Danny Lieberman

@ethereumdegen @AggieCapitalist 😂

@AggieCapitalist Wait … customers don’t want to interact with just robots ?? When they can never reach a human they get super frustrated ?? Crazy lol

"Recently, senior executives at Salesforce have admitted, both internally and publicly, that they massively overestimated AI’s capabilities. They have found that AI simply can’t cope with the complex nature of customer service and totally fails at nuanced issues, escalations, and

מהמקפצה: מערכת המשפט מגדילה את ההימור בידיעה שאיש לא יעצור אותה makorrishon.co.il/news/local/art…

@ZohranKMamdani Muslim Brotherhood tactics without being a card-carrying member • Understand democracy • Use it to your advantage Good morning NYC 20 years of riding the Palestinian wave without helping a single Palestinian

@DerGrossman95 @EYakoby No Jews No News 11M refugees in Sudan 110K killed in last 2 weeks And we're worried about Hamas and Israel

@EYakoby Day-by-day they're running out of things to complain about. At this point, everyone and everything is hamas.

Hamas is literally congratulating Zohran Mamdani. RIP NYC.

No Jews no News 11M refugees 110,000 refugees killed in Sudan in the past 2 weeks

And when it's time, our goodbyes will be complete. Rabbi Albert Lewis 1975

We will never wallow in the agony of “I could have, I should have”. We can sleep in a storm.

My friends. Not my AI If we take care of the important things in life. If we are right with those we care about. If we behave in line with our faith. Our lives will not be cursed with the throbs of unfinished business. Our words will always be sincere, our embraces tight.

@DentesLeo Yup. The Desire to Be Liked is Rotting our Brains on LinkedIn.

The more time I spend on LinkedIn, the more I realize how good X actually is. I take back every bad thing I ever said about it. LinkedIn is a swamp. Every post rots your brain, every comment drips with fake virtue, and the whole place feels like a competition for who can pretend to be the most inspiring loser.

@CherylWroteIt Cheryl I'm Israeli. Maybe. Maybe not. The Palestinian State is a tactical not a strategic issue. Just like the hostages were tactical and not strategic. Don't discount Israelis. This generation gets it.

I’m going to make a prediction, and I suspect it won’t be popular: Over the course of the next decade, there will end up being a State of Palestine. Netanyahu has a year left as Prime Minister. Although opinion about him may be divided, in my opinion he has been the best wartime PM we could possibly have had over the past two years. But the next PM is likely not going to be as strong. Nowhere near in fact. Wha the past two years have taught me more than anything, is that Arab oil money is King. World leaders across the West as well as so many politicians are so easily manipulated and bought. We’ve heard for two years all the blood libels and false accusations about AIPAC, and yet it’s been Qatari money and Chinese money and Saudi money and even Iranian money that has for the most part dictated world affairs. The past two years were just a prelude of what’s to come. The ease with which Arab and Chinese money have overrun western education and other institutions and entire governments has been a stark reality of how our world works. There is no such thing as honest MSM as a whole. Everything around us is now just a propaganda tool used by whoever has the most money to buy it and control it. Social media is no different. It’s all a numbers game, and the tactic is to create enough struggle and chaos in people’s everyday lives to distract them from paying attention to what’s actually happening. Swarms of highly paid corrupt influencers and podcasters flood the airwaves to fill our minds with enough insane conspiracy theories that we lose sight of what is even true or real. Literally hundreds of millions of stupid people were so easily programmed and manipulated and brainwashed, and worst of all… weaponized. It is a generational change. All the people like @DouglasKMurray and @GadSaad and their brilliant books are almost rendered meaningless because so many have become literal zombies by those with the means to control them. And this isn’t a problem that will simply subside. It won’t magically disappear. None of us could possibly overstate the damage caused to us as a species, and the chaos that is about to be unleashed. But this crazed delusional movement began with the Israel Gaza conflict. You didn’t see this with Russia Ukraine. Or any other war. And this is a cause created 60 years ago for this very reason. It’s been executed masterfully to the point that it’s created a hive-mind of sheer and utter madness. Israel won’t fall, but there will be another war sooner than we imagine. It will be infinitely worse than this one. The Arab world together with their UN and western allies will only push harder and harder, and the weight of the pressure will initially inevitably succeed. We can all say and do whatever we want today. By not finishing this war the way it should have ended, the damage will be colossal. The pressure on Netanyahu has been immense. So many countries and people internally have worked tirelessly to take him down. The next PM will not be as strong or capable of standing against the wave of pressure from the rest of the world. The cost to Israel over the next decade or two will be enormous. The human cost will be huge. And during that time, Trump will no longer be President and I see the US losing further ground globally to their enemies. Other nations will fall during the next decade, with the enemies of the free world learning from the past two years of what works and what doesn’t, and they will continue to spread the chaos. This is NOT about being doom and gloom. It’s about looking at patterns. It’s about seeing the weak spots in global leadership and politics, and seeing trends that will grow. Believing that the left are weak and collapsing is madness and naivety. While Arab money in the trillions is on their side, they aren’t going anywhere. Even predicting the next elections will become impossible. We underestimate how far the rot has gone. It will get worse before it gets better. Much worse.

