @HarvardChanSPH for genomics, lung biology, and asthma!

Congratulations to Fatima Hussain @fatiays and @JavierDubert on their new paper in Science describing surprising ways how bacteria in the wild defend themselves against phage. See also perspective by Perspective by Meaden and Fineran. science.org/doi/10.1126/sc…

The Smillie Lab is hiring for an exciting collaboration @broadinstitute to identify microbiome products that control gut disease. We are a new computational lab @harvardmed @mghmedicine studying #microbiome #immunology #metabolomics #ML. Please share! smillielab.org

We are excited to share our study on spatially organized multicellular immune hubs in human colorectal cancer cell.com/cell/fulltext/… @CellCellPress. Joint effort with @karin_pelka, @chenchirps, @AnaAndersonlab, Orit Rozenblatt-Rosen, Aviv Regev, Nir Hacohen, many others!

I am incredibly excited to share our preprint ‘Somatic mutation rates scale with lifespan across mammals’In this paper we provide an unprecedented description of somatic mutation across mammals. biorxiv.org/content/10.110… An illustrated tweetorial…[1/17]

Happy that our single-cell meta-analysis of SARS-CoV-2 entry genes is out @NatureMedicine. Headed by Chris Muus & @MDLuecken in a big effort of the whole @humancellatlas Lung Network, we find age&sex-dependent cell-type specific effects across 31 studies. nature.com/articles/s4159…

The Smillie Lab opens March at @MGHMedicine! We develop methods (wet/dry) to understand microbial life on the human body #microbiome #singlecell #evolution #deeplearning. Hiring grad students, postdocs, and RAs @harvardmed @broadinstitute. Please share! smillielab.org

Today we report the use of base editing in patient-derived cells and in mice to correct the most common cause of progeria, the devastating rapid aging disease. Progeria is typically caused by a dominant negative C•G-to-T•A point mutation in LMNA. 1/11 drive.google.com/file/d/1oH4W0z…

Really excited to see our work out mapping the development of the human intestine at single cell resolution. An amazing amount of work from a fantastic team. cell.com/cell/fulltext/…

Proud to share our latest work showing that interactions between strains govern the eco-evo dynamics of microbial communities, led by Akshit Goyal @eltanin4, Leonora Bittleston @leonorabit and Gabriel Leventhal @gaberoo ... biorxiv.org/content/10.110…