ManuelMuellerLab

@stevenschem @Penn_CBIO @PennMedicine Congratulations Adam, i look forward to hearing about your lab's research.

I am excited to announce that in March, I will start my lab in the Department of Cancer Biology (@Penn_CBIO) at the University of Pennsylvania Perelman School of Medicine (@PennMedicine). Stevens.bio

Semisynthesis of Isomerized Histone H4 Reveals Robustness and Vulnerability of Chromatin toward Molecular Aging | Journal of the American Chemical Society @KingsCollegeLon pubs.acs.org/doi/10.1021/ja…

@kclchemistry @KingsNMES Thanks Kenji for the write-up.

The way the body ages could be more resilient than we thought, new research from @lab_mueller suggests🧓 Examining the ‘wear-and-tear’ of aging on chromatin, the molecule that houses the genome, the work could help produce better anti-aging treatments💅 loom.ly/8sC-v5k

Congratulations co-1st authors @_TianzeZhang & Luis Guerra @kclchemistry and great collaboration with Iana @Beatfierz and Jon.

We chemically synthesized old histones containing an isoAspartate residue to measure the impact of aging on chromatin integrity. We found that chromatin is surprisingly tolerant of this particular form of wear-and-tear, although local perturbations were observed.

Thrilled to announce our group's latest paper in @J_A_C_S: Semisynthesis of Isomerized Histone H4 Reveals Robustness and Vulnerability of Chromatin toward Molecular Aging | Journal of the American Chemical Society pubs.acs.org/doi/full/10.10…

Check out this fully funded PhD studentship on peptidomimetics available in the Wilson group. findaphd.com/phds/project/p…

I have an AstraZeneca-funded PhD position available (4 years), based in my lab (School of Chemistry, University of Nottingham); start date Oct 2025! Traceless Chemoenzymatic Peptide Synthesis Application deadline: 6 Jan 2025. Get in touch!!! findaphd.com/phds/project/t…

@Jeannine__Hess Exciting joint PhD project availble with @Jeannine__Hess at the interface of biomedicinal chemistry and chemical biology through @The_MRC DTP. kcl-mrcdtp.com/project/ration…

Exciting opportunity🚨 Joint PhD position with @lab_mueller 👇🏻Application deadline 29th October 24! kcl-mrcdtp.com/project/ration… Retweets much appreciated!

Come and join my group @TheCrick - we have a PhD tinyurl.com/rhtfbdx4 in metal-peptidic cages and high affinity binders, and will advertise a 3 year PDRA in December for a Chemical Biologist with synthetic and cell work experience. Email if interested, retweets appreciated!

@AJWilsonGroup Thanks very much :)

Very elegant work! Kinetic Resolution of Epimeric Proteins Enables Stereoselective Chemical Mutagenesis | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Kinetic Resolution of Epimeric Proteins Enables Stereoselective Chemical Mutagenesis | Journal of the American Chemical Society @kclchemistry @KingsCollegeLon #Kinetic #Resolution #Epimeric #Proteins #Stereoselective #Chemical #Mutagenesis pubs.acs.org/doi/10.1021/ja…

@NShahLab @J_A_C_S Thanks Neel!

Thrilled to highlight our work on chemoenzymatic protein modification, recently published in @J_A_C_S : Kinetic Resolution of Epimeric Proteins Enables Stereoselective Chemical Mutagenesis | Journal of the American Chemical Society (acs.org)

@JbaraM90 @J_A_C_S Thank you!

@lab_mueller @J_A_C_S Cool work! Congratulations

@Beatfierz @J_A_C_S Thanks Beat!

@lab_mueller @J_A_C_S Cool story, congrats to all!

@J_A_C_S Great collaboration with @rli22 and @nott_lab

@J_A_C_S Led by PhD student Guljannat, we introduced a kinetic resolution step to dehydroalanine chemistry. By cleaving the D-amino acid-containing isomer with a D-peptidase, we combine the stereoselectivity of enzymes with the broad scope of chemo-selective Dha functionalisation.

A new scholarship is available to next year's MRes Chemistry students - apply by 31 August. The Mackenzie Family Scholarship established in the memory of Mr F.H. Mackenzie is a prestigious award covering a £22,000 stipend ⚗️ Find out more 🔗⬇️ loom.ly/72FInaE

Excited about engineering powerful biocatalysts? Check out the open PhD position in my group! 👉zhaw.ch/en/jobs/vacant… Please spread the word!🇨🇭🏔️🧪🌿☀️ @NCCR_Catalysis @ZHAW Photo: ZHAW Wädenswil / Frank Brüderli