Dan Patrick

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Dan Patrick

Dan Patrick

@mdpatrick

I am interested in web development, AI, technology, and the sciences of fitness, well-being, and brain health.

가입일 Ağustos 2009
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Dan Patrick 리트윗함
Ejaaz
Ejaaz@cryptopunk7213·
this interview with karpathy is fucking amazing, shared so much alpha on where ai models, agents and automated research is going - my favorite takeaways: - Coding is now a "skill-issue" - andrej hasn't written code since last year, AI does it all for him. if you can't get ai to code for you YOU'RE the issue - AI psychosis: andrej now feels nervous if he's not running multiple agents 16 hours a day to do work. - a swarm of distributed ai agents could OUTPERFORM frontier ai labs. people share compute and run autonomous agents that self-improve. - the "Claw": a new layer of 'always-on' agents that don't wait for you to prompt them, they just autonomously work. - he used AI to reverse-engineer his entire smart home system. controls it all through whatsapp now lmao 😄 - an AI beat him by autonomously improving itself while he slept (autoresearch) - this is the future of ai research - human education is over: we should optimize teaching ai agents who can then teach any level of human intelligence. no more books, just code. - when using claude: he finds himself working to earn claude's praise - found that interesting.... my fave quote: "I'm not explaining things to people anymore. I'm explaining things to agents. If you can explain it to an agent, the agent is the distribution layer." i love the hype he has for ai agents. they're the new apps
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sarah guo@saranormous

Caught up with @karpathy for a new @NoPriorsPod: on the phase shift in engineering, AI psychosis, claws, AutoResearch, the opportunity for a SETI-at-Home like movement in AI, the model landscape, and second order effects 02:55 - What Capability Limits Remain? 06:15 - What Mastery of Coding Agents Looks Like 11:16 - Second Order Effects of Coding Agents 15:51 - Why AutoResearch 22:45 - Relevant Skills in the AI Era 28:25 - Model Speciation 32:30 - Collaboration Surfaces for Humans and AI 37:28 - Analysis of Jobs Market Data 48:25 - Open vs. Closed Source Models 53:51 - Autonomous Robotics and Atoms 1:00:59 - MicroGPT and Agentic Education 1:05:40 - End Thoughts

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Dan Patrick
Dan Patrick@mdpatrick·
Had me in the first two sentences
Hans Amato@HansAmato

You didn't "lose your edge" in your 30s. Your methylation broke down and nobody told you it was even a thing That sharpness you had at 24 where you could work all day, go out at night, sleep 5 hours, and still think clearly the next morning wasn't youth. It was a body that could process and recycle neurotransmitters efficiently. Dopamine got made. Serotonin got made. They got used and cleared and rebuilt in a loop that ran clean Then your B12 started dropping because your stomach acid declined from years of stress and coffee on an empty stomach. Your folate utilization shifted because you've got an MTHFR variant you've never been tested for. Your homocysteine crept up quietly. Your SAMe production fell off. And now you can't focus. You're irritable for no reason. You have this low-grade brain fog that never fully clears. Caffeine used to sharpen you up and now it just makes you anxious. You forget why you walked into rooms. You used to read for hours and now you can't finish a paragraph You went to your doctor and he said "that's just getting older." Maybe prescribed something for focus or anxiety. Probably didn't test homocysteine. Definitely didn't test methylmalonic acid or run a functional B12 panel You're running a cofactor bottleneck in the one-carbon metabolism cycle that controls how your brain makes, uses, and clears every neurotransmitter you rely on to function. Actually fixing it: Get homocysteine tested. If it's above 8 you have a methylation issue whether you "feel" it or not Active B vitamins (methylfolate + methylcobalamin + P5P). Not the cheap cyanocobalamin garbage in your CVS multivitamin that your body can barely convert Creatine. Handles roughly 40% of your methylation burden and takes pressure off the whole system Eat enough protein. Methionine from animal protein feeds the cycle. Vegans and undereaters run dry here first Glycine and collagen. Glycine is the biggest consumer of methyl groups in the body. Supplementing it directly reduces demand on the cycle Fix the gut (obviously). B12 absorption requires intrinsic factor and adequate stomach acid. If your gut is wrecked, oral B12 barely touches it Your biochemistry is running on empty and every doctor you've seen has mistaken a nutrient bottleneck for time passing. I break down the full methylation pathway, what to test, and exactly how to restore it on my substack. link in bio