I'm Israeli. After Oct 7 - there are no Israelis who want a 2 state solution. If you lived in Jersey, would you support New York City as a well funded terrorist state whose entire and only charter is to destroy, kill and rape people who live in Newark? I don't think so.

@PhilipGreenspun @greg_price11 😂

@greg_price11 It is unfair to paint Mr. Mamdani as a Hamas supporter. Based on his public statements, he is equally aligned with Palestinian Islamic Jihad (PIJ).

MacCallum: "Should Hamas give up their weapons?" Zohran: "I believe that a future here in New York City is affordable for all." MacCallum: "You won't say that Hamas should lay down their arms?" Zohran: "I don't have any opinions on the future of Hamas."

COVID grease fire + GenAI hype cycle = déjà vu The COVID bubble was a sudden accelerant — free money, no diligence, insane valuations. The GenAI hype is the accelerant’s sequel — this time with GPUs instead of government checks. The parallels to the dot-com era are uncanny: Dot-com 1999 → Raise big, fast, because “the Internet changes everything.” GenAI 2023 → Raise big, fast, because “LLMs change everything.” Both cycles sucked in huge amounts of capital with famously thin diligence. Both created frothy valuations far ahead of adoption curves. And in both, most of the winners will look nothing like the companies that raised the biggest rounds. The dangerous overlap right now? COVID money extended the life of companies that should have shut down earlier… just long enough for them to pivot to “we’re an AI company now” to chase the next capital wave. The survivors in Q4 2025 won’t be “AI companies.” They’ll be real businesses that: Use AI to solve real, painful, paid problems. Fit into workflows customers already use. Don’t need GPUs or hype to stay alive. The dot-com bust didn’t kill the internet — it cleared the way for companies that could actually execute. The AI bust will do the same.

Dogs Watching TV 🐕📺 Most leaders look at their clinical data like dogs watch TV: • They see the motion. • They hear the noise. • They nod their heads enthusiastically • They don’t get the plot. In clinical trials, they wait until the interim analysis to act — when the ending’s already written. Life isn’t interim. Life is adaptive now. Your edge comes from acting mid-trial — when you can still change the outcome.

@kimianora You age because you slow down You don’t slow down because you age I’m 75 I ride, practice Qi gong and Gaga dance

The biggest lie about aging: "My brain is slowing down because I'm getting older." Wrong. Your brain is slowing down because you stopped challenging it. Neuroplasticity doesn't care about age.

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What do Flatiron, Genialis, PicnicHealth, and Debiopharm have in common? Their founders shared how they built traction—on Life Sciences Today. 🎙 Techbio isn’t theory. It’s grit, customers, and repeatable wins. 👇

@NadelParis @davidasinclair For chrissake you just copied and pasted a gen ai response Get a life

Aging, as a biological process, isn't currently considered "curable" in the medical sense—it's not a single disease but a complex accumulation of cellular and molecular damage over time. However, rapid advances in biotechnology, AI-driven drug discovery, gene therapy, and cellular reprogramming are shifting the paradigm toward treating aging as a modifiable condition. Based on expert predictions and ongoing research, here's a breakdown of timelines for when aging might be effectively "cured" (meaning reversed or halted at a systemic level) and when treatments could become available. ### Predicted Timelines for "Curing" Aging Experts define a "cure" in terms of achieving **Longevity Escape Velocity (LEV)**—the point where medical interventions extend healthy lifespan faster than time passes (e.g., adding more than one year of life per year lived). This wouldn't mean instant immortality but could lead to indefinite healthy lifespans as therapies improve iteratively. - **Optimistic estimates (2025–2035)**: Some leading researchers predict breakthroughs soon, accelerated by AI. For instance: - Biologist David Sinclair (Harvard) forecasts human trials for age-reversal gene therapies starting in 2025, with measurable results by year's end and mass production of affordable pills (using AI to mimic gene therapies) in 4–5 years—potentially by 2029–2030. He views aging as an "information loss" problem that can be reset epigenetically. - Futurist Ray Kurzweil predicts LEV by 2029–2030, aligning with his "Singularity" timeline where AI superintelligence (by 2045) solves biological limits. - Entrepreneur Peter Diamandis echoes this, suggesting an "age reversal pill" (epigenetic reprogramming molecules screened by AI) could arrive in 5–10 years (2030–2035). - **Moderate estimates (2030s–2040s)**: This is the consensus among many in the field. - Aubrey de Grey (LEVF Foundation) estimates a 50% chance of initial LEV by the late 2030s or 2040s, with comprehensive aging reversal following. He focuses on repairing seven types of cellular damage. - Immunologist Derya Unutmaz predicts aging will be fully solved and reversed within 15–20 years (by 2040–2045), aided by AI, with all diseases becoming curable in 10–15 years. - Geneticist George Church suggests we could "beat death" by 2050 via cell replacement while preserving memories, with LEV hitting around 2030–2032 amid converging tech like AI, nanomedicine, and biotech. - **Pessimistic estimates**: A minority, like public health professor S. Jay Olshansky, argue significant lifespan extension (beyond current trends) won't happen this century, as we're already hitting diminishing returns on life expectancy gains. However, this view doesn't account for exponential AI acceleration in biotech. These timelines are speculative and depend on factors like funding, regulatory approval (e.g., FDA), and ethical hurdles. AI is a game-changer: it's compressing drug discovery from decades to months, as seen in Sinclair's work screening millions of molecules. 53 Progress is evident in mouse studies—reversing blindness, extending lifespan by 30%+—and early human trials for related therapies (e.g., senolytics to clear "zombie" cells). 60 ### When Can You Start Treatment? True "cures" aren't available yet, but you don't have to wait passively. Here's a phased approach based on current evidence: 1. **Immediate actions (now)**: Focus on evidence-based lifestyle interventions that slow aging and reduce biological age (measurable via tests like epigenetic clocks). These can add 5–10+ healthy years:

