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8f4
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@pliskin1roquois Thank you for reading. Yeah, going through the history makes it really apparent how many wrong turns were taken in the development of the field of biology.
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@032ilysm Great read. It’s ironic that the bleeding edge of biology has mostly been left in the past.
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The original “creatine boosts DHT” study was extremely bad. Like a study they have first year uni students analyze in a research methodology class, because it’s that problematic. Never made sense.
Jack@jack_schroder_
Finally, a study that destroys the "creatine boosts DHT" narrative. 5g of creatine daily for 12 weeks had zero effects on DHT levels. Only 19 participants, but the methodology is much cleaner than the original claim.
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@stag________ And then the Buddhist would proceed to destroy the possibility of knowledge and objective truth, thereby rendering his own position invalid
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The Thomist would say: “since existence is contingent, God is the thing existence is contingent on”
The Buddhist would say: “since existence is contingent, it cannot be called existence”
Paulus@StYvesWannabe
Reading about Buddhism makes it seem like a religion where someone followed Aquinas's proofs of God by the way of efficient causality, potentiality and actuality, possibility and necessity - but instead of arriving at God said, "huh, so nothing exists after all".
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@thaddeusthought Don’t take 5HTP it’s bad for you and is less effective than various other alternatives depending on what your goal is!
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Should I confess to my priest that I had this? 😬
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Walter Kempner’s Rice Diet helped thousands of patients reverse type 2 diabetes and high blood pressure—and lose substantial weight.
The design was simple:
• Extremely low sodium.
• Up to ~92% of calories from carbs (mostly rice, fruit, and fruit juice).
• Added vitamins/minerals (A, D, B1, B2, B3, B5, and sometimes iron).
• Caloric deficit.
Yes: the weight loss still required eating less, but keeping fat and protein low—especially early—was crucial in fixing their metabolic problems.
Carbs do not inherently cause insulin resistance: the inability to oxidize them does.
What gets in the way of cleanly oxidizing carbs?
• Micronutrient shortfalls; hence the vitamins and minerals.
• Elevated FFAs/excessive FAO blunting glucose use; hence the fat restriction.
• Elevated BCAAs; hence the protein restriction.
There are many ways to improve glucose handling that are less extreme, but the same core principles apply.
Note: In light of what we now know about Na:K ratios being more predictive of blood pressure than isolated sodium intake, Kempner’s extreme sodium restriction was likely unnecessary.
It would be interesting to see a modern parallel group trial on extreme high-carb + vitamins/minerals vs. extreme keto + vitamins/minerals in T2D and more. Tay et al. 2015 isn't good enough.
Lo@artofwifehood
Wouldn’t this exacerbate insulin resistance in an already overweight woman? Seems like these carb maxxing plans are really effective for already fit girls who have 5-15lbs to lose, but maybe a disaster for someone with chronic metabolic disregulation? I honestly have no idea…for every woman trying to lose weight there’s 100’s telling her high fat keto, and 100’s telling her low fat high carb 😔😖 Curious to know if you have results from clients using a CGM on this protocol.
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Take this with a grain of salt since it’s just one cell line, but with the focus on GLP-1 agonists now, I needed to say some thing
GLP-1 can stimulate type 3 deiodinase in in an insulinoma cell line, meaning that it can deactivate the active thyroid hormone T3 into T2
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