Xavier Lab

New work with @CarolineUhler, now online in @NatureComms! We developed TRIM, a multimodal framework integrating T cell RNA and TCR profiling to predict T cell responses to cancer treatment. nature.com/articles/s4146… @broadinstitute @MGHMolBio @MGBResearchNews

@MGBResearchNews @MGHMolBio @broadinstitute

New study, in collaboration with @Honda1Kenya, out now in @Nature. We show how a low protein diet drives a microbiota-dependent induction of thermogenic brown adipocytes via FXR & FGF21 pathways. nature.com/articles/s4158…

@MGBResearchNews @MGHMolBio @broadinstitute

Excited to share our new study defining the multicellular ecosystem of atopic dermatitis. Integrating >700k single cells from healthy and inflamed skin, we uncover disease-specific immune circuits linked to disrupted keratinocyte differentiation. nature.com/articles/s4146…

Thank you to all the authors, including @dalygene and @masakanai for their hard work and contributions! @MGBResearchNews @MGHMolBio

This paper charts a clear path to understanding how genetics can not only find the genetic variants linked to a disease, but also dissect them into clearly distinct groups that represent independent components of the disease. (3/4) nature.com/articles/s4158…

Check out this great write-up of a recent study between the @broadinstitute, University of Helsinki, and other institutions which has found more than 400 genetic markers that are linked to autoimmune hypothyroidism (AIHT). (1/4) broadinstitute.org/news/study-rev…

1/ Our paper is out today in @CellSystemsCP. We used protein language models and deep learning to identify candidate protease allergens in the human microbiome. cell.com/cell-systems/f…

2/2 For an in-depth walkthrough, check out this Tweetorial by first author @k00kumar. x.com/k00kumar/statu…

1/2 New paper out now in Cell Systems @CellPressNews describing development of a deep learning framework to predict allergenic microbial proteases! sciencedirect.com/science/articl… @broadinstitute @MGHMolBio @MGBResearchNews

We’re looking forward to the upcoming 2nd International Conference on Individualized Infection Medicine in Hannover, 19–21 March 2026. Registration is still open! #c13097" target="_blank" rel="nofollow noopener">ciim-hannover.de/aktuelles/symp… #CIIM #infection #medicine

Nice to see our recent CARD9 work covered in @NatRevDrugDisc, with a focus on our two-step screening approach for identifying binders of challenging targets. nature.com/articles/d4157…

Congratulations to @jaiswal_ok and all the authors! @broadinstitute @MGHMolBio @MGBResearchNews

Excited to share our latest study in Cell Genomics, combining single-nucleus RNA-seq, spatial transcriptomics, and histology to dissect the molecular determinants of lung fibrosis! cell.com/cell-genomics/… #fibrosis #lung #ILD

Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases dlvr.it/TQVghs

@broadinstitute @MGHMolBio @MGBResearchNews

These studies firmly establish a foundation for development of an inhibitor of CARD9 inflammatory response. More broadly, this approach illustrates a strategy for using human genetics & chemical biology to guide small-molecule discovery against challenging immune targets. (7/7)

New work, now online in @CellCellPress! Using a phased, binder-first strategy, we identified a ligandable pocket on CARD9 and discovered a small-molecule inhibitor of CARD9 inflammatory signaling. (1/7) sciencedirect.com/science/articl…