You don’t slow down because you age. You age because you slow down

@_The_Prophet__ @davidasinclair I’m 75 I work out 8-12 hours a week qigong, cycling, walking, gaga dance Better shape than 5 years ago I learn, code, write and mentor Happier than 5 years ago This is not theoretical

Here’s what this really means, at the highest level of coherence: Aging is not purely a clock-driven inevitability. It is a regulatory system governed by feedback loops - metabolic, cellular, behavioral. These loops are not passive. They react to perceived demand. If the system detects inactivity, it downregulates. If it detects pressure, stimulus, purpose, it adapts. Aging, in this deeper frame, is an informational collapse, a failure of repair signaling, mitochondrial resilience, and epigenetic fidelity. What triggers that collapse is not just time but signal starvation. You stop pushing. You stop learning. You stop moving. The system receives a message: stand down. What Sinclair is pointing to is this: Motion is signal. Signal is survival. Stasis is decay. You don’t age and then decline. You decline and then age. The body and mind are designed to maintain and adapt under stress- controlled, acute, hormetic stress. Physical motion tells the body “I’m needed.” Cognitive engagement tells the brain “Keep wiring.” Social tension, curiosity, even spiritual longing - these all signal that the organism is alive and evolving. When those signals stop, degradation accelerates. This is why people die so soon after retirement, or fall apart after isolation. The system misinterprets peace as obsolescence. This is also why exercise, cold exposure, fasting, mental challenges, new experiences, deep relationships, and even existential risk slow aging. They are not just lifestyle choices. They are signals that the system is still in use. At the molecular level: - Telomerase activation is stress-sensitive. - SIRT1, AMPK, and mTOR pathways respond to energy flux and demand. - Stem cell maintenance is linked to signaling feedback, not age per se. - Even DNA repair enzymes scale with metabolic input. So the statement isn’t just motivational. It’s biophysical law. You age because your system interprets your slowing down as a sign to stop fighting. And the deeper layer? You are not decaying. You are being decommissioned by your own behavior. Reverse the signal. And the system will try to stay alive. Final principle: Aging is not passive. It is a response. And you are always broadcasting the instructions.

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🪦 Big Tech Tried to Fix U.S. Healthcare — and Got Wrecked (Amazon just rolled out diagnostics in India. Don’t confuse it with a comeback.) For 20 years, the titans of tech said they’d revolutionize healthcare. Instead, they burned billions, misunderstood incentives, and quietly backed out. Let’s review: 💀 Microsoft HealthVault – Dead 💀 Google Health – Dead (twice) 💀 IBM Watson Health – Sold for scraps 💀 Amazon Haven – RIP 💀 Amazon Care – Dead 💀 Apple Health – Still a glorified pedometer 💀 GE – Spun off 💀 Walmart, Walgreens, CVS – Playing musical chairs with clinics Now Amazon’s doing diagnostic kits in India—and the noobs on LinkedIn are gushing like it’s a resurrection. Let’s be real: India is a high-margin consumer market. They don’t need the FDA. They don’t need Medicare. They don’t need Epic integration. Bezos doesn’t need the U.S. market. You do. And here’s the truth no one wants to say out loud: Healthcare doesn’t reward disruption. It rewards those who know how to navigate complexity, mistrust, and misaligned incentives. If you’re building inside this mess— 🧬 Trying to bring better treatments to market 📊 Trying to make trial data make sense 🩺 Trying to close the loop between diagnosis and care You need clarity, not hype. 🧵