David Sinclair

Just remember: Your coworkers will NOT be there for you in the last chapter of your life.

Acarbose is an alpha-glucosidase inhibitor prescription medicine that slows carbohydrate digestion. It increases median lifespan in mice around ~20% in males and smaller (~4–5%) in females New paper suggests its effects may not be by controlling sugar but by raising NAD! 🧵

Update: The first human partial reprogramming trial (OSK for glaucoma/NAION) has completed enrollment. Safety data expected Q4 2026. This is the first time epigenetic age reversal has been attempted in humans. We're tracking it →

Ancient cultures were extremely violent, not “peace-loving ecologists” at all!

First drug ever shown to lengthen telomeres in a randomized trial. Henagliflozin, a diabetes drug, for 26 weeks. Results: - Treatment group: 90.5% had longer telomeres - Placebo group: 65.6% - Difference: statistically significant, p<0.01 This isn't a supplement study with 12 people. It's a randomized placebo-controlled trial of a drug millions already take for blood sugar. Telomere shortening is one of the 12 hallmarks of aging. Every decade, your telomeres lose about 14% of their length. This is the first time a pill has reversed that trajectory in a controlled experiment. SGLT2 inhibitors already extend life in heart failure patients. Now we might know one reason why.

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