Nott Lab

In @CellCellPress, I share a major conceptual challenge for biology in the next decade, inspired by Crick’s Central Dogma: understanding information flow in the cell, the smallest indivisible unit of life bit.ly/4hQMmva

AlphaFold allows scientists to start “asking different questions and potentially opening up whole new areas of research”🧠 Prof Rivka Isaacson @rli22 on how the recent Nobel Prize winner changed her field and collaboration between scientists and AI in @FT ft.com/content/9e8d90…

Just a day after receiving his Nobel Prize, #AlphaFold co-founder Dr John Jumper spoke to King’s students about his groundbreaking work using AI to predict protein structure - and how the prize announcement was kept under wraps. ⬇️ kcl.ac.uk/news/new-nobel… @KCLDocStudies

Interested in piRNAs and transposon DNA methylation? Our new collaborative work revels a key mechanism underpinning the precision of piRNA-guided LINE1 methylation. Congratulation to all the authors! nature.com/articles/s4158…

This is a monumental paper from Arvind. Not only did work out in his PhD how the classic model for allostery haemoglobin evolved. Now he designed allosteric proteins entirely from scratch. It think that's an awesome arc. nature.com/articles/s4158…

@KaHochberg Well deserved!

Having never won as much as poster prize in my entire career, this is an unexpected and great honour. Thank you to the incredible scientists working in our group and Marburg that were instrumental for this!

@Craggs_Lab Wonderful news - congratulations!

Excited to share some personal news: Welcome to the world Milo Augustine Craggs. Born 12 June 2024. 7 lbs 15.5 ozs. Mum and baby doing well - some ongoing ‘sunbed’ treatment to drop his bilirubin levels, but otherwise all happy and healthy.

🌟 Join Our Team! 🌟 We're seeking a talented #postdoc to join us @kclchemistry! Come and explore membraneless organelles, molecular conformations, and enzyme activity with us. 3-year post. Deadline extended to June 30. kcl.ac.uk/jobs/089765-po…

Excited to share new work from @GarrettGinell in which we present an approach for predicting intermolecular interaction driven by disordered regions. We focus on how chemical complementarity can contribute to and even dictate intermolecular interactions biorxiv.org/cgi/content/sh…

We're looking for a #postdoc to join our team @kclchemistry. If you're interested in molecular mechanisms and intracellular phase transitions, please get in touch! 3 year post. Ad closes 16 June: kcl.ac.uk/jobs/089765-po…

Announcing AlphaFold 3: our state-of-the-art AI model for predicting the structure and interactions of all life’s molecules. 🧬 Here’s how we built it with @IsomorphicLabs and what it means for biology. 🧵 dpmd.ai/3URDiNo

🎉🥂Welcome to the 2024 @nmesgradschool research awards! Tonight we're celebrating the research of our third year PhD students in Chemistry, Engineering, Informatics, Mathematics and Physics ! Follow along for updates and winners!

25 April marks the anniversary publication discovering the structure of DNA by Crick, Watson, Franklin, Gosling, and Wilkins. Dr Geoffrey Browell, Head of Archives & Research Collections, presents Photograph 51, pivotal in the helical structure of DNA.⬇️ youtube.com/watch?v=F041-7…

The BBS Elspeth Garman Prize for Public Engagement britishbiophysics.org/elspethgarmanp… will be presented to Prof. Rivka Isaacson @rli22 for her sustained excellence in biophysics public engagement over 25 years in the UK and far beyond. Rivka will present a lecture at a future BBS Meeting.

Chromosomes under the microscope [🔬 dr.bio4ever]

Magnetic Isolation and Concentration (MagIC)-cryo-EM is a new method to enable direct structural analysis of targets captured on nanomagnetic beads, which requires only 0.0005 mg/mL of targets in 100 µL crude solution to make 10 cryo-EM grids. I will explain the magic behind it!

🚨Delighted to announce that the London NMR Forum is returning! The new series begins 5-6pm Thursday 25 Jan @TheCrick, with @DFlemmingHansen discussing "NMR and AI". Short talks are invited from any field of magnetic resonance. Free registration: londonnmr.wordpress.com #nmrchat

Do you know our next PhD students? We have two openings starting this summer, one for engineering of biomolecular condensates, and one for de novo design of protein binders (and their applications). Link and details ⬇️

We are hiring! Do you fancy investigating the role of protein disorder in transcriptional regulation? Come see how the ideas we developed translate into the mammalian cell! You can contribute to mature projects and try out new areas. my.corehr.com/pls/uoxrecruit…

Our first paper is out in @CellCellPress! Led by @born2raisecell, we present a programmable reaction-diffusion system that generates synthetic protein waves, oscillations, and patterns for spatiotemporal circuit design and FM data-encoding in human cells. authors.elsevier.com/a/1iN8ZL7PXmeeN