David Sinclair

Glucose spike from oat milk vs whole milk latte👀

Top 10 Most Influential People in Longevity 1. David Sinclair 2. Bryan Johnson 3. Peter Attia 4. Sam Altman 5. George Church 6. Matt Kaeberlein 7. Aubrey de Grey 8. Brian Kennedy 9. Ray Kurzweil 10. Peter Diamandis

A boy born deaf can now hear for the first time — thanks to gene therapy. For the first time in the United States, gene therapy has helped a child born deaf begin to hear. At Children’s Hospital of Philadelphia (CHOP), doctors treated a young boy who had been profoundly deaf since birth due to a mutation in the OTOF gene. In a groundbreaking procedure, they delivered a healthy version of the gene directly into his inner ear using a minimally invasive endoscopic technique. Four months later, the results are remarkable: the child can now detect speech, ambient noise, and everyday sounds like scissors cutting hair — all through the once-silent ear. The gene was inserted into the cochlea, the ear’s sound-processing center, using a viral vector that passed through a tiny opening called the round window. Only the treated ear improved, providing strong evidence that the gene therapy was responsible. While OTOF mutations are rare, this milestone opens the door to future treatments for many types of hereditary hearing loss — over 150 genes are linked to childhood deafness. The CHOP team’s success signals a major shift in how some forms of congenital deafness might be addressed, potentially replacing or complementing hearing aids and cochlear implants with curative therapies. Source: Children’s Hospital of Philadelphia. (2024). Children’s Hospital of Philadelphia Performs First in U.S. Gene Therapy Procedure to Treat Genetic Hearing Loss.

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