Real-world study of apalutamide and enzalutamide in metastatic hormone-sensitive #ProstateCancer. @bilenma@EmoryUniversity joins @neerajaiims@huntsmancancer to discuss this analysis which followed FDA guidance for real-world evidence, requiring pre-planned protocols with defined study design, endpoints, and statistical methodology before data analysis. #WatchNow on UroToday > bit.ly/43iLvOp
UC Takeaways from #ASCOGU26
1) KEYNOTE-B15 is a landmark. Periop EV+pembro vs gem/cis in cis-eligible MIBC: EFS HR 0.53, pCR 55.8% vs 32.5%, OS benefit. First regimen to displace cisplatin in curative-intent bladder cancer in ~25 yrs.
What REALLY makes a good oncologist? in @JCO_ASCO
After 10 years and 203 JCO essays, one thing became clear: expertise alone isn’t enough.
Patient-centered care.
Clear, authentic communication.
Emotional intelligence.
And the harder work
Showing up again and again.
Openness
ESMO-ESTRO consensus statements on the safety of combining radiotherapy with EGFR, ALK, or BRAF/MEK inhibitors in @ESMO_Open. Evidence-based consensus statements providing guidance on the safety of combining RT with EGFR, ALK, or BRAF/MEK inhibitors. esmoopen.com/article/S2059-…
IMVIGOR011: ctDNA guided adjuvant atezolizumab in MIBC shows a ctDNA risk adapted approach identified high risk patients who benefit from ICI therapy, sparing persistently ctDNA-ves (at much lower risk) toxicity. Here #GU26 we show ctDNA+ves have dynamic MTM levels (a bit like
Disitimab Vedotin (HER2/MMAE ADC) was tested in HER2-positive (n=73, RR 55%) and HER2-low (n=78, RR 53%) pretreated advanced bladder cancer outside of China. No clear efficacy difference according to HER status(PFS 6 months and OS 17-20 mnths). Only about 20% of UC patients are
FORMULA-509 @EUplatinum 2026
pubmed.ncbi.nlm.nih.gov/41672869/
Can we safely intensify short-course ADT during salvage RT after prostatectomy? @DrPaulNguyen@DrRanaMcKay
345 pts, sRT + 6 mo GnRH agonist
▪️ Bicalutamide
▪️ vs Abiraterone + Prednisone + Apalutamide
🎯 Overall population
▪️ 3-yr PFS: 74.9% vs 68.5%
HR 0.71 (p=0.063)
▪️ 3-yr MFS: 90.6% vs 87.2%
HR 0.57 (p=0.050)
➡️ Did not meet prespecified statistical significance.
🔎 But here is the signal:
In pts with PSA >0.5 ng/mL:
▪️ 3-yr PFS: 67.2% vs 46.8%
HR 0.50 (p=0.030)
▪️ 3-yr MFS: 84.3% vs 66.1%
HR 0.32 (p=0.014)
📌 Absolute MFS benefit: 18.2%
📌 NNT ≈ 5.5
💡 Interpretation:
• Not practice-changing for all
• Potentially relevant for biologically higher-risk salvage
• Raises the key question:
👉 Is 6 months of intensified AR-axis suppression preferable to longer conventional ADT strategies?
Quality of life vs oncologic control, the real tension.
@OncoAlert@APCCC_Lugano@Silke_Gillessen@AOmlin@Prof_Nick_James@BertrandTOMBAL@LoebStacy@urotoday@ecancer@MedicalwatchHQ#ProstateCancer#SalvageRadiotherapy#ADT#ARPI#EurUrol#GUoncology
Última oportunidad para sumarte a #OncoPrecision26 📍 Vigo · 19–20 feb 2026
La #OncologíadePrecisión ya forma parte de la práctica clínica: NGS, IA, nuevas dianas terapéuticas y aplicación real en consulta, de la mano de especialistas de referencia a nivel nacional.
‼️👇 Mañana se cierran INSCRIPCIONES: tacticsmd.net/actividad/viii…@OncoHULA@mlazqui@SOG_Galicia
Leído en @applesfera : “He viajado a Viena sin hablar alemán confiando solo en la traducción de los AirPods: sorprende, pero no es perfecta” applesfera.com/airpods/he-via…
Tissue and peripheral T cell receptor repertoire predicts immunotherapy response and progression-free survival in NSCLC patients
nature.com/articles/s4159…
Me hace mucha ilusión compartir que somos finalistas en #INNOVAH2025 🙌
Con Código Rojo queremos transformar la forma en la que los médicos acceden a conocimiento y formación, usando #IA como aliada
¿Nos echas una mano con un ❤️ y un RT?
@NovartisSpain@SETH__Oficial@sehh_es
Real-world data on avelumab in first-line maintenance therapy for advanced or metastatic urothelial carcinoma: the SOGUG-AVELUMAB RWD study | Clinical and Translational Oncology link.springer.com/article/10.100…