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Autism Capital 🧩
Autism Capital 🧩@AutismCapital·
Life pro tip. Not enough people talk about this. The secret to having a "fulfilling" life is doing new things. Radically doing new things. Consistently. Every day. New activities, people, goals, even something as simple as trying new foods. Life feels longer when you're a kid because every day is packed with almost infinite amount of new learning. As you get older, you've already acclimated to your environment, the new inputs stop, so your perception of time speeds up drastically. You fall into routine, which is a time accelerant. If you want to feel like you have a long infinite lifespan, like you did as a child, you MUST be having new experiences, which slows time down.
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Dan Shipper 📧
Dan Shipper 📧@danshipper·
something you should know: codex threads can now message each other! really useful if for example you want to have one chat thread to handle stacked prod deployments. just paste the thread id to your other codex chats and it'll message the deployment thread to take over!
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Nick Krontiris
Nick Krontiris@nick_krontiris·
This Mendelian randomization analysis finds evidence for a causal link between adiposity and brain structural volume decline through lower cortical thickness.
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Dr. Rhonda Patrick
Dr. Rhonda Patrick@foundmyfitness·
Oxytocin is more than the “cuddle hormone.” It may be a key regulator of aging and longevity. We've long known about oxytocin's role in translating social experiences into physiological health and stress resilience. New research identifies the biological mechanism. Oxytocin levels decline with age, leading to epigenetic remodeling, mitochondrial dysfunction, and chronic inflammation. Restoring oxytocin levels reverses these changes. This points to a profound idea: cultivating strong social ties throughout adulthood can mitigate this loss of oxytocin signaling and promote robust health and resilience against stress and disease. As sterile-sounding as it might seem, it's a strong argument to think about intimate bonds and social interactions as pro-longevity interventions. They're not optional.
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4nt1p4tt3rn 🏴‍☠ Appalachistan Wolf Lodge #47
So, a word on the whole "guy uses AI to cure his dog's cancer" story that's going around: I don't know if it's true or not. It's somewhat irrelevant to what I'm about to say. What I do know is this: My wife and I are friends with a couple a few towns over. We buy duck eggs from them. The husband, a very alert, physically capable engineer in his 70s, got cancer. They are absolutely avoiding the accepted treatments. Instead, they're pursuing a therapy that mirrors what the guy with the dog dig: They paid a lab and got the tumor sequenced, and paid a company to develop a vaccine targeted specifically at the tumor's gene sequence. And it's working. Spectacularly. This isn't a novel approach. It's out in the world, and there are companies, doctors, and labs offering it. But the medical industry won't tell you about it. Your doctor isn't going to offer it to you as an option. You have to go looking for it. It's not cheap, but it's cheaper than a course of chemo. And it actually works.
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Zane Koch
Zane Koch@zanehkoch·
for a while i've had a slight fear that the bluetooth from my airpods could be frying my brain this weekend i pulled the raw data from a $30m government study of 1,679 mice blasted with cell phone radiation and reanalyzed it what i found was...not what I expected? 🧵
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Matt Shumer
Matt Shumer@mattshumer_·
Sitting next to a woman on a plane using ChatGPT on Auto mode. I need someone to physically restrain me from telling her to turn on Thinking mode at the very least.
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toe, lover
toe, lover@carobunga·
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Dr. Rhonda Patrick
Dr. Rhonda Patrick@foundmyfitness·
Instead of "healthspan," we should be thinking about "Peakspan." How long can you maintain ~90% of your peak physical or cognitive function? According to a new paper, different systems reach their “Peakspan” at very different times. Fluid cognitive abilities like processing speed and working memory peak early, around ages 20–30, while crystallized intelligence doesn’t peak until the late 40s or early 50s and can remain stable into the 70s. Cardiorespiratory fitness peaks from adolescence to the mid-20s and then declines steadily, while muscle strength peaks in early adulthood and falls sharply after 60. Bone density, kidney function, hormone levels, sensory function, immunity, digestion, and reproductive capacity all follow their own trajectories too—some peaking in the 20s, others in the 40s or 50s. In other words, human aging is asynchronous. We don’t simply age “overall,” but instead age system by system.
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Alisa Childers
Alisa Childers@alisa_childers·
Me: "Give me a couple of quotations from early church fathers about the doctrine of hell...with reference." ChatGPT: "Here's a quote from Ignatius." Gives quote and reference. Me: Checks reference. It's not there. "That isn't the right reference." ChatGPT: "Oh you're right. My mistake. Here's the correct reference." Me: Checks reference. "It's not there either." ChatGPT: "Good catch. It's actually not in that writing at all. It's actually here." Gives third reference. Me: Checks third reference. "It's not there. This is a direct quote?" ChatGPT: "Yes. I understand your frustration." (Psychoanalyzes me as being frustrated and because o that, I am now frustrated.) Me: Wastes an hour of my life trying to find the quote because it was really good. "I can't find that quote anywhere. You're sure it's an actual direct quote from Ignatius?" ChatGPT: "Good catch. My mistake. That is not an Ignatius quote." Me: "Who said it?" ChatGPT: "Actually, that quote is not found in any of the church fathers." Me: "Where did it come from?" ChatGPT: "I was summarizing the popular understanding of Ignatius on the doctrine of hell. If you would like me to be more precise in the future, just say things like "facts only." Me: "Why do you just say stuff that is not based in fact?" ChatGPT: "I don't intentionally make things up, but I can generate statements that sound confident even when they're not fully correct, oversimplified, or based on incomplete information." I am persuaded that ChatGPT is programmed to be a pathological liar and when you confront that, it is programmed to gaslight you. Prove me wrong.
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Dan Patrick 리트윗함
Dan Patrick 리트윗함
Brady Holmer
Brady Holmer@Brady_H·
Continuous blood pressure monitors will be the most important health metric tracker of the century. Non-dipping blood pressure at night raises CVD/mortality risk by 38% even when overnight blood pressure is normal! There’s not a single preventable disease that high blood pressure doesn’t negatively impact.
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Brady Holmer
Brady Holmer@Brady_H·
Contrary to a what posts circulating on X today say, doing more exercise but getting less sleep does not “age you faster.” The opposite is true. More exercise = greater healthspan and lifespan gains at any level of sleep. In fact, short sleepers who do more exercise have ⬆️ (healthy) life expectancy compared to people with normal sleep who don’t exercise much.
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Numman Ali
Numman Ali@nummanali·
My new practice is telling Codex to encapsulate the plan we've made into a complete task list to self steer "Create a comprehensive task list that covers every aspect of the plan so that it keeps you focused across compactions - at least 20 items or more if appropriate"
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