Xavier Lab

Check out this @NatureMedicine Comment about the importance of studying heritage diets and the World Diet Initiative’s efforts to translate dietary diversity into health benefits for the global community: nature.com/articles/s4159…

Join us and @GeneLayInst on July 31st for the Annual Symposium! This year's speakers include Marco Colonna, Shimon Sakaguchi, @stefanispranger, and @victora_lab. Register using the QR code in the flyer! #inflammation #immunity #disease #genelayinstitute

Good luck at UCSF (Anna), University of Washington (Regan), and MIT (Tanvi). We will miss you!

It's that time of year again--we are saying goodbye to more of our youngest and brightest lab members as they transition to the next steps of their careers, either in grad school or in other institutions. This week, we are saying goodbye to Anna, Regan, and Tanvi.

New website launch for the World Diet Initiative—an international effort to map global dietary patterns and their impacts on human health. The site is now accepting heritage diet submissions to build the open-access World Diet Atlas. worlddietinitiative.org

Congratulations, @SachaLEBON on some great work! Excited to see this come out after all your hard work.

Early-life interventions & airway microbiome Nasal microbial gene atlas in infants w/cystic fibrosis. Hypertonic saline inhalation reshapes microbiome, selects salt-tolerant H. influenzae & ⬆️transporters linked to antibiotic tolerance @TheXavierLab cell.com/cell-host-micr…

What the nose knows of cystic fibrosis microbes and hypertonic saline Bouzek Previews work by @TheXavierLab presenting microbial gene atlas of nasopharyngeal swabs in infants w/cystic fibrosis & healthy controls & IDing impacts of clinical interventions cell.com/cell-host-micr…

Excited to share this new preprint from a large collaborative effort using #exome + #genome sequencing, moving beyond GWAS to implicate 68 genes in #IBD through rare protein-coding variation. bit.ly/43h72GA @broadinstitute @MGHMolBio @MGBResearchNews

Excited to share our new @ImmunityCP review, discussing how advances in functional genomics and chemical biology are enabling the translation of IBD genetics into mechanistic understanding and new therapeutic hypotheses. cell.com/immunity/fullt… #IBD #inflammatoryboweldisease

We found and validated in vitro that early-life perturbations (hypertonic saline inhalation therapy) can select for microbial traits linked to salt and antibiotic tolerance. #antibiotics #cysticfibrosis #microbial @broadinstitute @MGBResearchNews

Out now @cellhostmicrobe! In collaboration with @RuthSteinbaer and Swiss clinicians, we built the largest nasal microbial gene atlas in infants w/ and w/o cystic fibrosis to date (cont.)

Our latest work, with @MikaKivimaki lab, now online @alzdemjournals: we used single-cell and GWAS data to uncover genes in peripheral blood immune cells associated with Alzheimer’s disease. doi.org/10.1002/alz.71… @broadinstitute @MGHMolBio @MGBResearchNews #Alzheimers

New work with @CarolineUhler, now online in @NatureComms! We developed TRIM, a multimodal framework integrating T cell RNA and TCR profiling to predict T cell responses to cancer treatment. nature.com/articles/s4146… @broadinstitute @MGHMolBio @MGBResearchNews

@MGBResearchNews @MGHMolBio @broadinstitute

New study, in collaboration with @Honda1Kenya, out now in @Nature. We show how a low protein diet drives a microbiota-dependent induction of thermogenic brown adipocytes via FXR & FGF21 pathways. nature.com/articles/s4158…

@MGBResearchNews @MGHMolBio @broadinstitute

Excited to share our new study defining the multicellular ecosystem of atopic dermatitis. Integrating >700k single cells from healthy and inflamed skin, we uncover disease-specific immune circuits linked to disrupted keratinocyte differentiation. nature.com/articles/s4146…

Thank you to all the authors, including @dalygene and @masakanai for their hard work and contributions! @MGBResearchNews @MGHMolBio

This paper charts a clear path to understanding how genetics can not only find the genetic variants linked to a disease, but also dissect them into clearly distinct groups that represent independent components of the disease. (3/4) nature.com/articles/s4158…

Check out this great write-up of a recent study between the @broadinstitute, University of Helsinki, and other institutions which has found more than 400 genetic markers that are linked to autoimmune hypothyroidism (AIHT). (1/4) broadinstitute.org/news/study-rev…